[The ACE2/Ang(1-7)/Mas receptor axis in cardiovascular and renal diseases].

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5 Citations (Scopus)

Abstract

The renin-angiotensin-aldosterone system(RAAS) plays a crucial role in the regulation of physiological homeostasis and diseases such as hypertension, coronary artery disease and chronic renal failure. In this cascade, the ACE/Ang II/AT1 receptor axis induces pathological effects, such as vasoconstriction, cell proliferation and fibrosis. Recently the ACE2/Ang(1-7)/Mas receptor axis has been recognized as a negative regulator of the RAAS. ACE2 metabolizes Ang II into Ang(1-7), which has opposite properties of Ang II through Mas receptor activation. Both animal and human studies provide strong evidence that the ACE2/Ang(1-7)/Mas receptor axis is protective for end-organ damage. Therefore, the ACE2/Ang(1-7)/Mas receptor axis could be a therapeutic target for coronary artery disease and chronic renal failure.

Original languageEnglish
Pages (from-to)1487-1491
Number of pages5
JournalNihon rinsho. Japanese journal of clinical medicine
Volume70
Issue number9
Publication statusPublished - 2012 Sep

Fingerprint

Renin-Angiotensin System
Chronic Kidney Failure
Coronary Artery Disease
Cardiovascular Diseases
Kidney
Vasoconstriction
Homeostasis
Fibrosis
Cell Proliferation
Hypertension
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "The renin-angiotensin-aldosterone system(RAAS) plays a crucial role in the regulation of physiological homeostasis and diseases such as hypertension, coronary artery disease and chronic renal failure. In this cascade, the ACE/Ang II/AT1 receptor axis induces pathological effects, such as vasoconstriction, cell proliferation and fibrosis. Recently the ACE2/Ang(1-7)/Mas receptor axis has been recognized as a negative regulator of the RAAS. ACE2 metabolizes Ang II into Ang(1-7), which has opposite properties of Ang II through Mas receptor activation. Both animal and human studies provide strong evidence that the ACE2/Ang(1-7)/Mas receptor axis is protective for end-organ damage. Therefore, the ACE2/Ang(1-7)/Mas receptor axis could be a therapeutic target for coronary artery disease and chronic renal failure.",
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