Temperature-responsive polymers for liquid-phase separations

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The use of temperature-responsive polymers for liquid-phase separations is analyzed. Poly N-isopropyl acrylamide (PNIPAAm) has the sharpest phase transition of class of thermosensitive N-alkylacrylamide polymers. PNIPAAm copolymers containing anionic acrylic acid (AAc) or cationic dimethylaminopropylacrylamide (DMAPPAm) produce alterable properties of the stationary phase with both thermally regulated hydrophobicity and charge density for separation of bioactive compounds. Furthermore, the temperature-responsive chromatography system utilizing PNIPAAm derivatives would be highly useful for peptide and protein separation, since chromatographic separation is performed under mild acqueous mobile phase conditions.

Original languageEnglish
Pages (from-to)46-48
Number of pages3
JournalAnalytical and Bioanalytical Chemistry
Volume378
Issue number1
DOIs
Publication statusPublished - 2004 Jan

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Phase separation
Polymers
Temperature
Liquids
Phase Transition
Hydrophobicity
Chromatography
Charge density
Hydrophobic and Hydrophilic Interactions
Copolymers
Phase transitions
Derivatives
Peptides
poly-N-isopropylacrylamide
Proteins
acrylic acid

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

Temperature-responsive polymers for liquid-phase separations. / Kanazawa, Hideko.

In: Analytical and Bioanalytical Chemistry, Vol. 378, No. 1, 01.2004, p. 46-48.

Research output: Contribution to journalArticle

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