Tentative diagnostic criteria and disease severity classification for Castleman disease: A report of the research group on Castleman disease in Japan

Shino Fujimoto, Tomohiro Koga, Atsushi Kawakami, Hiroshi Kawabata, Shinichiro Okamoto, Masao Mizuki, Shingo Yano, Makoto Ide, Kazuko Uno, Katsumi Yagi, Toshiyuki Kojima, Minoru Mizutani, Yukihiro Tokumine, Norihiro Nishimoto, Hiroshi Fujiwara, Shin ichi Nakatsuka, Kazuko Shiozawa, Noriko Iwaki, Yasufumi Masaki, Kazuyuki Yoshizaki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: To determine the tentative diagnostic criteria and disease severity classification for Castleman disease (CD) and describe the clinical and pathologic features among human herpesvirus 8 (HHV-8) negative idiopathic multicentric CD (iMCD) in the Japanese population. Methods: We established the working groups for the research of CD in Japan and had meetings to discuss and define the tentative diagnostic criteria and disease severity classification for CD. We subsequently analyzed 142 patients classified into iMCD by using the nationwide Japanese patient registry. Results: We proposed the preliminary diagnostic criteria and disease severity classification for CD based on our discussion. In addition, we made a proposal for the disease activity score. We identified clinical and pathological features of patients with iMCD diagnosed by these diagnostic criteria. In the disease severity classification, 37, 33 and 30% patients were categorized into mild, moderate and severe diseases, respectively. Conclusion: This is the first proposal for diagnosis and classification of CD by the Japanese group. Further studies are required to validate whether they can distinguish CD from other inflammatory diseases and to determine their sensitivity and specificity.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalModern Rheumatology
Volume28
Issue number1
DOIs
Publication statusPublished - 2018 Jan 2

Fingerprint

Giant Lymph Node Hyperplasia
Japan
Research
Human Herpesvirus 8
Registries
Sensitivity and Specificity

Keywords

  • Castleman disease
  • diagnostic criteria
  • disease severity classification
  • idiopathic multicentric Castleman disease
  • TAFRO syndrome

ASJC Scopus subject areas

  • Rheumatology

Cite this

Tentative diagnostic criteria and disease severity classification for Castleman disease : A report of the research group on Castleman disease in Japan. / Fujimoto, Shino; Koga, Tomohiro; Kawakami, Atsushi; Kawabata, Hiroshi; Okamoto, Shinichiro; Mizuki, Masao; Yano, Shingo; Ide, Makoto; Uno, Kazuko; Yagi, Katsumi; Kojima, Toshiyuki; Mizutani, Minoru; Tokumine, Yukihiro; Nishimoto, Norihiro; Fujiwara, Hiroshi; Nakatsuka, Shin ichi; Shiozawa, Kazuko; Iwaki, Noriko; Masaki, Yasufumi; Yoshizaki, Kazuyuki.

In: Modern Rheumatology, Vol. 28, No. 1, 02.01.2018, p. 161-167.

Research output: Contribution to journalArticle

Fujimoto, S, Koga, T, Kawakami, A, Kawabata, H, Okamoto, S, Mizuki, M, Yano, S, Ide, M, Uno, K, Yagi, K, Kojima, T, Mizutani, M, Tokumine, Y, Nishimoto, N, Fujiwara, H, Nakatsuka, SI, Shiozawa, K, Iwaki, N, Masaki, Y & Yoshizaki, K 2018, 'Tentative diagnostic criteria and disease severity classification for Castleman disease: A report of the research group on Castleman disease in Japan', Modern Rheumatology, vol. 28, no. 1, pp. 161-167. https://doi.org/10.1080/14397595.2017.1366093
Fujimoto, Shino ; Koga, Tomohiro ; Kawakami, Atsushi ; Kawabata, Hiroshi ; Okamoto, Shinichiro ; Mizuki, Masao ; Yano, Shingo ; Ide, Makoto ; Uno, Kazuko ; Yagi, Katsumi ; Kojima, Toshiyuki ; Mizutani, Minoru ; Tokumine, Yukihiro ; Nishimoto, Norihiro ; Fujiwara, Hiroshi ; Nakatsuka, Shin ichi ; Shiozawa, Kazuko ; Iwaki, Noriko ; Masaki, Yasufumi ; Yoshizaki, Kazuyuki. / Tentative diagnostic criteria and disease severity classification for Castleman disease : A report of the research group on Castleman disease in Japan. In: Modern Rheumatology. 2018 ; Vol. 28, No. 1. pp. 161-167.
@article{7b48bbc488794baaa87b202cb96e681d,
title = "Tentative diagnostic criteria and disease severity classification for Castleman disease: A report of the research group on Castleman disease in Japan",
abstract = "Objectives: To determine the tentative diagnostic criteria and disease severity classification for Castleman disease (CD) and describe the clinical and pathologic features among human herpesvirus 8 (HHV-8) negative idiopathic multicentric CD (iMCD) in the Japanese population. Methods: We established the working groups for the research of CD in Japan and had meetings to discuss and define the tentative diagnostic criteria and disease severity classification for CD. We subsequently analyzed 142 patients classified into iMCD by using the nationwide Japanese patient registry. Results: We proposed the preliminary diagnostic criteria and disease severity classification for CD based on our discussion. In addition, we made a proposal for the disease activity score. We identified clinical and pathological features of patients with iMCD diagnosed by these diagnostic criteria. In the disease severity classification, 37, 33 and 30{\%} patients were categorized into mild, moderate and severe diseases, respectively. Conclusion: This is the first proposal for diagnosis and classification of CD by the Japanese group. Further studies are required to validate whether they can distinguish CD from other inflammatory diseases and to determine their sensitivity and specificity.",
keywords = "Castleman disease, diagnostic criteria, disease severity classification, idiopathic multicentric Castleman disease, TAFRO syndrome",
author = "Shino Fujimoto and Tomohiro Koga and Atsushi Kawakami and Hiroshi Kawabata and Shinichiro Okamoto and Masao Mizuki and Shingo Yano and Makoto Ide and Kazuko Uno and Katsumi Yagi and Toshiyuki Kojima and Minoru Mizutani and Yukihiro Tokumine and Norihiro Nishimoto and Hiroshi Fujiwara and Nakatsuka, {Shin ichi} and Kazuko Shiozawa and Noriko Iwaki and Yasufumi Masaki and Kazuyuki Yoshizaki",
year = "2018",
month = "1",
day = "2",
doi = "10.1080/14397595.2017.1366093",
language = "English",
volume = "28",
pages = "161--167",
journal = "Modern Rheumatology",
issn = "1439-7595",
publisher = "Springer Japan",
number = "1",

