The 2H4 molecule but not the T3-receptor complex is involved in suppressor inducer signals in the AMLR system

Tsutomu Takeuchi, Stuart F. Schlossman, Chikao Morimoto

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cells activated in AMLR were used to define the molecules important in the generation of the suppressor inducer signal. The density of a 200 220-kDa structure, termed 2H4, increased on T4 cells during activation in AMLR and furthermore a strong correlation was observed between the generated suppressor inducer activity of such cells and the density of the 2H4 antigen. More importantly, we showed that treatment of AMLR activated T4 cells with anti-2H4 but not anti-T3 or T4 antibody abolished the suppressor inducer function of these cells. These results suggest that the 2H4 molecule but not the T3-receptor complex plays an important role in generating suppressor inducer signals in the AMLR system.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalCellular Immunology
Volume107
Issue number1
DOIs
Publication statusPublished - 1987
Externally publishedYes

Fingerprint

CD3 Antigens
Thyroid Hormone Receptors
Mixed Lymphocyte Culture Test
CD4-Positive T-Lymphocytes
CD45 Antigens
Histocompatibility
Helper-Inducer T-Lymphocytes
Cell Count
Monoclonal Antibodies
Antibodies

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

The 2H4 molecule but not the T3-receptor complex is involved in suppressor inducer signals in the AMLR system. / Takeuchi, Tsutomu; Schlossman, Stuart F.; Morimoto, Chikao.

In: Cellular Immunology, Vol. 107, No. 1, 1987, p. 107-114.

Research output: Contribution to journalArticle

@article{7831a8a397d84bbf84abb6bb601b0592,
title = "The 2H4 molecule but not the T3-receptor complex is involved in suppressor inducer signals in the AMLR system",
abstract = "It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cells activated in AMLR were used to define the molecules important in the generation of the suppressor inducer signal. The density of a 200 220-kDa structure, termed 2H4, increased on T4 cells during activation in AMLR and furthermore a strong correlation was observed between the generated suppressor inducer activity of such cells and the density of the 2H4 antigen. More importantly, we showed that treatment of AMLR activated T4 cells with anti-2H4 but not anti-T3 or T4 antibody abolished the suppressor inducer function of these cells. These results suggest that the 2H4 molecule but not the T3-receptor complex plays an important role in generating suppressor inducer signals in the AMLR system.",
author = "Tsutomu Takeuchi and Schlossman, {Stuart F.} and Chikao Morimoto",
year = "1987",
doi = "10.1016/0008-8749(87)90270-X",
language = "English",
volume = "107",
pages = "107--114",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - The 2H4 molecule but not the T3-receptor complex is involved in suppressor inducer signals in the AMLR system

AU - Takeuchi, Tsutomu

AU - Schlossman, Stuart F.

AU - Morimoto, Chikao

PY - 1987

Y1 - 1987

N2 - It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cells activated in AMLR were used to define the molecules important in the generation of the suppressor inducer signal. The density of a 200 220-kDa structure, termed 2H4, increased on T4 cells during activation in AMLR and furthermore a strong correlation was observed between the generated suppressor inducer activity of such cells and the density of the 2H4 antigen. More importantly, we showed that treatment of AMLR activated T4 cells with anti-2H4 but not anti-T3 or T4 antibody abolished the suppressor inducer function of these cells. These results suggest that the 2H4 molecule but not the T3-receptor complex plays an important role in generating suppressor inducer signals in the AMLR system.

AB - It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cells activated in AMLR were used to define the molecules important in the generation of the suppressor inducer signal. The density of a 200 220-kDa structure, termed 2H4, increased on T4 cells during activation in AMLR and furthermore a strong correlation was observed between the generated suppressor inducer activity of such cells and the density of the 2H4 antigen. More importantly, we showed that treatment of AMLR activated T4 cells with anti-2H4 but not anti-T3 or T4 antibody abolished the suppressor inducer function of these cells. These results suggest that the 2H4 molecule but not the T3-receptor complex plays an important role in generating suppressor inducer signals in the AMLR system.

UR - http://www.scopus.com/inward/record.url?scp=0023229023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023229023&partnerID=8YFLogxK

U2 - 10.1016/0008-8749(87)90270-X

DO - 10.1016/0008-8749(87)90270-X

M3 - Article

VL - 107

SP - 107

EP - 114

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

IS - 1

ER -