TY - JOUR
T1 - Tentative diagnostic criteria and disease severity classification for Castleman disease
T2 - A report of the research group on Castleman disease in Japan
AU - Fujimoto, Shino
AU - Koga, Tomohiro
AU - Kawakami, Atsushi
AU - Kawabata, Hiroshi
AU - Okamoto, Shinichiro
AU - Mizuki, Masao
AU - Yano, Shingo
AU - Ide, Makoto
AU - Uno, Kazuko
AU - Yagi, Katsumi
AU - Kojima, Toshiyuki
AU - Mizutani, Minoru
AU - Tokumine, Yukihiro
AU - Nishimoto, Norihiro
AU - Fujiwara, Hiroshi
AU - Nakatsuka, Shin ichi
AU - Shiozawa, Kazuko
AU - Iwaki, Noriko
AU - Masaki, Yasufumi
AU - Yoshizaki, Kazuyuki
N1 - Funding Information:
the Ministry of Health, Labor and Welfare, JapanThis study was supported in part by grants from the Ministry of Health, Labor and Welfare, Japan (H27-28 Nanchi, etc. (Nan)- General-002 and -008). The authors thank the patients, their families, all the investigators including Drs. Taro Masunari, Kazutoshi Aoyama (Chugoku Central Hospital), Masaru Kojima (Dokkyo Medical University), Hiroshi Doi (Ebara Hospital), Yukihiro Miyazaki (Ehime Prefectural Central Hospital), Masao Hagihara, Hua Jian, Morihiro Inoue (Eiju General Hospital), Kouichi Hirakawa (Fukuchiyama City Hospital), Hiroyuki Minemura (Fukushima Medical University), Nobuhiko Nakamura (Gifu University), Akihiko Yokohama, Takeki Mitsui, Norifumi Tsukamoto (Gunma University), Tadashi Matsumura (Himeji St. Mary’s Hospital), Hideki Goto, Koji Ogawa (Hokkaido University), Shigeki Hatanaka, Kazutaka Nishitarumizu, Yukiko Mori (Imamura Byoin Bun-in Hospital), Saiko Yoshida (Japanese Red Cross Nagoya Daini Hospital), Yoko Adachi (JCHO Kobe Central Hospital), Sato Toshinobu (JCHO Sendai Hospital), Tomiko Ryu (JCHO Tokyo Yamate Hospital), Yoko Edahiro, Michiaki Koike, Yoshitaka Sunami, (Juntendo University Shizuoka Hospital), Tomoyuki Sakai (Kanazawa Medicai University), Taku Kikuchi (Keio University), Ikuko Kubokawa (Kobe University), Katsunori Kyoda (Kouseiren Takaoka Hospital), Daisuke Wakasugi, Ritsuko Seki, Koji Nagafuji, Masaki Okamoto (Kurume University), Taichi Nakamura (Kuwana City Medical Center), Hisao Nagoshi (Kyoto Prefectural University), Takeshi Matsubara (Kyoto University), Eiko Oya (Matsusaka Chuo Hospital), Kiyoyuki Ogata (Metropolitan Research and Treatment Center for Blood Disorders), Chisato Tanihashi (Minai Seikyo Hospital), Toshio Yano, Tadashi Koike (Nagaoka Red Cross Hospital), Daisuke Ogawa (Nagasaki Prefecture Shimabara Hospital), Tomoki Origuchi (Nagasaki University), Hiroyuki Kobayashi (Nasu Red Cross Hospital), Naohiro Sekiguchi (NHO Disaster Medical Center), Sachiko Suzuki, Mitsutoshi Kurosawa (NHO Hokkaido Cancer Center), Yuto Mimura (NHO Matsumoto Medical Center), Izumi Yasumori (NHO Nagasaki Medical Center), Hiroatsu Iida (NHO Nagoya Medical Center), Akio Saito (NHO Nishigunma National Hospital), Jun Konishi, Kazutaka Sunami (NHO Okayama Medical Center), Kazue Takai, Koji Nikkuni (Niigata City General Hospital), Akihito Momoi (Niigata Prefectural Central Hospital), Jun Takizawa (Niigata University), Azusa Nagao (Ogikubo Hospital), Shin-ichi Nureki (Oita University), Sae Wada (Okayama Rosai Hospital), Yoshihiko Raita (Okinawa Prefectural Chubu Hospital), Keiko Yamagami, Ko Iida (Osaka City General Hospital), Yoshinobu Konishi (Osaka Red Cross Hospital), Masato Arao (Saitama Medical University), Tadashi Nakamura (Sakurajyuji Hospital), Masaya Mukai (Sapporo City General Hospital), Tsutomu Sato (Sapporo Medical University), Daisuke Shichi, Kenji Nara (Seirei Mikatahara General Hospital), Akemi Matsuo (Shinonoi General Hospital), Yoko Ozawa, Hiroshi Yamamoto, Hidekazu Takahashi (Shinshu University), Keiki Nagaharu, Keiki Kawakami (Suzuka General Hospital), Yasuo Hoshijima (Takamatsu Municipal Hospital), Noboru Hagino, Lisa Hirahara, Yusuke Takeshima (Teikyo University Chiba Medical Center), Sachiko Ando, Hajime Sakai (Teine Keijinkai Hospital), Tohru Takahashi (Tenshi Hospital), Mai Tanaka (The Jikei University), Hiroshi Fujii, Yoko Okitsu, Noriko Fukuhara (Tohoku University), Naoki Hayama (Tokai University), Yuko