The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs

Yuko Atsumi, Aki Inase, Tomoyuki Osawa, Eiji Sugihara, Ryo Sakasai, Hiroaki Fujimori, Hirobumi Teraoka, Hideyuki Saya, Masamoto Kanno, Fumio Tashiro, Hitoshi Nakagama, Mitsuko Masutani, Ken Ichi Yoshioka

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: It is unclear how DNA-damaging agents target cancer cells over normal somatic cells. Results: Arf/p53-dependent down-regulation of H2AX enables normal cells to survive after DNA damage. Conclusion: Transformed cells, which harbor mutations in either Arf or p53, are more sensitive to DNA-damaging agents. Significance: Cellular transformation renders cells more susceptible to some DNA-damaging agents.

Original languageEnglish
Pages (from-to)13269-13277
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number19
DOIs
Publication statusPublished - 2013 May 10

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Atsumi, Y., Inase, A., Osawa, T., Sugihara, E., Sakasai, R., Fujimori, H., Teraoka, H., Saya, H., Kanno, M., Tashiro, F., Nakagama, H., Masutani, M., & Yoshioka, K. I. (2013). The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs. Journal of Biological Chemistry, 288(19), 13269-13277. https://doi.org/10.1074/jbc.M112.402560