Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Taisuke Kinoshita, Go Nagamatsu, Shigeru Saito, Keiyo Takubo, Katsuhisa Horimoto, Toshio Suda

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: The contribution of TERT to cellular reprogramming is unclear. Results: KO of TERT reduces the reprogramming efficiency of somatic cells, and continuous growth induces chromosome abnormalities; enzymatically inactive TERT rescues the efficiency. Conclusion: TERT has a telomerase-independent role in somatic cell reprogramming. Significance: Understanding the cellular reprogramming process is crucial for the clinical applications of induced pluripotent stem cells.

Original languageEnglish
Pages (from-to)15776-15787
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
Publication statusPublished - 2014 May 30

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Kinoshita, T., Nagamatsu, G., Saito, S., Takubo, K., Horimoto, K., & Suda, T. (2014). Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming. Journal of Biological Chemistry, 289(22), 15776-15787. https://doi.org/10.1074/jbc.M113.536037