TGF-β function in immune suppression

Akihiko Yoshimura; Go Muto

doi:10.1007/82-2010-87

TGF-β function in immune suppression

Akihiko Yoshimura, Go Muto

Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

Transforming growth factor-β (TGF-β) has been shown to play an essential role in establishing immunological tolerance, yet recent studies have revealed the pro-inflammatory roles of TGF-β in inflammatory responses. TGF-β induces Foxp3-positive regulatory T cells (iTregs), while in the presence of IL-6, it induces pathogenic IL-17 producing Th17 cells. TGF-β inhibits the proliferation of T cells as well as cytokine production via Foxp3-dependent and independent mechanisms. On the one hand, little is known about molecular mechanisms involved in immune suppression via TGF-β however, recent studies suggest that Smad2 as well as Smad3 play essential roles in Foxp3 induction and cytokine suppression, whereas Th17 differentiation is promoted via the Smad-independent pathway. Mutual suppression of signaling between TGF-β and inflammatory cytokines has been shown to be necessary for the balance of immunity and tolerance.

Original language	English
Pages (from-to)	127-147
Number of pages	21
Journal	Current topics in microbiology and immunology
Volume	350
DOIs	https://doi.org/10.1007/82-2010-87
Publication status	Published - 2010 Dec 1

ASJC Scopus subject areas

Immunology and Allergy
Microbiology
Immunology
Microbiology (medical)

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TGF-β function in immune suppression

Abstract

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