Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Taisuke Kinoshita; Go Nagamatsu; Shigeru Saito; Keiyo Takubo; Katsuhisa Horimoto; Toshio Suda

doi:10.1074/jbc.M113.536037

Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Taisuke Kinoshita, Go Nagamatsu, Shigeru Saito, Keiyo Takubo, Katsuhisa Horimoto, Toshio Suda

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Background: The contribution of TERT to cellular reprogramming is unclear. Results: KO of TERT reduces the reprogramming efficiency of somatic cells, and continuous growth induces chromosome abnormalities; enzymatically inactive TERT rescues the efficiency. Conclusion: TERT has a telomerase-independent role in somatic cell reprogramming. Significance: Understanding the cellular reprogramming process is crucial for the clinical applications of induced pluripotent stem cells.

Original language	English
Pages (from-to)	15776-15787
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M113.536037
Publication status	Published - 2014 May 30
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: The contribution of TERT to cellular reprogramming is unclear. Results: KO of TERT reduces the reprogramming efficiency of somatic cells, and continuous growth induces chromosome abnormalities; enzymatically inactive TERT rescues the efficiency. Conclusion: TERT has a telomerase-independent role in somatic cell reprogramming. Significance: Understanding the cellular reprogramming process is crucial for the clinical applications of induced pluripotent stem cells.",

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AU - Kinoshita, Taisuke

AU - Nagamatsu, Go

AU - Saito, Shigeru

AU - Takubo, Keiyo

AU - Horimoto, Katsuhisa

AU - Suda, Toshio

PY - 2014/5/30

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N2 - Background: The contribution of TERT to cellular reprogramming is unclear. Results: KO of TERT reduces the reprogramming efficiency of somatic cells, and continuous growth induces chromosome abnormalities; enzymatically inactive TERT rescues the efficiency. Conclusion: TERT has a telomerase-independent role in somatic cell reprogramming. Significance: Understanding the cellular reprogramming process is crucial for the clinical applications of induced pluripotent stem cells.

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Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Abstract

ASJC Scopus subject areas

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