Tear function and ocular surface changes in keratoconus

Murat Dogru, Hatice Karakaya, Hikmet Özçetin, Haluk Ertürk, Ali Yücel, Ahmet Özmen, Mehmet Baykara, Kazuo Tsubota

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Purpose: To describe the ocular surface disorder in patients with keratoconus. Design: A prospective, case-controlled study. Participants: Seventy-five eyes of 38 patients with keratoconus seen at Uludag University School of Medicine, Department of Ophthalmology, from March 2000 through April 2001, and 80 eyes of 40 normal control subjects were studied. Intervention: The subjects underwent routine ophthalmic examinations, corneal sensitivity measurements, Schirmer test, tear film breakup time (BUT), fluorescein and rose bengal staining of the ocular surface, and conjunctival impression cytology. Main Outcome Measures: Patients and control subjects were compared for corneal sensitivity, tear function, ocular surface staining parameters, goblet cell density, and squamous metaplasia grade. The relation of these parameters to the severity of keratoconus progression was also investigated. Results: The mean corneal sensitivity was significantly lower in keratoconus patients compared with control subjects (P < 0.001). The BUT values were also significantly lower in the keratoconus group. Patients with keratoconus had significantly higher fluorescein and rose bengal staining scores (P < 0.001). Corneal sensitivity and tear function changes seemed to get worse with advanced stages of keratoconus. Impression cytology showed goblet cell loss and conjunctival squamous metaplasia, both of which again related to the extent of progression of keratoconus. Conclusions: The ocular surface disease in keratoconus is characterized by disorder of tear quality, squamous metaplasia, and goblet cell loss, all of which seem to relate to the extent of keratoconus progression.

Original languageEnglish
Pages (from-to)1110-1118
Number of pages9
JournalOphthalmology
Volume110
Issue number6
DOIs
Publication statusPublished - 2003 Jun 1
Externally publishedYes

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Keratoconus
Tears
Goblet Cells
Metaplasia
Rose Bengal
Staining and Labeling
Fluorescein
Cell Biology
Eye Diseases
Ophthalmology
Cell Count
Epithelial Cells
Medicine
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Dogru, M., Karakaya, H., Özçetin, H., Ertürk, H., Yücel, A., Özmen, A., ... Tsubota, K. (2003). Tear function and ocular surface changes in keratoconus. Ophthalmology, 110(6), 1110-1118. https://doi.org/10.1016/S0161-6420(03)00261-6

Tear function and ocular surface changes in keratoconus. / Dogru, Murat; Karakaya, Hatice; Özçetin, Hikmet; Ertürk, Haluk; Yücel, Ali; Özmen, Ahmet; Baykara, Mehmet; Tsubota, Kazuo.

In: Ophthalmology, Vol. 110, No. 6, 01.06.2003, p. 1110-1118.

Research output: Contribution to journalArticle

Dogru, M, Karakaya, H, Özçetin, H, Ertürk, H, Yücel, A, Özmen, A, Baykara, M & Tsubota, K 2003, 'Tear function and ocular surface changes in keratoconus', Ophthalmology, vol. 110, no. 6, pp. 1110-1118. https://doi.org/10.1016/S0161-6420(03)00261-6
Dogru M, Karakaya H, Özçetin H, Ertürk H, Yücel A, Özmen A et al. Tear function and ocular surface changes in keratoconus. Ophthalmology. 2003 Jun 1;110(6):1110-1118. https://doi.org/10.1016/S0161-6420(03)00261-6
Dogru, Murat ; Karakaya, Hatice ; Özçetin, Hikmet ; Ertürk, Haluk ; Yücel, Ali ; Özmen, Ahmet ; Baykara, Mehmet ; Tsubota, Kazuo. / Tear function and ocular surface changes in keratoconus. In: Ophthalmology. 2003 ; Vol. 110, No. 6. pp. 1110-1118.
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