The antiaging approach for the treatment of dry eye

Kazuo Tsubota, Motoko Kawashima, Takaaki Inaba, Murat Dogru, Yukihiro Matsumoto, Reiko Ishida, Minako Kaido, Takashi Kojima, Miki Uchino, Yuichi Uchino, Yoko Ogawa, Shigeru Nakamura, Akihiro Higuchi, Ken Shinmura, Mitsuhiro Watanabe, Tetsuya Kawakita

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

ABSTRACT:: Dry eye is one of the most common eye disorders affecting millions of people. It causes ocular irritation or discomfort, and decreases functional vision, causing a dramatic deterioration in the quality of life. Although new treatments such as the P2Y2 agonist or cyclosporine eye drops have been developed and a certain level of patient satisfaction can now be obtained, no fundamental treatment has been developed. Currently, there is no therapy available to recover lacrimal function to its normal status. Recent progress in the understanding of aging has laid the foundations for a new way of thinking about intervention of the aging process. Because dry eye is accelerated by aging, a useful approach for the prevention or treatment of dry eye may be to interfere with the aging process. In the scientific community, there is a global consensus that calorie restriction can extend the life span of various kinds of animals, establishing an intervention to aging. Another important hypothesis believed to be involved in aging is the free radical theory. According to these theories, the aging process may be managed by controlling levels of calories or reactive oxygen species. In this review, these 2 important aging theories, calorie restriction and free radical aging, are examined, and we discuss how to apply these theories to the prevention and treatment of dry eye.

Original languageEnglish
JournalCornea
Volume31
Issue number11 SUPPL.1
DOIs
Publication statusPublished - 2012 Nov

Fingerprint

Free Radicals
Therapeutics
Ophthalmic Solutions
Tears
Patient Satisfaction
Cyclosporine
Reactive Oxygen Species
Consensus
Quality of Life
Thinking

Keywords

  • aging
  • calorie restriction
  • dry eye
  • reactive oxygen species

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Tsubota, K., Kawashima, M., Inaba, T., Dogru, M., Matsumoto, Y., Ishida, R., ... Kawakita, T. (2012). The antiaging approach for the treatment of dry eye. Cornea, 31(11 SUPPL.1). https://doi.org/10.1097/ICO.0b013e31826a05a8

The antiaging approach for the treatment of dry eye. / Tsubota, Kazuo; Kawashima, Motoko; Inaba, Takaaki; Dogru, Murat; Matsumoto, Yukihiro; Ishida, Reiko; Kaido, Minako; Kojima, Takashi; Uchino, Miki; Uchino, Yuichi; Ogawa, Yoko; Nakamura, Shigeru; Higuchi, Akihiro; Shinmura, Ken; Watanabe, Mitsuhiro; Kawakita, Tetsuya.

In: Cornea, Vol. 31, No. 11 SUPPL.1, 11.2012.

Research output: Contribution to journalArticle

Tsubota, K, Kawashima, M, Inaba, T, Dogru, M, Matsumoto, Y, Ishida, R, Kaido, M, Kojima, T, Uchino, M, Uchino, Y, Ogawa, Y, Nakamura, S, Higuchi, A, Shinmura, K, Watanabe, M & Kawakita, T 2012, 'The antiaging approach for the treatment of dry eye', Cornea, vol. 31, no. 11 SUPPL.1. https://doi.org/10.1097/ICO.0b013e31826a05a8
Tsubota K, Kawashima M, Inaba T, Dogru M, Matsumoto Y, Ishida R et al. The antiaging approach for the treatment of dry eye. Cornea. 2012 Nov;31(11 SUPPL.1). https://doi.org/10.1097/ICO.0b013e31826a05a8
Tsubota, Kazuo ; Kawashima, Motoko ; Inaba, Takaaki ; Dogru, Murat ; Matsumoto, Yukihiro ; Ishida, Reiko ; Kaido, Minako ; Kojima, Takashi ; Uchino, Miki ; Uchino, Yuichi ; Ogawa, Yoko ; Nakamura, Shigeru ; Higuchi, Akihiro ; Shinmura, Ken ; Watanabe, Mitsuhiro ; Kawakita, Tetsuya. / The antiaging approach for the treatment of dry eye. In: Cornea. 2012 ; Vol. 31, No. 11 SUPPL.1.
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