TY - JOUR
T1 - Terresterol, a polyoxygenated lanostanoid, isolated from the oomycete Saprolegnia terrestris, and its innate immune-promoting activity
AU - Kikuchi, Haruhisa
AU - Sato, Yuichi
AU - Kurata, Shoichiro
AU - Katou, Yasuhiro
AU - Oshima, Yoshiteru
N1 - Funding Information:
We thank Dr. J.L. Imler for Att-luc reporter construct. This work was supported in part by Grant-in-Aid for Scientific Research (No. 23710247 ) from the Ministry of Education, Science, Sports and Culture of Japan , and the SUNBOR GRANT from the Suntory Institute for Bioorganic Research .
PY - 2013/4/29
Y1 - 2013/4/29
N2 - Oomycetes are widely spread eukaryotic microorganisms. However, there have only been a few reports on the secondary metabolites produced by them. In the course of screening for innate immune regulators from natural resources, we isolated a new polyoxygenated lanostanoid, terresterol (1), from the oomycetes Saprolegnia terrestris. Compounds bearing a 21,22,24,25-tetraoxygenated side chain similar to 1 have only been rarely described, and the isolation of such compounds shows that oomycetes are promising resources for natural product chemistry. In addition, terresterol (1) has potential to be used as a lead compound for novel immunostimulating agents against bacterial infections and as probe for the innate immune system.
AB - Oomycetes are widely spread eukaryotic microorganisms. However, there have only been a few reports on the secondary metabolites produced by them. In the course of screening for innate immune regulators from natural resources, we isolated a new polyoxygenated lanostanoid, terresterol (1), from the oomycetes Saprolegnia terrestris. Compounds bearing a 21,22,24,25-tetraoxygenated side chain similar to 1 have only been rarely described, and the isolation of such compounds shows that oomycetes are promising resources for natural product chemistry. In addition, terresterol (1) has potential to be used as a lead compound for novel immunostimulating agents against bacterial infections and as probe for the innate immune system.
KW - Immunostimulating agents
KW - Innate immunity
KW - Lanostanoid
KW - Oomycetes
KW - Structural elucidation
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U2 - 10.1016/j.tet.2013.02.088
DO - 10.1016/j.tet.2013.02.088
M3 - Article
AN - SCOPUS:84875252535
SN - 0040-4020
VL - 69
SP - 3536
EP - 3542
JO - Tetrahedron
JF - Tetrahedron
IS - 17
ER -