Tensile load and the metabolism of anterior cruciate ligament cells

Takashi Toyoda, Hideo Matsumoto, Kyosuke Fujikawa, Seiji Saito, Kazuhiko Inoue

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

It generally is recognized that tensile load plays a major role in maintaining the homeostasis of the anterior cruciate ligament fibers, but its detailed mechanism remains a matter of controversy. The effects of cyclic tensile load on the metabolism of the anterior cruciate ligament were investigated experimentally using cultured cells from the anterior cruciate ligament of rabbits. Using culture plates with flexible rubber bases, a cyclic tensile load was applied to the cultured cells for 24 hours, and the changes in shape, alignment, and metabolism of the cells were analyzed. Under the cyclic tensile load, the shape of the cells from the anterior cruciate ligament changed to spindle and aligned perpendicularly to the direction of the tensile load. The cyclic tensile load also caused an increase in collagen synthesis by the cells from the anterior cruciate ligament, which was predominant in Type I. The cells from the synovium showed similar changes in shape and alignment under the cyclic tensile load, but no significant change was observed in cell metabolism. These observations suggest that the application of cyclic tensile load on the anterior cruciate ligament cells is an important factor in the regulation of collagen synthesis in the anterior cruciate ligament.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalClinical Orthopaedics and Related Research
Issue number353
Publication statusPublished - 1998

Fingerprint

Anterior Cruciate Ligament
Cultured Cells
Collagen
Cell Shape
Synovial Membrane
Rubber
Homeostasis
Rabbits

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Toyoda, T., Matsumoto, H., Fujikawa, K., Saito, S., & Inoue, K. (1998). Tensile load and the metabolism of anterior cruciate ligament cells. Clinical Orthopaedics and Related Research, (353), 247-255.

Tensile load and the metabolism of anterior cruciate ligament cells. / Toyoda, Takashi; Matsumoto, Hideo; Fujikawa, Kyosuke; Saito, Seiji; Inoue, Kazuhiko.

In: Clinical Orthopaedics and Related Research, No. 353, 1998, p. 247-255.

Research output: Contribution to journalArticle

Toyoda, T, Matsumoto, H, Fujikawa, K, Saito, S & Inoue, K 1998, 'Tensile load and the metabolism of anterior cruciate ligament cells', Clinical Orthopaedics and Related Research, no. 353, pp. 247-255.
Toyoda T, Matsumoto H, Fujikawa K, Saito S, Inoue K. Tensile load and the metabolism of anterior cruciate ligament cells. Clinical Orthopaedics and Related Research. 1998;(353):247-255.
Toyoda, Takashi ; Matsumoto, Hideo ; Fujikawa, Kyosuke ; Saito, Seiji ; Inoue, Kazuhiko. / Tensile load and the metabolism of anterior cruciate ligament cells. In: Clinical Orthopaedics and Related Research. 1998 ; No. 353. pp. 247-255.
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