Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT

Yumiko Matsubara, Mitsuru Murata, Tadashi Yoshida, Kiyoaki Watanabe, Ikuo Saito, Koichi Miyaki, Kazuyuki Omae, Yasuo Ikeda

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Transcriptional regulation of human telomerase reverse transcriptase (hTERT), a catalytic subunit of telomerase, is essential for telomerase activity associated with telomere length. In this study, we investigated the effects of a -1327T/C polymorphism within the hTERT promoter region on the hTERT promoter activity and leukocyte telomere length in normal individuals. The promoter activity in the -1327T-sequence was significantly higher than that in the -1327C-sequence (p = 0.0004). For leukocyte telomere length, the -1327T-allele carriers had significantly longer than the -1327T-allele non-carriers (p = 0.0007). Also, there was no age-related shortening in leukocyte telomere length in the -1327T/T (p = 0.6633) and -1327T/C subjects (p = 0.1691), whereas there was clear age-related telomere shortening in the -1327C/C subjects (p = 0.0117). These findings suggest that the functional -1327T/C polymorphism of hTERT is associated with leukocyte telomere length in normal individuals.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume341
Issue number1
DOIs
Publication statusPublished - 2006 Mar 3

Keywords

  • Human telomerase reverse transcriptase
  • Polymorphism
  • Telomere length

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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