The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system

Jean Paul Misson, Christopher P. Austin, Takao Takahashi, Constance L. Cepko, Verne S. Caviness

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

The direction of neural cell migration in relation to the pattern of alignment of adjacent radial glial fibers has been studied in the developing neopallium of embryonic days 16-18 mouse embryos. The radial glial fibers were stained with RC2, a monoclonal antibody selective for cells of astroglial lineage in the developing murine brain. Migrating neural cells were stained histochemically with 5-bromo-4-chloro-3-indolyl-β-D-galactopyranoside (X-gal) following retroviral transduction of the gene encoding β-galactosidase into proliferating progenitors on E13. The leading processes and, generally, the somata of migrating neurons were found to be aligned in parallel with the radial glial fibers, despite substantial variations in the patterns of alignment of the fiber fascicles. The set of observations is consistent with the hypothesis that neural cell migration is supported by radial glial fibers.

Original languageEnglish
Pages (from-to)221-229
Number of pages9
JournalCerebral Cortex
Volume1
Issue number3
Publication statusPublished - 1991
Externally publishedYes

Fingerprint

Neuroglia
Alignment
Fiber
Fibers
Cell
Cell Migration
Cell Movement
Galactosidases
Neocortex
Carisoprodol
Cell Lineage
Galactose
Gene encoding
Monoclonal antibodies
Monoclonal Antibody
Embryo
Embryonic Structures
Monoclonal Antibodies
Neurons
Mouse

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience

Cite this

Misson, J. P., Austin, C. P., Takahashi, T., Cepko, C. L., & Caviness, V. S. (1991). The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system. Cerebral Cortex, 1(3), 221-229.

The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system. / Misson, Jean Paul; Austin, Christopher P.; Takahashi, Takao; Cepko, Constance L.; Caviness, Verne S.

In: Cerebral Cortex, Vol. 1, No. 3, 1991, p. 221-229.

Research output: Contribution to journalArticle

Misson, JP, Austin, CP, Takahashi, T, Cepko, CL & Caviness, VS 1991, 'The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system', Cerebral Cortex, vol. 1, no. 3, pp. 221-229.
Misson, Jean Paul ; Austin, Christopher P. ; Takahashi, Takao ; Cepko, Constance L. ; Caviness, Verne S. / The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system. In: Cerebral Cortex. 1991 ; Vol. 1, No. 3. pp. 221-229.
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