Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Taisuke Kinoshita, Go Nagamatsu, Shigeru Saito, Keiyo Takubo, Katsuhisa Horimoto, Toshio Suda

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: The contribution of TERT to cellular reprogramming is unclear. Results: KO of TERT reduces the reprogramming efficiency of somatic cells, and continuous growth induces chromosome abnormalities; enzymatically inactive TERT rescues the efficiency. Conclusion: TERT has a telomerase-independent role in somatic cell reprogramming. Significance: Understanding the cellular reprogramming process is crucial for the clinical applications of induced pluripotent stem cells.

Original languageEnglish
Pages (from-to)15776-15787
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
Publication statusPublished - 2014 May 30

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Telomerase
Chromosomes
Stem cells
Induced Pluripotent Stem Cells
Chromosome Aberrations
Growth
Cellular Reprogramming

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Kinoshita, T., Nagamatsu, G., Saito, S., Takubo, K., Horimoto, K., & Suda, T. (2014). Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming. Journal of Biological Chemistry, 289(22), 15776-15787. https://doi.org/10.1074/jbc.M113.536037

Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming. / Kinoshita, Taisuke; Nagamatsu, Go; Saito, Shigeru; Takubo, Keiyo; Horimoto, Katsuhisa; Suda, Toshio.

In: Journal of Biological Chemistry, Vol. 289, No. 22, 30.05.2014, p. 15776-15787.

Research output: Contribution to journalArticle

Kinoshita, T, Nagamatsu, G, Saito, S, Takubo, K, Horimoto, K & Suda, T 2014, 'Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming', Journal of Biological Chemistry, vol. 289, no. 22, pp. 15776-15787. https://doi.org/10.1074/jbc.M113.536037
Kinoshita, Taisuke ; Nagamatsu, Go ; Saito, Shigeru ; Takubo, Keiyo ; Horimoto, Katsuhisa ; Suda, Toshio. / Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 22. pp. 15776-15787.
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