TY - JOUR
T1 - Ten-year incidences of self-reported non-vertebral fractures in Japanese patients with rheumatoid arthritis
T2 - discrepancy between disease activity control and the incidence of non-vertebral fracture
AU - Ochi, K.
AU - Inoue, E.
AU - Furuya, T.
AU - Ikari, K.
AU - Toyama, Y.
AU - Taniguchi, A.
AU - Yamanaka, H.
AU - Momohara, S.
N1 - Funding Information:
This work was supported in part by grants-in-aid for scientific research from the Japan Society for the Promotion of Science, the Nakatomi Foundation, the Japan Orthopedics and Traumatology Foundation, Inc. No. 277, and the Japan Osteoporosis Foundation to KO as well as from the Japan Osteoporosis Society to TF.
Publisher Copyright:
© 2014, International Osteoporosis Foundation and National Osteoporosis Foundation.
PY - 2015/2/18
Y1 - 2015/2/18
N2 - Introduction: Although rheumatoid arthritis (RA) is a risk factor for osteoporosis and fractures, few studies have described the association between disease activity and the fracture incidence in patients with RA. This study aimed to investigate changes in the non-vertebral fracture incidence between 2001 and 2010 in our Institute of Rheumatology Rheumatoid Arthritis (IORRA) cohort.Summary: Despite improvements in rheumatoid arthritis disease activity of in the past 10 years, the incidence of self-reported non-vertebral fractures did not decrease in our cohort of 9,987 patients. This study may indicate that osteoporosis treatment and non-vertebral fracture prevention remain important regardless of the rheumatoid arthritis disease activity.Methods: The IORRA is a prospective observational cohort study of Japanese RA patients. A total of 9,987 patients with RA were enrolled in this cohort from 2000 to 2010. The clinical parameter and non-vertebral fracture occurrence data were collected biannually through self-reported questionnaires. Incidences of self-reported non-vertebral fractures were also analyzed via standardization according to gender, age, and disease activity during each 2-year period.Results: From 2001 to 2010, the percentage of patients with 28-joint disease activity score remission increased from 7.8 to 39.7 %, prednisolone intake decreased from 51.4 to 41.3 %, and bisphosphonate intake increased from 5.0 to 23.4 %. The non-vertebral fracture incidence rates were 24.6/1,000 person-years in 2001 and 35.5/1,000 person-years in 2010, with no apparent change even after standardization. The overall non-vertebral fracture incidence was significantly higher in the autumn/winter than in the spring/summer (p = 0.02).Conclusion: Despite improvements in disease activity and functional disability, the non-vertebral fracture incidence exhibited no apparent change between 2001 and 2010 in our patients with RA. Osteoporosis treatment and non-vertebral fracture prevention remain important regardless of the disease control in patients with RA.
AB - Introduction: Although rheumatoid arthritis (RA) is a risk factor for osteoporosis and fractures, few studies have described the association between disease activity and the fracture incidence in patients with RA. This study aimed to investigate changes in the non-vertebral fracture incidence between 2001 and 2010 in our Institute of Rheumatology Rheumatoid Arthritis (IORRA) cohort.Summary: Despite improvements in rheumatoid arthritis disease activity of in the past 10 years, the incidence of self-reported non-vertebral fractures did not decrease in our cohort of 9,987 patients. This study may indicate that osteoporosis treatment and non-vertebral fracture prevention remain important regardless of the rheumatoid arthritis disease activity.Methods: The IORRA is a prospective observational cohort study of Japanese RA patients. A total of 9,987 patients with RA were enrolled in this cohort from 2000 to 2010. The clinical parameter and non-vertebral fracture occurrence data were collected biannually through self-reported questionnaires. Incidences of self-reported non-vertebral fractures were also analyzed via standardization according to gender, age, and disease activity during each 2-year period.Results: From 2001 to 2010, the percentage of patients with 28-joint disease activity score remission increased from 7.8 to 39.7 %, prednisolone intake decreased from 51.4 to 41.3 %, and bisphosphonate intake increased from 5.0 to 23.4 %. The non-vertebral fracture incidence rates were 24.6/1,000 person-years in 2001 and 35.5/1,000 person-years in 2010, with no apparent change even after standardization. The overall non-vertebral fracture incidence was significantly higher in the autumn/winter than in the spring/summer (p = 0.02).Conclusion: Despite improvements in disease activity and functional disability, the non-vertebral fracture incidence exhibited no apparent change between 2001 and 2010 in our patients with RA. Osteoporosis treatment and non-vertebral fracture prevention remain important regardless of the disease control in patients with RA.
KW - Disease activity
KW - Functional impairment
KW - Incidence
KW - Non-vertebral fracture
KW - Osteoporosis
KW - Rheumatoid arthritis
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U2 - 10.1007/s00198-014-2911-2
DO - 10.1007/s00198-014-2911-2
M3 - Article
C2 - 25294026
AN - SCOPUS:84925503593
SN - 0937-941X
VL - 26
SP - 961
EP - 968
JO - Osteoporosis International
JF - Osteoporosis International
IS - 3
ER -
