Temperature-responsive chromatography

Y. Matsushma, H. Kanazawa, T. Okano

Research output: Contribution to journalShort surveypeer-review


We have developed a new method for HPLC which uses packing materials modified with a temperature-responsive polymer, poly(N-isopropylacrylamide). The surface properties and functions of the stationary phases are controlled by the external temperature. In the proposed chromatographic system, the elution of target substances is controlled by only a small change in the column temperatures. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)435-440
Number of pages6
JournalEuropean journal of pharmacology
Issue number2-3
Publication statusPublished - 1999
Externally publishedYes


  • Poly(N-isopropylacrylamide)
  • Stationary phases, thermosensitive
  • Temperature-responsive chromatography

ASJC Scopus subject areas

  • Pharmacology


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