Technetium-99m complexes with steroid-2-aminooxyethyliminodiacetic acid conjugates

Reiko Yoda, Yoshiharu Karube, Jiro Takata, Yoshiko Nagata, Yoshikazu Matsushima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Conjugates of 2-aminooxyethyliminodiacetic acid with estrone, testosterone, epiandrosterone, 17-α-hydroxy-progesterone and progesterone were synthesized and their complexes with Tc-99m were successfully prepared in good yields, which indicated the agent to be promising for metal-labeling of biomolecules and related substances containing one or more carbonyl groups. The biodistribution and scintigraphic studies in mice bearing Ehrlich tumor and mammary tumor showed that the radioactivity accumulated considerably in the tumor tissues, but the tumor images were somewhat obscured.

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume47
Issue number3
DOIs
Publication statusPublished - 1999 Mar

Keywords

  • 2-aminooxyethyliminodiacetic acid
  • Bifunctional chelating agent Ehrlich tumor
  • Estrone
  • Mammary tumor
  • Technetium-99m

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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