}

TY - JOUR

T1 - Tentative diagnostic criteria and disease severity classification for Castleman disease

T2 - A report of the research group on Castleman disease in Japan

AU - Fujimoto, Shino

AU - Koga, Tomohiro

AU - Kawakami, Atsushi

AU - Kawabata, Hiroshi

AU - Okamoto, Shinichiro

AU - Mizuki, Masao

AU - Yano, Shingo

AU - Ide, Makoto

AU - Uno, Kazuko

AU - Yagi, Katsumi

AU - Kojima, Toshiyuki

AU - Mizutani, Minoru

AU - Tokumine, Yukihiro

AU - Nishimoto, Norihiro

AU - Fujiwara, Hiroshi

AU - Nakatsuka, Shin ichi

AU - Shiozawa, Kazuko

AU - Iwaki, Noriko

AU - Masaki, Yasufumi

AU - Yoshizaki, Kazuyuki

PY - 2018/1/2

Y1 - 2018/1/2

N2 - Objectives: To determine the tentative diagnostic criteria and disease severity classification for Castleman disease (CD) and describe the clinical and pathologic features among human herpesvirus 8 (HHV-8) negative idiopathic multicentric CD (iMCD) in the Japanese population. Methods: We established the working groups for the research of CD in Japan and had meetings to discuss and define the tentative diagnostic criteria and disease severity classification for CD. We subsequently analyzed 142 patients classified into iMCD by using the nationwide Japanese patient registry. Results: We proposed the preliminary diagnostic criteria and disease severity classification for CD based on our discussion. In addition, we made a proposal for the disease activity score. We identified clinical and pathological features of patients with iMCD diagnosed by these diagnostic criteria. In the disease severity classification, 37, 33 and 30% patients were categorized into mild, moderate and severe diseases, respectively. Conclusion: This is the first proposal for diagnosis and classification of CD by the Japanese group. Further studies are required to validate whether they can distinguish CD from other inflammatory diseases and to determine their sensitivity and specificity.

AB - Objectives: To determine the tentative diagnostic criteria and disease severity classification for Castleman disease (CD) and describe the clinical and pathologic features among human herpesvirus 8 (HHV-8) negative idiopathic multicentric CD (iMCD) in the Japanese population. Methods: We established the working groups for the research of CD in Japan and had meetings to discuss and define the tentative diagnostic criteria and disease severity classification for CD. We subsequently analyzed 142 patients classified into iMCD by using the nationwide Japanese patient registry. Results: We proposed the preliminary diagnostic criteria and disease severity classification for CD based on our discussion. In addition, we made a proposal for the disease activity score. We identified clinical and pathological features of patients with iMCD diagnosed by these diagnostic criteria. In the disease severity classification, 37, 33 and 30% patients were categorized into mild, moderate and severe diseases, respectively. Conclusion: This is the first proposal for diagnosis and classification of CD by the Japanese group. Further studies are required to validate whether they can distinguish CD from other inflammatory diseases and to determine their sensitivity and specificity.

KW - Castleman disease

KW - diagnostic criteria

KW - disease severity classification

KW - idiopathic multicentric Castleman disease

KW - TAFRO syndrome

UR - http://www.scopus.com/inward/record.url?scp=85029420540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029420540&partnerID=8YFLogxK

U2 - 10.1080/14397595.2017.1366093

DO - 10.1080/14397595.2017.1366093

M3 - Article

C2 - 28880697

AN - SCOPUS:85029420540

VL - 28

SP - 161

EP - 167

JO - Modern Rheumatology

JF - Modern Rheumatology

SN - 1439-7595

IS - 1

ER -