The Association between Depressive Symptoms and Age in Cancer Patients: A Multicenter Cross-Sectional Study

Saho Wada, Ken Shimizu, Hironobu Inoguchi, Haruki Shimoda, Kazuhiro Yoshiuchi, Tatsuo Akechi, Megumi Uchida, Asao Ogawa, Daisuke Fujisawa, Shinichirou Inoue, Yosuke Uchitomi, Eisuke Matsushima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Context There is controversy around the association between depressive symptoms and age in adult cancer patients. Objectives The aim of this study was to evaluate the following hypotheses: 1) cancer patients' depressive symptoms decrease with age, and 2) in individuals aged 65 years or older, depressive symptoms increase because of the effect of somatic symptoms. Methods We retrospectively analyzed a database of 356 cancer patients who were consecutively recruited in a previous multicenter cross-sectional study. Depressive symptoms were assessed by the Patient Health Questionnaire-9 (PHQ-9), and correlations with age and other factors were assessed by hierarchical multivariate regression analysis. Age was entered as the dependent variable in the first step, patient characteristics and cancer-related variables were entered in the second step, and somatic symptoms were entered in the last step. We analyzed this model for both the total sample and the subpopulation aged 65 years or older. Results In the total sample, the PHQ-9 score was significantly associated with lower age, fatigue, and shortness of breath (adjusted R2 14.2%). In the subpopulation aged 65 years or older, no factor was associated with the PHQ-9 score (adjusted R2 7.3%). Conclusion The finding that depressive symptoms in cancer patients decreased with age was concordant with our first hypothesis, but the second hypothesis was not supported. Younger cancer patients were vulnerable to depressive symptoms and should be monitored carefully. Further studies using more representative samples are needed to examine in detail the association between depressive symptoms and age in older cancer patients.

Original languageEnglish
Pages (from-to)768-777
Number of pages10
JournalJournal of Pain and Symptom Management
Volume50
Issue number6
DOIs
Publication statusPublished - 2015 Dec 1
Externally publishedYes

Fingerprint

Cross-Sectional Studies
Depression
Neoplasms
Health
Age Factors
Dyspnea
Fatigue
Multivariate Analysis
Regression Analysis
Databases
Surveys and Questionnaires

Keywords

  • Age
  • cancer
  • depression
  • oncology
  • somatic symptoms

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Nursing(all)

Cite this

The Association between Depressive Symptoms and Age in Cancer Patients : A Multicenter Cross-Sectional Study. / Wada, Saho; Shimizu, Ken; Inoguchi, Hironobu; Shimoda, Haruki; Yoshiuchi, Kazuhiro; Akechi, Tatsuo; Uchida, Megumi; Ogawa, Asao; Fujisawa, Daisuke; Inoue, Shinichirou; Uchitomi, Yosuke; Matsushima, Eisuke.

In: Journal of Pain and Symptom Management, Vol. 50, No. 6, 01.12.2015, p. 768-777.

Research output: Contribution to journalArticle

Wada, S, Shimizu, K, Inoguchi, H, Shimoda, H, Yoshiuchi, K, Akechi, T, Uchida, M, Ogawa, A, Fujisawa, D, Inoue, S, Uchitomi, Y & Matsushima, E 2015, 'The Association between Depressive Symptoms and Age in Cancer Patients: A Multicenter Cross-Sectional Study', Journal of Pain and Symptom Management, vol. 50, no. 6, pp. 768-777. https://doi.org/10.1016/j.jpainsymman.2015.07.011
Wada, Saho ; Shimizu, Ken ; Inoguchi, Hironobu ; Shimoda, Haruki ; Yoshiuchi, Kazuhiro ; Akechi, Tatsuo ; Uchida, Megumi ; Ogawa, Asao ; Fujisawa, Daisuke ; Inoue, Shinichirou ; Uchitomi, Yosuke ; Matsushima, Eisuke. / The Association between Depressive Symptoms and Age in Cancer Patients : A Multicenter Cross-Sectional Study. In: Journal of Pain and Symptom Management. 2015 ; Vol. 50, No. 6. pp. 768-777.
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abstract = "Context There is controversy around the association between depressive symptoms and age in adult cancer patients. Objectives The aim of this study was to evaluate the following hypotheses: 1) cancer patients' depressive symptoms decrease with age, and 2) in individuals aged 65 years or older, depressive symptoms increase because of the effect of somatic symptoms. Methods We retrospectively analyzed a database of 356 cancer patients who were consecutively recruited in a previous multicenter cross-sectional study. Depressive symptoms were assessed by the Patient Health Questionnaire-9 (PHQ-9), and correlations with age and other factors were assessed by hierarchical multivariate regression analysis. Age was entered as the dependent variable in the first step, patient characteristics and cancer-related variables were entered in the second step, and somatic symptoms were entered in the last step. We analyzed this model for both the total sample and the subpopulation aged 65 years or older. Results In the total sample, the PHQ-9 score was significantly associated with lower age, fatigue, and shortness of breath (adjusted R2 14.2{\%}). In the subpopulation aged 65 years or older, no factor was associated with the PHQ-9 score (adjusted R2 7.3{\%}). Conclusion The finding that depressive symptoms in cancer patients decreased with age was concordant with our first hypothesis, but the second hypothesis was not supported. Younger cancer patients were vulnerable to depressive symptoms and should be monitored carefully. Further studies using more representative samples are needed to examine in detail the association between depressive symptoms and age in older cancer patients.",
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AU - Shimoda, Haruki

