The added value of tomosynthesis in endoscopic retrograde cholangiography with radiography for the detection of choledocholithiasis

Yohsuke Suyama, Yoshitake Yamada, Hideki Yamaguchi, Gou Someya, Seiji Otsuka, Yoshitami Murayama, Hiroshi Shinmoto, Masahiro Jinzaki, Kenji Ogawa

Research output: Contribution to journalArticle

Abstract

Objective: The diagnostic performance of endoscopic retrograde cholangiography (ERC) with radiography is imperfect. We assessed the value of adding tomosynthesis to ERC with radiography for the detection of choledocholithiasis. Methods: This study included 102 consecutive patients (choledocholithiasis/non-choledocholithiasis, n = 57/45), who underwent both radiography and tomosynthesis for ERC in the same examination and were not diagnosed with malignancy. The reference standard for the existence of choledocholithiasis was confirmed by endoscopic stone extraction during ERC, intraoperative cholangiography, or follow up with magnetic resonance cholangiopancreatography (n = 78, 11, and 13, respectively). A gastroenterologist and a radiologist independently evaluated the radiographs and the combination of tomosynthesis and radiographic images in a blinded and randomised manner. Receiver operating characteristic analysis was used for statistical analysis. Results: The areas under the receiver operating characteristic curve for combined tomosynthesis and radiography were significantly higher than those for radiography alone for both readers: Reader 1/ Reader 2, 0.929/0.956 [95% confidence interval (CI), 0.861-0.965/0.890-0.983) vs 0.803/0.769 (95% confidence interval, 0.707-0.873/0.668-0.846), respectively (p = 0.0047/> 0.0001). Conclusion: Adding tomosynthesis to radiography improved the diagnostic performance of ERC for detection of choledocholithiasis. Advances in knowledge: Adding tomosynthesis to radiography improves detection of choledocholithiasis and tomosynthesis images can be obtained easily after radiographs and repeated immediately.

Original languageEnglish
Article number20180115
JournalBritish Journal of Radiology
Volume91
Issue number1087
DOIs
Publication statusPublished - 2018 Jan 1

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Choledocholithiasis
Cholangiography
Radiography
ROC Curve
Magnetic Resonance Cholangiopancreatography
Confidence Intervals

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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The added value of tomosynthesis in endoscopic retrograde cholangiography with radiography for the detection of choledocholithiasis. / Suyama, Yohsuke; Yamada, Yoshitake; Yamaguchi, Hideki; Someya, Gou; Otsuka, Seiji; Murayama, Yoshitami; Shinmoto, Hiroshi; Jinzaki, Masahiro; Ogawa, Kenji.

In: British Journal of Radiology, Vol. 91, No. 1087, 20180115, 01.01.2018.

Research output: Contribution to journalArticle

Suyama, Yohsuke ; Yamada, Yoshitake ; Yamaguchi, Hideki ; Someya, Gou ; Otsuka, Seiji ; Murayama, Yoshitami ; Shinmoto, Hiroshi ; Jinzaki, Masahiro ; Ogawa, Kenji. / The added value of tomosynthesis in endoscopic retrograde cholangiography with radiography for the detection of choledocholithiasis. In: British Journal of Radiology. 2018 ; Vol. 91, No. 1087.
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abstract = "Objective: The diagnostic performance of endoscopic retrograde cholangiography (ERC) with radiography is imperfect. We assessed the value of adding tomosynthesis to ERC with radiography for the detection of choledocholithiasis. Methods: This study included 102 consecutive patients (choledocholithiasis/non-choledocholithiasis, n = 57/45), who underwent both radiography and tomosynthesis for ERC in the same examination and were not diagnosed with malignancy. The reference standard for the existence of choledocholithiasis was confirmed by endoscopic stone extraction during ERC, intraoperative cholangiography, or follow up with magnetic resonance cholangiopancreatography (n = 78, 11, and 13, respectively). A gastroenterologist and a radiologist independently evaluated the radiographs and the combination of tomosynthesis and radiographic images in a blinded and randomised manner. Receiver operating characteristic analysis was used for statistical analysis. Results: The areas under the receiver operating characteristic curve for combined tomosynthesis and radiography were significantly higher than those for radiography alone for both readers: Reader 1/ Reader 2, 0.929/0.956 [95{\%} confidence interval (CI), 0.861-0.965/0.890-0.983) vs 0.803/0.769 (95{\%} confidence interval, 0.707-0.873/0.668-0.846), respectively (p = 0.0047/> 0.0001). Conclusion: Adding tomosynthesis to radiography improved the diagnostic performance of ERC for detection of choledocholithiasis. Advances in knowledge: Adding tomosynthesis to radiography improves detection of choledocholithiasis and tomosynthesis images can be obtained easily after radiographs and repeated immediately.",
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AU - Otsuka, Seiji

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AU - Shinmoto, Hiroshi

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