Tetrahydroswertianolin: A potent hepatoprotective agent from Swertia japonica MAKINO

Kouji Hase, Shigetoshi Kadota, Purusotam Basnet, Jianxin Li, Shuichi Takamura, Tsuneo Namba

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Tetrahydroswertianolin (1), a new tetrahydroxanthone glycoside, was isolated from the whole plant of Swertia japonica MAKINO (Gentianaceae). Its structure was determined by chemical and spectroscopic methods including 2D- NMR. This compound was found to be very effective in immunologically induced liver injury in mice.

Original languageEnglish
Pages (from-to)567-569
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume45
Issue number3
Publication statusPublished - 1997 Mar
Externally publishedYes

Fingerprint

Gentianaceae
Swertia
Glycosides
Liver
Nuclear magnetic resonance
Wounds and Injuries
tetrahydroswertianolin

Keywords

  • D- galactosamine/lipopolysaccharide-induced liver injury
  • Gentianaceae
  • Swertia japonica
  • tetrahydroswertianolin
  • tetrahydroxanthone

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Hase, K., Kadota, S., Basnet, P., Li, J., Takamura, S., & Namba, T. (1997). Tetrahydroswertianolin: A potent hepatoprotective agent from Swertia japonica MAKINO. Chemical and Pharmaceutical Bulletin, 45(3), 567-569.

Tetrahydroswertianolin : A potent hepatoprotective agent from Swertia japonica MAKINO. / Hase, Kouji; Kadota, Shigetoshi; Basnet, Purusotam; Li, Jianxin; Takamura, Shuichi; Namba, Tsuneo.

In: Chemical and Pharmaceutical Bulletin, Vol. 45, No. 3, 03.1997, p. 567-569.

Research output: Contribution to journalArticle

Hase, K, Kadota, S, Basnet, P, Li, J, Takamura, S & Namba, T 1997, 'Tetrahydroswertianolin: A potent hepatoprotective agent from Swertia japonica MAKINO', Chemical and Pharmaceutical Bulletin, vol. 45, no. 3, pp. 567-569.
Hase, Kouji ; Kadota, Shigetoshi ; Basnet, Purusotam ; Li, Jianxin ; Takamura, Shuichi ; Namba, Tsuneo. / Tetrahydroswertianolin : A potent hepatoprotective agent from Swertia japonica MAKINO. In: Chemical and Pharmaceutical Bulletin. 1997 ; Vol. 45, No. 3. pp. 567-569.
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