Abstract
Purpose: To describe the ocular surface disorder in patients with keratoconus. Design: A prospective, case-controlled study. Participants: Seventy-five eyes of 38 patients with keratoconus seen at Uludag University School of Medicine, Department of Ophthalmology, from March 2000 through April 2001, and 80 eyes of 40 normal control subjects were studied. Intervention: The subjects underwent routine ophthalmic examinations, corneal sensitivity measurements, Schirmer test, tear film breakup time (BUT), fluorescein and rose bengal staining of the ocular surface, and conjunctival impression cytology. Main Outcome Measures: Patients and control subjects were compared for corneal sensitivity, tear function, ocular surface staining parameters, goblet cell density, and squamous metaplasia grade. The relation of these parameters to the severity of keratoconus progression was also investigated. Results: The mean corneal sensitivity was significantly lower in keratoconus patients compared with control subjects (P < 0.001). The BUT values were also significantly lower in the keratoconus group. Patients with keratoconus had significantly higher fluorescein and rose bengal staining scores (P < 0.001). Corneal sensitivity and tear function changes seemed to get worse with advanced stages of keratoconus. Impression cytology showed goblet cell loss and conjunctival squamous metaplasia, both of which again related to the extent of progression of keratoconus. Conclusions: The ocular surface disease in keratoconus is characterized by disorder of tear quality, squamous metaplasia, and goblet cell loss, all of which seem to relate to the extent of keratoconus progression.
| Original language | English |
|---|---|
| Pages (from-to) | 1110-1118 |
| Number of pages | 9 |
| Journal | Ophthalmology |
| Volume | 110 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2003 Jun 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Tear function and ocular surface changes in keratoconus. / Dogru, Murat; Karakaya, Hatice; Özçetin, Hikmet; Ertürk, Haluk; Yücel, Ali; Özmen, Ahmet; Baykara, Mehmet; Tsubota, Kazuo.
In: Ophthalmology, Vol. 110, No. 6, 01.06.2003, p. 1110-1118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tear function and ocular surface changes in keratoconus
AU - Dogru, Murat
AU - Karakaya, Hatice
AU - Özçetin, Hikmet
AU - Ertürk, Haluk
AU - Yücel, Ali
AU - Özmen, Ahmet
AU - Baykara, Mehmet
AU - Tsubota, Kazuo
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Purpose: To describe the ocular surface disorder in patients with keratoconus. Design: A prospective, case-controlled study. Participants: Seventy-five eyes of 38 patients with keratoconus seen at Uludag University School of Medicine, Department of Ophthalmology, from March 2000 through April 2001, and 80 eyes of 40 normal control subjects were studied. Intervention: The subjects underwent routine ophthalmic examinations, corneal sensitivity measurements, Schirmer test, tear film breakup time (BUT), fluorescein and rose bengal staining of the ocular surface, and conjunctival impression cytology. Main Outcome Measures: Patients and control subjects were compared for corneal sensitivity, tear function, ocular surface staining parameters, goblet cell density, and squamous metaplasia grade. The relation of these parameters to the severity of keratoconus progression was also investigated. Results: The mean corneal sensitivity was significantly lower in keratoconus patients compared with control subjects (P < 0.001). The BUT values were also significantly lower in the keratoconus group. Patients with keratoconus had significantly higher fluorescein and rose bengal staining scores (P < 0.001). Corneal sensitivity and tear function changes seemed to get worse with advanced stages of keratoconus. Impression cytology showed goblet cell loss and conjunctival squamous metaplasia, both of which again related to the extent of progression of keratoconus. Conclusions: The ocular surface disease in keratoconus is characterized by disorder of tear quality, squamous metaplasia, and goblet cell loss, all of which seem to relate to the extent of keratoconus progression.
AB - Purpose: To describe the ocular surface disorder in patients with keratoconus. Design: A prospective, case-controlled study. Participants: Seventy-five eyes of 38 patients with keratoconus seen at Uludag University School of Medicine, Department of Ophthalmology, from March 2000 through April 2001, and 80 eyes of 40 normal control subjects were studied. Intervention: The subjects underwent routine ophthalmic examinations, corneal sensitivity measurements, Schirmer test, tear film breakup time (BUT), fluorescein and rose bengal staining of the ocular surface, and conjunctival impression cytology. Main Outcome Measures: Patients and control subjects were compared for corneal sensitivity, tear function, ocular surface staining parameters, goblet cell density, and squamous metaplasia grade. The relation of these parameters to the severity of keratoconus progression was also investigated. Results: The mean corneal sensitivity was significantly lower in keratoconus patients compared with control subjects (P < 0.001). The BUT values were also significantly lower in the keratoconus group. Patients with keratoconus had significantly higher fluorescein and rose bengal staining scores (P < 0.001). Corneal sensitivity and tear function changes seemed to get worse with advanced stages of keratoconus. Impression cytology showed goblet cell loss and conjunctival squamous metaplasia, both of which again related to the extent of progression of keratoconus. Conclusions: The ocular surface disease in keratoconus is characterized by disorder of tear quality, squamous metaplasia, and goblet cell loss, all of which seem to relate to the extent of keratoconus progression.
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U2 - 10.1016/S0161-6420(03)00261-6
DO - 10.1016/S0161-6420(03)00261-6
M3 - Article
VL - 110
SP - 1110
EP - 1118
JO - Ophthalmology
JF - Ophthalmology
SN - 0161-6420
IS - 6
ER -