Taxane-induced peripheral neuropathy and health-related quality of life in postoperative breast cancer patients undergoing adjuvant chemotherapy: N-SAS BC 02, a randomized clinical trial

Kojiro Shimozuma, Yasuo Ohashi, Ayano Takeuchi, Toshihiko Aranishi, Satoshi Morita, Katsumasa Kuroi, Shozo Ohsumi, Haruhiko Makino, Noriyuki Katsumata, Masaru Kuranami, Kimito Suemasu, Toru Watanabe, Frederick H. Hausheer

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Abstract

Purpose To elucidate whether adjuvant taxane monotherapy is a feasible and tolerable for postoperative breast cancer patients, we evaluated the severity of chemotherapy-induced peripheral neuropathy (CIPN) and the relative tolerability of regimens by health-related quality of life (HRQOL) assessment in node- positive breast cancer patients treated with taxane-containing regimens. Methods We evaluated CIPN and HRQOL in the first 300 patients enrolled in a larger (1,060 total) multicenter phase III trial randomized to one of four adjuvant regimens: (1) anthracycline-cyclophosphamide followed by paclitaxel (ACP), (2) AC followed by docetaxel (ACD), (3) paclitaxel alone (PTX), or (4) docetaxel alone (DTX). CIPN was assessed by the Patient Neurotoxicity Questionnaire (PNQ) and the National Cancer Institute Common Toxicity Criteria, and HRQOL by Functional Assessment of Cancer Therapy-General (FACT-G). CIPN and HRQOL scores were compared between ACP and ACD vs. PTX and DTX, and ACP and PTX vs. ACD and DTX. Results PNQ sensory scores were significantly higher in patients treated with taxane monotherapy compared to treatment with AC followed by taxane (P=.003). No significant differences in PNQ sensory scores were observed between the ACP and PTX vs. ACD and DTX regimens (P=.669). Regardless of taxane regimen, PNQ severity scores for CIPN appear to be largely reversible within 1 year of adjuvant treatment. No significant difference in FACT-G scores was observed between any regimens during the study treatments. Conclusions Patient-reported CIPN was significantly more severe with single-agent adjuvant taxane compared to AC followed by taxane treatment; however, the HRQOL findings support that single-agent taxane treatment is tolerable.

Original languageEnglish
Pages (from-to)3355-3364
Number of pages10
JournalSupportive Care in Cancer
Volume20
Issue number12
DOIs
Publication statusPublished - 2012 Dec 1

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Keywords

  • Adjuvant chemotherapy
  • Chemotherapy-induced peripheral neuropathy
  • Health-related quality of life
  • Patient Neurotoxicity Questionnaire

ASJC Scopus subject areas

  • Oncology

Cite this

Shimozuma, K., Ohashi, Y., Takeuchi, A., Aranishi, T., Morita, S., Kuroi, K., Ohsumi, S., Makino, H., Katsumata, N., Kuranami, M., Suemasu, K., Watanabe, T., & Hausheer, F. H. (2012). Taxane-induced peripheral neuropathy and health-related quality of life in postoperative breast cancer patients undergoing adjuvant chemotherapy: N-SAS BC 02, a randomized clinical trial. Supportive Care in Cancer, 20(12), 3355-3364. https://doi.org/10.1007/s00520-012-1492-x