Technetium-99m complexes with steroid-2-aminooxyethyliminodiacetic acid conjugates

Reiko Yoda; Yoshiharu Karube; Jiro Takata; Yoshiko Nagata; Yoshikazu Matsushima

doi:10.1248/cpb.47.413

Technetium-99m complexes with steroid-2-aminooxyethyliminodiacetic acid conjugates

Reiko Yoda, Yoshiharu Karube, Jiro Takata, Yoshiko Nagata, Yoshikazu Matsushima

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Conjugates of 2-aminooxyethyliminodiacetic acid with estrone, testosterone, epiandrosterone, 17-α-hydroxy-progesterone and progesterone were synthesized and their complexes with Tc-99m were successfully prepared in good yields, which indicated the agent to be promising for metal-labeling of biomolecules and related substances containing one or more carbonyl groups. The biodistribution and scintigraphic studies in mice bearing Ehrlich tumor and mammary tumor showed that the radioactivity accumulated considerably in the tumor tissues, but the tumor images were somewhat obscured.

Original language	English
Pages (from-to)	413-416
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	47
Issue number	3
DOIs	https://doi.org/10.1248/cpb.47.413
Publication status	Published - 1999 Mar

Keywords

2-aminooxyethyliminodiacetic acid
Bifunctional chelating agent Ehrlich tumor
Estrone
Mammary tumor
Technetium-99m

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.47.413

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title = "Technetium-99m complexes with steroid-2-aminooxyethyliminodiacetic acid conjugates",

abstract = "Conjugates of 2-aminooxyethyliminodiacetic acid with estrone, testosterone, epiandrosterone, 17-α-hydroxy-progesterone and progesterone were synthesized and their complexes with Tc-99m were successfully prepared in good yields, which indicated the agent to be promising for metal-labeling of biomolecules and related substances containing one or more carbonyl groups. The biodistribution and scintigraphic studies in mice bearing Ehrlich tumor and mammary tumor showed that the radioactivity accumulated considerably in the tumor tissues, but the tumor images were somewhat obscured.",

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year = "1999",

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T1 - Technetium-99m complexes with steroid-2-aminooxyethyliminodiacetic acid conjugates

AU - Yoda, Reiko

AU - Karube, Yoshiharu

AU - Takata, Jiro

AU - Nagata, Yoshiko

AU - Matsushima, Yoshikazu

PY - 1999/3

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AB - Conjugates of 2-aminooxyethyliminodiacetic acid with estrone, testosterone, epiandrosterone, 17-α-hydroxy-progesterone and progesterone were synthesized and their complexes with Tc-99m were successfully prepared in good yields, which indicated the agent to be promising for metal-labeling of biomolecules and related substances containing one or more carbonyl groups. The biodistribution and scintigraphic studies in mice bearing Ehrlich tumor and mammary tumor showed that the radioactivity accumulated considerably in the tumor tissues, but the tumor images were somewhat obscured.

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KW - Bifunctional chelating agent Ehrlich tumor

KW - Estrone

KW - Mammary tumor

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Technetium-99m complexes with steroid-2-aminooxyethyliminodiacetic acid conjugates

Abstract

Keywords

ASJC Scopus subject areas

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