AU - Yoshiuchi, Kazuhiro

AU - Akechi, Tatsuo

AU - Uchida, Megumi

AU - Ogawa, Asao

AU - Fujisawa, Daisuke

AU - Inoue, Shinichirou

AU - Uchitomi, Yosuke

AU - Matsushima, Eisuke

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N2 - Context There is controversy around the association between depressive symptoms and age in adult cancer patients. Objectives The aim of this study was to evaluate the following hypotheses: 1) cancer patients' depressive symptoms decrease with age, and 2) in individuals aged 65 years or older, depressive symptoms increase because of the effect of somatic symptoms. Methods We retrospectively analyzed a database of 356 cancer patients who were consecutively recruited in a previous multicenter cross-sectional study. Depressive symptoms were assessed by the Patient Health Questionnaire-9 (PHQ-9), and correlations with age and other factors were assessed by hierarchical multivariate regression analysis. Age was entered as the dependent variable in the first step, patient characteristics and cancer-related variables were entered in the second step, and somatic symptoms were entered in the last step. We analyzed this model for both the total sample and the subpopulation aged 65 years or older. Results In the total sample, the PHQ-9 score was significantly associated with lower age, fatigue, and shortness of breath (adjusted R2 14.2%). In the subpopulation aged 65 years or older, no factor was associated with the PHQ-9 score (adjusted R2 7.3%). Conclusion The finding that depressive symptoms in cancer patients decreased with age was concordant with our first hypothesis, but the second hypothesis was not supported. Younger cancer patients were vulnerable to depressive symptoms and should be monitored carefully. Further studies using more representative samples are needed to examine in detail the association between depressive symptoms and age in older cancer patients.

AB - Context There is controversy around the association between depressive symptoms and age in adult cancer patients. Objectives The aim of this study was to evaluate the following hypotheses: 1) cancer patients' depressive symptoms decrease with age, and 2) in individuals aged 65 years or older, depressive symptoms increase because of the effect of somatic symptoms. Methods We retrospectively analyzed a database of 356 cancer patients who were consecutively recruited in a previous multicenter cross-sectional study. Depressive symptoms were assessed by the Patient Health Questionnaire-9 (PHQ-9), and correlations with age and other factors were assessed by hierarchical multivariate regression analysis. Age was entered as the dependent variable in the first step, patient characteristics and cancer-related variables were entered in the second step, and somatic symptoms were entered in the last step. We analyzed this model for both the total sample and the subpopulation aged 65 years or older. Results In the total sample, the PHQ-9 score was significantly associated with lower age, fatigue, and shortness of breath (adjusted R2 14.2%). In the subpopulation aged 65 years or older, no factor was associated with the PHQ-9 score (adjusted R2 7.3%). Conclusion The finding that depressive symptoms in cancer patients decreased with age was concordant with our first hypothesis, but the second hypothesis was not supported. Younger cancer patients were vulnerable to depressive symptoms and should be monitored carefully. Further studies using more representative samples are needed to examine in detail the association between depressive symptoms and age in older cancer patients.

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