The aldol type reaction catalyzed by arylmalonate decarboxylase - A decarboxylase can catalyze an entirely different reaction, aldol reaction

Yosuke Terao, Kenji Miyamoto, Hiromichi Ohta

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The catalytic promiscuity of AMDase was demonstrated using a well-designed substrate based on the consideration of the reaction mechanism. As the reaction catalyzed by AMDase is supposed to proceed via an enolate intermediate, we expected that the enzyme promotes the aldol type reaction when an acceptor is properly arranged, which turned out to be true.

Original languageEnglish
Pages (from-to)420-421
Number of pages2
JournalChemistry Letters
Volume36
Issue number3
DOIs
Publication statusPublished - 2007 Mar 5

ASJC Scopus subject areas

  • Chemistry(all)

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