The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

Hiroaki Suzuki; Megumi Kurita; Kiyohisa Mizumoto; Masatsugu Moriyama; Sadakazu Aiso; Ikuo Nishimoto; Masaaki Matsuoka

doi:10.1016/j.bbrc.2004.11.016

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

Hiroaki Suzuki, Megumi Kurita, Kiyohisa Mizumoto, Masatsugu Moriyama, Sadakazu Aiso, Ikuo Nishimoto, Masaaki Matsuoka

Department of Anatomy

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19 ^ARF or human p14 ^ARF binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.

Original language	English
Pages (from-to)	242-248
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	326
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2004.11.016
Publication status	Published - 2004 Dec 31

Keywords

ARF
BCL6
Tumor suppressor
p14
p19

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2004.11.016

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title = "The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression",

abstract = "The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19 ARF or human p14 ARF binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.",

keywords = "ARF, BCL6, Tumor suppressor, p14, p19",

author = "Hiroaki Suzuki and Megumi Kurita and Kiyohisa Mizumoto and Masatsugu Moriyama and Sadakazu Aiso and Ikuo Nishimoto and Masaaki Matsuoka",

note = "Funding Information: We are indebted to Dr. Masaki Kitajima for essential support to this study. We thank Dr. V.J. Bardwell for the plasmid encoding BCL6, Drs. T. Tokuhisa and M. Hatano for the 2× BS-Luc plasmid, Drs. C.J. Sherr and M.F. Roussel for MEFs. We are indebted to Tomo Yoshida, Takako Hiraki, and Dovie Wylie for expert technical assistance. This work was supported in part by Japan Society for the Promotion of Science.",

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doi = "10.1016/j.bbrc.2004.11.016",

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AU - Suzuki, Hiroaki

AU - Kurita, Megumi

AU - Mizumoto, Kiyohisa

AU - Moriyama, Masatsugu

AU - Aiso, Sadakazu

AU - Nishimoto, Ikuo

AU - Matsuoka, Masaaki

N1 - Funding Information: We are indebted to Dr. Masaki Kitajima for essential support to this study. We thank Dr. V.J. Bardwell for the plasmid encoding BCL6, Drs. T. Tokuhisa and M. Hatano for the 2× BS-Luc plasmid, Drs. C.J. Sherr and M.F. Roussel for MEFs. We are indebted to Tomo Yoshida, Takako Hiraki, and Dovie Wylie for expert technical assistance. This work was supported in part by Japan Society for the Promotion of Science.

PY - 2004/12/31

Y1 - 2004/12/31

N2 - The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19 ARF or human p14 ARF binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.

AB - The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19 ARF or human p14 ARF binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.

KW - ARF

KW - BCL6

KW - Tumor suppressor

KW - p14

KW - p19

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

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ER -

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

Abstract

Keywords

ASJC Scopus subject areas

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