TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells

Hayato Takahashi, Tomohiko Kanno, Shingo Nakayamada, Kiyoshi Hirahara, Giuseppe Sciumè, Stefan A. Muljo, Stefan Kuchen, Rafael Casellas, Lai Wei, Yuka Kanno, John J. O'Shea

Research output: Contribution to journalArticlepeer-review

222 Citations (Scopus)

Abstract

Distinct CD4+ T cell subsets are critical for host defense and immunoregulation. Although these subsets can act as terminally differentiated lineages, they have been increasingly noted to demonstrated plasticity. MicroRNAs are factors that control T cell stability and plasticity. Here we report that naturally occurring regulatory T cells (Treg cells) had high expression of the microRNA miR-10a and that miR-10a was induced by retinoic acid and transforming growth factor-β (TGF-β) in inducible T reg cells. By simultaneously targeting the transcriptional repressor Bcl-6 and the corepressor Ncor2, miR-10a attenuated the phenotypic conversion of inducible Treg cells into follicular helper T cells. We also found that miR-10a limited differentiation into the TH17 subset of helper T cells and therefore represents a factor that can fine-tune the plasticity and fate of helper T cells.

Original languageEnglish
Pages (from-to)587-595
Number of pages9
JournalNature Immunology
Volume13
Issue number6
DOIs
Publication statusPublished - 2012 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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