Testing the effectiveness of antiemetic guidelines: results of a prospective registry by the CINV Study Group of Japan

Kazuo Tamura, Keisuke Aiba, Toshiaki Saeki, Yoichi Nakanishi, Toshiharu Kamura, Hideo Baba, Kazuhiro Yoshida, Nobuyuki Yamamoto, Yuukou Kitagawa, Yoshihiko Maehara, Mototsugu Shimokawa, Koichi Hirata, Masaki Kitajima

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63 Citations (Scopus)

Abstract

Background: Many cancer patients suffer from the common side effect of chemotherapy-induced nausea and vomiting (CINV). Guidelines recommend a combination of two prophylactic antiemetics for moderately emetogenic chemotherapy (MEC) and three for highly emetogenic chemotherapy (HEC) and certain MEC regimens. Methods: This multicenter, prospective, observational study analyzed data for 1,910 patients in Japan scheduled for MEC or HEC. Use of antiemetic prophylaxis in relation to type of chemotherapy, incidences of and risk factors for nausea, vomiting, and acute versus delayed CINV, and estimated incidence of CINV by staff were analyzed using Fisher’s exact test and multivariate logistic regression. The patients recorded the incidence of CINV and severity of nausea by visual analogue scales daily for 7 days after receiving chemotherapy. Results: A total of 240 (20.1 %) HEC and 476 MEC patients (66.6 %) received 2 antiemetics, compared with 883 (73.9 %) and 200 (28.0 %), respectively, who received 3 antiemetics. Approximately 74 % of HEC and 95 % of MEC patients received antiemetic therapy in compliance with guidelines. Acute nausea and vomiting were well controlled, but high incidences of delayed nausea occurred in both HEC and MEC patients. Delayed vomiting (p 

Original languageEnglish
Pages (from-to)855-865
Number of pages11
JournalInternational Journal of Clinical Oncology
Volume20
Issue number5
DOIs
Publication statusPublished - 2015 Feb 15

Keywords

  • Antiemetics
  • Cancer chemotherapy
  • Guidelines
  • Nausea
  • Vomiting

ASJC Scopus subject areas

  • Oncology
  • Surgery
  • Hematology

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    Tamura, K., Aiba, K., Saeki, T., Nakanishi, Y., Kamura, T., Baba, H., Yoshida, K., Yamamoto, N., Kitagawa, Y., Maehara, Y., Shimokawa, M., Hirata, K., & Kitajima, M. (2015). Testing the effectiveness of antiemetic guidelines: results of a prospective registry by the CINV Study Group of Japan. International Journal of Clinical Oncology, 20(5), 855-865. https://doi.org/10.1007/s10147-015-0786-7