The apolipoprotein E gene in Binswanger's disease and vascular dementia

Susumu Higuchi; Hiroyuki Arai; Takuma Nakagawa; Taro Muramatsu; Hidetada Sasaki; John Q. Trojanowski

doi:10.1111/j.1399-0004.1996.tb02712.x

The apolipoprotein E gene in Binswanger's disease and vascular dementia

Susumu Higuchi, Hiroyuki Arai, Takuma Nakagawa, Taro Muramatsu, Hidetada Sasaki, John Q. Trojanowski

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

We investigated the polymorphism of the apolipoprotein E (ApoE) gene using a PCR-RFLP method in patients with Binswanger's disease (BD), non-BD vascular dementia, or Alzheimer's disease (AD). The frequency of the ε4 allele of the ApoE (ApoE4) in BD patients and non-BD vascular dementia patients did not differ from that observed in the non-demented elderly controls, but it was significantly lower than the frequency in AD patients. These results and other recent observations suggest that one or more factors other than the ApoE gene contribute to the pathogenesis of dementia in BD and non-BD vascular dementia.

Original language	English
Pages (from-to)	459-461
Number of pages	3
Journal	Clinical Genetics
Volume	50
Issue number	6
DOIs	https://doi.org/10.1111/j.1399-0004.1996.tb02712.x
Publication status	Published - 1996 Dec
Externally published	Yes

Keywords

Alzheimer's disease
Apolipoprotein E
Binswanger's disease
Polymorphism
Vascular dementia

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Access to Document

10.1111/j.1399-0004.1996.tb02712.x

Cite this

@article{da515e6d922d46a290fea36824f9356f,

title = "The apolipoprotein E gene in Binswanger's disease and vascular dementia",

abstract = "We investigated the polymorphism of the apolipoprotein E (ApoE) gene using a PCR-RFLP method in patients with Binswanger's disease (BD), non-BD vascular dementia, or Alzheimer's disease (AD). The frequency of the ε4 allele of the ApoE (ApoE4) in BD patients and non-BD vascular dementia patients did not differ from that observed in the non-demented elderly controls, but it was significantly lower than the frequency in AD patients. These results and other recent observations suggest that one or more factors other than the ApoE gene contribute to the pathogenesis of dementia in BD and non-BD vascular dementia.",

keywords = "Alzheimer's disease, Apolipoprotein E, Binswanger's disease, Polymorphism, Vascular dementia",

author = "Susumu Higuchi and Hiroyuki Arai and Takuma Nakagawa and Taro Muramatsu and Hidetada Sasaki and Trojanowski, {John Q.}",

year = "1996",

month = dec,

doi = "10.1111/j.1399-0004.1996.tb02712.x",

language = "English",

volume = "50",

pages = "459--461",

journal = "Clinical Genetics",

issn = "0009-9163",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - The apolipoprotein E gene in Binswanger's disease and vascular dementia

AU - Higuchi, Susumu

AU - Arai, Hiroyuki

AU - Nakagawa, Takuma

AU - Muramatsu, Taro

AU - Sasaki, Hidetada

AU - Trojanowski, John Q.

PY - 1996/12

Y1 - 1996/12

N2 - We investigated the polymorphism of the apolipoprotein E (ApoE) gene using a PCR-RFLP method in patients with Binswanger's disease (BD), non-BD vascular dementia, or Alzheimer's disease (AD). The frequency of the ε4 allele of the ApoE (ApoE4) in BD patients and non-BD vascular dementia patients did not differ from that observed in the non-demented elderly controls, but it was significantly lower than the frequency in AD patients. These results and other recent observations suggest that one or more factors other than the ApoE gene contribute to the pathogenesis of dementia in BD and non-BD vascular dementia.

AB - We investigated the polymorphism of the apolipoprotein E (ApoE) gene using a PCR-RFLP method in patients with Binswanger's disease (BD), non-BD vascular dementia, or Alzheimer's disease (AD). The frequency of the ε4 allele of the ApoE (ApoE4) in BD patients and non-BD vascular dementia patients did not differ from that observed in the non-demented elderly controls, but it was significantly lower than the frequency in AD patients. These results and other recent observations suggest that one or more factors other than the ApoE gene contribute to the pathogenesis of dementia in BD and non-BD vascular dementia.

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Binswanger's disease

KW - Polymorphism

KW - Vascular dementia

UR - http://www.scopus.com/inward/record.url?scp=0030481880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030481880&partnerID=8YFLogxK

U2 - 10.1111/j.1399-0004.1996.tb02712.x

DO - 10.1111/j.1399-0004.1996.tb02712.x

M3 - Article

C2 - 9147873

AN - SCOPUS:0030481880

SN - 0009-9163

VL - 50

SP - 459

EP - 461

JO - Clinical Genetics

JF - Clinical Genetics

IS - 6

ER -

The apolipoprotein E gene in Binswanger's disease and vascular dementia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this