Ten-year incidences of self-reported non-vertebral fractures in Japanese patients with rheumatoid arthritis: discrepancy between disease activity control and the incidence of non-vertebral fracture

K. Ochi, E. Inoue, T. Furuya, K. Ikari, Y. Toyama, A. Taniguchi, H. Yamanaka, S. Momohara

Research output: Contribution to journalArticle

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Abstract

Introduction: Although rheumatoid arthritis (RA) is a risk factor for osteoporosis and fractures, few studies have described the association between disease activity and the fracture incidence in patients with RA. This study aimed to investigate changes in the non-vertebral fracture incidence between 2001 and 2010 in our Institute of Rheumatology Rheumatoid Arthritis (IORRA) cohort.

Summary: Despite improvements in rheumatoid arthritis disease activity of in the past 10 years, the incidence of self-reported non-vertebral fractures did not decrease in our cohort of 9,987 patients. This study may indicate that osteoporosis treatment and non-vertebral fracture prevention remain important regardless of the rheumatoid arthritis disease activity.

Methods: The IORRA is a prospective observational cohort study of Japanese RA patients. A total of 9,987 patients with RA were enrolled in this cohort from 2000 to 2010. The clinical parameter and non-vertebral fracture occurrence data were collected biannually through self-reported questionnaires. Incidences of self-reported non-vertebral fractures were also analyzed via standardization according to gender, age, and disease activity during each 2-year period.

Results: From 2001 to 2010, the percentage of patients with 28-joint disease activity score remission increased from 7.8 to 39.7 %, prednisolone intake decreased from 51.4 to 41.3 %, and bisphosphonate intake increased from 5.0 to 23.4 %. The non-vertebral fracture incidence rates were 24.6/1,000 person-years in 2001 and 35.5/1,000 person-years in 2010, with no apparent change even after standardization. The overall non-vertebral fracture incidence was significantly higher in the autumn/winter than in the spring/summer (p = 0.02).

Conclusion: Despite improvements in disease activity and functional disability, the non-vertebral fracture incidence exhibited no apparent change between 2001 and 2010 in our patients with RA. Osteoporosis treatment and non-vertebral fracture prevention remain important regardless of the disease control in patients with RA.

Original languageEnglish
Pages (from-to)961-968
Number of pages8
JournalOsteoporosis International
Volume26
Issue number3
DOIs
Publication statusPublished - 2015

Fingerprint

Rheumatoid Arthritis
Incidence
Osteoporosis
Rheumatology
Joint Diseases
Diphosphonates
Prednisolone
Observational Studies
Cohort Studies
Therapeutics

Keywords

  • Disease activity
  • Functional impairment
  • Incidence
  • Non-vertebral fracture
  • Osteoporosis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Ten-year incidences of self-reported non-vertebral fractures in Japanese patients with rheumatoid arthritis : discrepancy between disease activity control and the incidence of non-vertebral fracture. / Ochi, K.; Inoue, E.; Furuya, T.; Ikari, K.; Toyama, Y.; Taniguchi, A.; Yamanaka, H.; Momohara, S.

In: Osteoporosis International, Vol. 26, No. 3, 2015, p. 961-968.

Research output: Contribution to journalArticle

Ochi, K. ; Inoue, E. ; Furuya, T. ; Ikari, K. ; Toyama, Y. ; Taniguchi, A. ; Yamanaka, H. ; Momohara, S. / Ten-year incidences of self-reported non-vertebral fractures in Japanese patients with rheumatoid arthritis : discrepancy between disease activity control and the incidence of non-vertebral fracture. In: Osteoporosis International. 2015 ; Vol. 26, No. 3. pp. 961-968.
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T1 - Ten-year incidences of self-reported non-vertebral fractures in Japanese patients with rheumatoid arthritis

T2 - discrepancy between disease activity control and the incidence of non-vertebral fracture

AU - Ochi, K.

AU - Inoue, E.

AU - Furuya, T.

AU - Ikari, K.

