The apolipoprotein E gene in Binswanger's disease and vascular dementia

Susumu Higuchi, Hiroyuki Arai, Takuma Nakagawa, Taro Muramatsu, Hidetada Sasaki, John Q. Trojanowski

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We investigated the polymorphism of the apolipoprotein E (ApoE) gene using a PCR-RFLP method in patients with Binswanger's disease (BD), non-BD vascular dementia, or Alzheimer's disease (AD). The frequency of the ε4 allele of the ApoE (ApoE4) in BD patients and non-BD vascular dementia patients did not differ from that observed in the non-demented elderly controls, but it was significantly lower than the frequency in AD patients. These results and other recent observations suggest that one or more factors other than the ApoE gene contribute to the pathogenesis of dementia in BD and non-BD vascular dementia.

Original languageEnglish
Pages (from-to)459-461
Number of pages3
JournalClinical Genetics
Volume50
Issue number6
Publication statusPublished - 1996 Dec
Externally publishedYes

Fingerprint

Vascular Dementia
Apolipoproteins E
Genes
Apolipoprotein E4
Alzheimer Disease
Vascular Diseases
Gene Frequency
Restriction Fragment Length Polymorphisms
Dementia
Polymerase Chain Reaction

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Binswanger's disease
  • Polymorphism
  • Vascular dementia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Higuchi, S., Arai, H., Nakagawa, T., Muramatsu, T., Sasaki, H., & Trojanowski, J. Q. (1996). The apolipoprotein E gene in Binswanger's disease and vascular dementia. Clinical Genetics, 50(6), 459-461.

The apolipoprotein E gene in Binswanger's disease and vascular dementia. / Higuchi, Susumu; Arai, Hiroyuki; Nakagawa, Takuma; Muramatsu, Taro; Sasaki, Hidetada; Trojanowski, John Q.

In: Clinical Genetics, Vol. 50, No. 6, 12.1996, p. 459-461.

Research output: Contribution to journalArticle

Higuchi, S, Arai, H, Nakagawa, T, Muramatsu, T, Sasaki, H & Trojanowski, JQ 1996, 'The apolipoprotein E gene in Binswanger's disease and vascular dementia', Clinical Genetics, vol. 50, no. 6, pp. 459-461.
Higuchi S, Arai H, Nakagawa T, Muramatsu T, Sasaki H, Trojanowski JQ. The apolipoprotein E gene in Binswanger's disease and vascular dementia. Clinical Genetics. 1996 Dec;50(6):459-461.
Higuchi, Susumu ; Arai, Hiroyuki ; Nakagawa, Takuma ; Muramatsu, Taro ; Sasaki, Hidetada ; Trojanowski, John Q. / The apolipoprotein E gene in Binswanger's disease and vascular dementia. In: Clinical Genetics. 1996 ; Vol. 50, No. 6. pp. 459-461.
@article{da515e6d922d46a290fea36824f9356f,
title = "The apolipoprotein E gene in Binswanger's disease and vascular dementia",
abstract = "We investigated the polymorphism of the apolipoprotein E (ApoE) gene using a PCR-RFLP method in patients with Binswanger's disease (BD), non-BD vascular dementia, or Alzheimer's disease (AD). The frequency of the ε4 allele of the ApoE (ApoE4) in BD patients and non-BD vascular dementia patients did not differ from that observed in the non-demented elderly controls, but it was significantly lower than the frequency in AD patients. These results and other recent observations suggest that one or more factors other than the ApoE gene contribute to the pathogenesis of dementia in BD and non-BD vascular dementia.",
keywords = "Alzheimer's disease, Apolipoprotein E, Binswanger's disease, Polymorphism, Vascular dementia",
author = "Susumu Higuchi and Hiroyuki Arai and Takuma Nakagawa and Taro Muramatsu and Hidetada Sasaki and Trojanowski, {John Q.}",
year = "1996",
month = "12",
language = "English",
volume = "50",
pages = "459--461",
journal = "Clinical Genetics",
issn = "0009-9163",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - The apolipoprotein E gene in Binswanger's disease and vascular dementia

AU - Higuchi, Susumu

AU - Arai, Hiroyuki

AU - Nakagawa, Takuma

AU - Muramatsu, Taro

AU - Sasaki, Hidetada

AU - Trojanowski, John Q.

PY - 1996/12

Y1 - 1996/12

N2 - We investigated the polymorphism of the apolipoprotein E (ApoE) gene using a PCR-RFLP method in patients with Binswanger's disease (BD), non-BD vascular dementia, or Alzheimer's disease (AD). The frequency of the ε4 allele of the ApoE (ApoE4) in BD patients and non-BD vascular dementia patients did not differ from that observed in the non-demented elderly controls, but it was significantly lower than the frequency in AD patients. These results and other recent observations suggest that one or more factors other than the ApoE gene contribute to the pathogenesis of dementia in BD and non-BD vascular dementia.

AB - We investigated the polymorphism of the apolipoprotein E (ApoE) gene using a PCR-RFLP method in patients with Binswanger's disease (BD), non-BD vascular dementia, or Alzheimer's disease (AD). The frequency of the ε4 allele of the ApoE (ApoE4) in BD patients and non-BD vascular dementia patients did not differ from that observed in the non-demented elderly controls, but it was significantly lower than the frequency in AD patients. These results and other recent observations suggest that one or more factors other than the ApoE gene contribute to the pathogenesis of dementia in BD and non-BD vascular dementia.

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Binswanger's disease

KW - Polymorphism

KW - Vascular dementia

UR - http://www.scopus.com/inward/record.url?scp=0030481880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030481880&partnerID=8YFLogxK

M3 - Article

C2 - 9147873

AN - SCOPUS:0030481880

VL - 50

SP - 459

EP - 461

JO - Clinical Genetics

JF - Clinical Genetics

SN - 0009-9163

IS - 6

ER -