The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

Hiroaki Suzuki, Megumi Kurita, Kiyohisa Mizumoto, Masatsugu Moriyama, Sadakazu Aiso, Ikuo Nishimoto, Masaaki Matsuoka

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11 Citations (Scopus)

Abstract

The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19 ARF or human p14 ARF binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.

Original languageEnglish
Pages (from-to)242-248
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume326
Issue number1
DOIs
Publication statusPublished - 2004 Dec 31

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Keywords

  • ARF
  • BCL6
  • Tumor suppressor
  • p14
  • p19

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Suzuki, H., Kurita, M., Mizumoto, K., Moriyama, M., Aiso, S., Nishimoto, I., & Matsuoka, M. (2004). The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression. Biochemical and Biophysical Research Communications, 326(1), 242-248. https://doi.org/10.1016/j.bbrc.2004.11.016