AU - Toyama, Y.

AU - Taniguchi, A.

AU - Yamanaka, H.

AU - Momohara, S.

PY - 2015

Y1 - 2015

N2 - Introduction: Although rheumatoid arthritis (RA) is a risk factor for osteoporosis and fractures, few studies have described the association between disease activity and the fracture incidence in patients with RA. This study aimed to investigate changes in the non-vertebral fracture incidence between 2001 and 2010 in our Institute of Rheumatology Rheumatoid Arthritis (IORRA) cohort.Summary: Despite improvements in rheumatoid arthritis disease activity of in the past 10 years, the incidence of self-reported non-vertebral fractures did not decrease in our cohort of 9,987 patients. This study may indicate that osteoporosis treatment and non-vertebral fracture prevention remain important regardless of the rheumatoid arthritis disease activity.Methods: The IORRA is a prospective observational cohort study of Japanese RA patients. A total of 9,987 patients with RA were enrolled in this cohort from 2000 to 2010. The clinical parameter and non-vertebral fracture occurrence data were collected biannually through self-reported questionnaires. Incidences of self-reported non-vertebral fractures were also analyzed via standardization according to gender, age, and disease activity during each 2-year period.Results: From 2001 to 2010, the percentage of patients with 28-joint disease activity score remission increased from 7.8 to 39.7 %, prednisolone intake decreased from 51.4 to 41.3 %, and bisphosphonate intake increased from 5.0 to 23.4 %. The non-vertebral fracture incidence rates were 24.6/1,000 person-years in 2001 and 35.5/1,000 person-years in 2010, with no apparent change even after standardization. The overall non-vertebral fracture incidence was significantly higher in the autumn/winter than in the spring/summer (p = 0.02).Conclusion: Despite improvements in disease activity and functional disability, the non-vertebral fracture incidence exhibited no apparent change between 2001 and 2010 in our patients with RA. Osteoporosis treatment and non-vertebral fracture prevention remain important regardless of the disease control in patients with RA.

AB - Introduction: Although rheumatoid arthritis (RA) is a risk factor for osteoporosis and fractures, few studies have described the association between disease activity and the fracture incidence in patients with RA. This study aimed to investigate changes in the non-vertebral fracture incidence between 2001 and 2010 in our Institute of Rheumatology Rheumatoid Arthritis (IORRA) cohort.Summary: Despite improvements in rheumatoid arthritis disease activity of in the past 10 years, the incidence of self-reported non-vertebral fractures did not decrease in our cohort of 9,987 patients. This study may indicate that osteoporosis treatment and non-vertebral fracture prevention remain important regardless of the rheumatoid arthritis disease activity.Methods: The IORRA is a prospective observational cohort study of Japanese RA patients. A total of 9,987 patients with RA were enrolled in this cohort from 2000 to 2010. The clinical parameter and non-vertebral fracture occurrence data were collected biannually through self-reported questionnaires. Incidences of self-reported non-vertebral fractures were also analyzed via standardization according to gender, age, and disease activity during each 2-year period.Results: From 2001 to 2010, the percentage of patients with 28-joint disease activity score remission increased from 7.8 to 39.7 %, prednisolone intake decreased from 51.4 to 41.3 %, and bisphosphonate intake increased from 5.0 to 23.4 %. The non-vertebral fracture incidence rates were 24.6/1,000 person-years in 2001 and 35.5/1,000 person-years in 2010, with no apparent change even after standardization. The overall non-vertebral fracture incidence was significantly higher in the autumn/winter than in the spring/summer (p = 0.02).Conclusion: Despite improvements in disease activity and functional disability, the non-vertebral fracture incidence exhibited no apparent change between 2001 and 2010 in our patients with RA. Osteoporosis treatment and non-vertebral fracture prevention remain important regardless of the disease control in patients with RA.

KW - Disease activity

KW - Functional impairment

KW - Incidence

KW - Non-vertebral fracture

KW - Osteoporosis

KW - Rheumatoid arthritis

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