Toyoda, Masayoshi Yamanishi (Tokushukai Medical Cooperation Uji-Tokushukai Hospital), Yasuhiko Nishioka (Tokushima University), Tatsuhiko Shinohara, Ejima Masaru (Tokyo Medical and Dental University), Toshikazu Wada, Yume Nagaoka (Tokyo Medical University), Sayuri Motoomura (Tokyo Metropolitan Health and Medical Treatment Corporation Tama-Hokubu Medical Center), Keigo Setoguchi (Tokyo Metropolitan Komagome Hospital), Daisuke Mizuchi (Tokyo Teishin Hospital), Masakuni Tanimizu (Tottori Municipal Hospital), Satoru Kosugi (Toyonaka Municipal Hospital), Yusuke Takagi (Toyota Kosei Hospital), Yoshimasa Urasaki (University of Fukui), Jun Murakami (University of Toyama) and the nurses in the participating institutions of this study.
Funding Information:
This study was supported in part by grants from the Ministry of Health, Labor and Welfare, Japan (H27-28 Nanchi, etc. (Nan)-General-002 and -008).
Publisher Copyright:
© 2017 Japan College of Rheumatology.
PY - 2018/1/2
Y1 - 2018/1/2
N2 - Objectives: To determine the tentative diagnostic criteria and disease severity classification for Castleman disease (CD) and describe the clinical and pathologic features among human herpesvirus 8 (HHV-8) negative idiopathic multicentric CD (iMCD) in the Japanese population. Methods: We established the working groups for the research of CD in Japan and had meetings to discuss and define the tentative diagnostic criteria and disease severity classification for CD. We subsequently analyzed 142 patients classified into iMCD by using the nationwide Japanese patient registry. Results: We proposed the preliminary diagnostic criteria and disease severity classification for CD based on our discussion. In addition, we made a proposal for the disease activity score. We identified clinical and pathological features of patients with iMCD diagnosed by these diagnostic criteria. In the disease severity classification, 37, 33 and 30% patients were categorized into mild, moderate and severe diseases, respectively. Conclusion: This is the first proposal for diagnosis and classification of CD by the Japanese group. Further studies are required to validate whether they can distinguish CD from other inflammatory diseases and to determine their sensitivity and specificity.
AB - Objectives: To determine the tentative diagnostic criteria and disease severity classification for Castleman disease (CD) and describe the clinical and pathologic features among human herpesvirus 8 (HHV-8) negative idiopathic multicentric CD (iMCD) in the Japanese population. Methods: We established the working groups for the research of CD in Japan and had meetings to discuss and define the tentative diagnostic criteria and disease severity classification for CD. We subsequently analyzed 142 patients classified into iMCD by using the nationwide Japanese patient registry. Results: We proposed the preliminary diagnostic criteria and disease severity classification for CD based on our discussion. In addition, we made a proposal for the disease activity score. We identified clinical and pathological features of patients with iMCD diagnosed by these diagnostic criteria. In the disease severity classification, 37, 33 and 30% patients were categorized into mild, moderate and severe diseases, respectively. Conclusion: This is the first proposal for diagnosis and classification of CD by the Japanese group. Further studies are required to validate whether they can distinguish CD from other inflammatory diseases and to determine their sensitivity and specificity.
KW - Castleman disease
KW - TAFRO syndrome
KW - diagnostic criteria
KW - disease severity classification
KW - idiopathic multicentric Castleman disease
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UR - http://www.scopus.com/inward/citedby.url?scp=85029420540&partnerID=8YFLogxK
U2 - 10.1080/14397595.2017.1366093
DO - 10.1080/14397595.2017.1366093
M3 - Article
C2 - 28880697
AN - SCOPUS:85029420540
SN - 1439-7595
VL - 28
SP - 161
EP - 167
JO - Japanese Journal of Rheumatology
JF - Japanese Journal of Rheumatology
IS - 1
ER -
