Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults

Tiffany W. Chow; David C. Mamo; Hiroyuki Uchida; Ariel Graff-Guerrero; Sylvain Houle; Gwenn S. Smith; Bruce G. Pollock; Benoit H. Mulsant

doi:10.1186/1471-2342-9-12

Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT_2A) receptors in older, healthy adults

Tiffany W. Chow, David C. Mamo, Hiroyuki Uchida, Ariel Graff-Guerrero, Sylvain Houle, Gwenn S. Smith, Bruce G. Pollock, Benoit H. Mulsant

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Background: Position emission tomography (PET) imaging using [¹⁸F]-setoperone to quantify cortical 5-HT_2A receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin 5HT_2A receptor (5HT_2AR) binding potential. The purpose of this study was to assess the test-retest variability of [¹⁸F]-setoperone PET with a high resolution scanner (HRRT) for measuring 5HT_2AR availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65-78 years) completed two [¹⁸F]-setoperone PET scans on two separate occasions 5-16 weeks apart. Results: The average difference in the binding potential (BP_ND) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion: We conclude that the test-retest variability of [¹⁸F]-setoperone PET in elderly subjects is comparable to that of [¹⁸F]-setoperone and other 5HT_2AR radiotracers in younger subject samples.

Original language	English
Article number	12
Journal	BMC Medical Imaging
Volume	9
DOIs	https://doi.org/10.1186/1471-2342-9-12
Publication status	Published - 2009 Jul 6
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1186/1471-2342-9-12

Cite this

@article{492b574e56424791a543b49192f1761c,

title = "Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults",

abstract = "Background: Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-HT2A receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin 5HT2A receptor (5HT2AR) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring 5HT2AR availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65-78 years) completed two [18F]-setoperone PET scans on two separate occasions 5-16 weeks apart. Results: The average difference in the binding potential (BPND) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion: We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other 5HT2AR radiotracers in younger subject samples.",

author = "Chow, {Tiffany W.} and Mamo, {David C.} and Hiroyuki Uchida and Ariel Graff-Guerrero and Sylvain Houle and Smith, {Gwenn S.} and Pollock, {Bruce G.} and Mulsant, {Benoit H.}",

note = "Funding Information: The authors gratefully acknowledge the contributions of the research staff for the Geriatric Mental Health Program and the CAMH PET Imaging Centre to subject recruitment, radiochemical synthesis and conduct of the PET studies. This work was funded by NIH grants (F32 AG022802 (TWC); MH 01621 (GSS); the University of Toronto Dean's Fund for New Faculty (#457494 TWC); an endowment to the Sam and Ida Ross Memory Clinic (TWC); the Sandra A. Rotman Chair and Program in Neuropsychiatry (BP); the Canada Foundation for Innovation and the Ontario Innovation Trust (SH).",

year = "2009",

month = jul,

day = "6",

doi = "10.1186/1471-2342-9-12",

language = "English",

volume = "9",

journal = "BMC Medical Imaging",

issn = "1471-2342",

publisher = "BioMed Central",

}

TY - JOUR

T1 - Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults

AU - Chow, Tiffany W.

AU - Mamo, David C.

AU - Uchida, Hiroyuki

AU - Graff-Guerrero, Ariel

AU - Houle, Sylvain

AU - Smith, Gwenn S.

AU - Pollock, Bruce G.

AU - Mulsant, Benoit H.

N1 - Funding Information: The authors gratefully acknowledge the contributions of the research staff for the Geriatric Mental Health Program and the CAMH PET Imaging Centre to subject recruitment, radiochemical synthesis and conduct of the PET studies. This work was funded by NIH grants (F32 AG022802 (TWC); MH 01621 (GSS); the University of Toronto Dean's Fund for New Faculty (#457494 TWC); an endowment to the Sam and Ida Ross Memory Clinic (TWC); the Sandra A. Rotman Chair and Program in Neuropsychiatry (BP); the Canada Foundation for Innovation and the Ontario Innovation Trust (SH).

PY - 2009/7/6

Y1 - 2009/7/6

N2 - Background: Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-HT2A receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin 5HT2A receptor (5HT2AR) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring 5HT2AR availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65-78 years) completed two [18F]-setoperone PET scans on two separate occasions 5-16 weeks apart. Results: The average difference in the binding potential (BPND) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion: We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other 5HT2AR radiotracers in younger subject samples.

AB - Background: Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-HT2A receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin 5HT2A receptor (5HT2AR) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring 5HT2AR availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65-78 years) completed two [18F]-setoperone PET scans on two separate occasions 5-16 weeks apart. Results: The average difference in the binding potential (BPND) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion: We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other 5HT2AR radiotracers in younger subject samples.

UR - http://www.scopus.com/inward/record.url?scp=68949211240&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68949211240&partnerID=8YFLogxK

U2 - 10.1186/1471-2342-9-12

DO - 10.1186/1471-2342-9-12

M3 - Article

C2 - 19580676

AN - SCOPUS:68949211240

SN - 1471-2342

VL - 9

JO - BMC Medical Imaging

JF - BMC Medical Imaging

M1 - 12

ER -

Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT_2A) receptors in older, healthy adults

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this