TY - JOUR
T1 - Th17 cells in inflammation
AU - Kimura, Akihiro
AU - Kishimoto, Tadamitsu
N1 - Funding Information:
We thank our colleagues in our laboratory for helpful discussion. This work was supported by the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation and Chugai-Roche Pharmaceutical Co. Ltd., Tokyo, Japan .
PY - 2011/3
Y1 - 2011/3
N2 - Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various autoimmune diseases. Although several cytokines participate in Th17 cell development, IL-6 and TGF-β are key factors for the generation of Th17 cells from naïve T cells. On the other hand, IL-6 inhibits TGF-β-induced regulatory T (Treg) cells, which suppress adaptive T cell responses and prevent autoimmunity. Recent studies suggest that it is an effective approach in the treatment of various autoimmune and inflammatory diseases to normalize the balance between Treg and Th17 cell development. Here, we review the discovery of the Th17 subset, its properties and relationship with several autoimmune diseases. Crown
AB - Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various autoimmune diseases. Although several cytokines participate in Th17 cell development, IL-6 and TGF-β are key factors for the generation of Th17 cells from naïve T cells. On the other hand, IL-6 inhibits TGF-β-induced regulatory T (Treg) cells, which suppress adaptive T cell responses and prevent autoimmunity. Recent studies suggest that it is an effective approach in the treatment of various autoimmune and inflammatory diseases to normalize the balance between Treg and Th17 cell development. Here, we review the discovery of the Th17 subset, its properties and relationship with several autoimmune diseases. Crown
KW - IL-6
KW - TGF-beta
KW - Th17
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U2 - 10.1016/j.intimp.2010.10.004
DO - 10.1016/j.intimp.2010.10.004
M3 - Article
C2 - 21035432
AN - SCOPUS:79952101377
SN - 1567-5769
VL - 11
SP - 319
EP - 322
JO - International Immunopharmacology
JF - International Immunopharmacology
IS - 3
ER -