The association between environmental factors and the development of Crohn's disease with focusing on passive smoking: A multicenter case-control study in Japan

Kyoko Kondo, Satoko Ohfuji, Kenji Watanabe, Hirokazu Yamagami, Wakaba Fukushima, Kazuya Ito, Yasuo Suzuki, Yoshio Hirota, Satoshi Motoya, Hirotake Sakuraba, Yo Ishiguro, Iwao Sasaki, Kenji Suzuki, Katsuyuki Fukuda, Masayuki Saruta, Masaru Shinozaki, Toshiaki Shimizu, Aoyagi You, Masakazu Nagahori, Mamoru WatanabeTakanori Kanai, Bunei Iizuka, Toshiaki Watanabe, Kiyonori Kobayashi, Reiko Kunisaki, Akira Sugita, Takashi Ishige, Soichiro Miura, Ryota Hokari, Hiroyuki Hanai, Hidemi Goto, Takafumi Ando, Satoshi Tanida, Takashi Joh, Tsutomu Mizoshita, Makoto Sasaki, Kazuya Kitamura, Satoru Umegae, Yoshihide Fujiyama, Akira Ando, Seiji Shimizu, Kazuhiko Yoshioka, Atsuo Kitano, Kazuki Aomatsu, Yuji Naito, Masaru Yoshida, Makoto Ooi, Takayuki Matsumoto, Ken Fukunaga, Masaki Iimuro, Hiroki Ikeuchi, Shunji Ishihara, Shinji Tanaka, Yoshitaka Ueno, Toshiyuki Matsui, Yutaka Yano, Hiroshi Yamasaki, Keichi Mitsuyama, Shojiro Yamamoto, Hirohito Tsubouchi, Kazuhito Sugimura, Takanori Tenjin

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Abstract

Background The number of patients with Crohn's disease (CD) in Japan has recently been increasing. We examined the association between environmental factors and the development of CD in Japanese focusing on passive smoking. Methods We conducted a multicenter case-control study and compared the environmental factors of 93 cases who were newly diagnosed with CD to the environmental factors of 132 controls (hospital-, age-, and sex-matched patients with other diseases). The odds ratio (OR) of each factor for the development of CD and the 95% confidence interval (CI) were calculated using a logistic regression model. The association between the details of passive smoking history and the development of CD was examined for those who had an active smoking history "no". Odds ratios of number of passively smoked cigarettes (per day), time of passive smoking (per day) and period of passive smoking (year) were calculated using "passive smoking 'No'" as a reference. Results History of appendicitis, family history of inflammatory bowel disease, and active smoking history were not significantly associated with the development of CD. Drinking history showed a decreased OR for the development of CD (0.39, 0.19-0.77). "Passive smoking Yes" showed significantly increased OR (2.49, 1.09-5.73). Regarding the association between passive smoking and the development of CD, the OR increased as the number of cigarettes per day, smoking time per day, and smoking duration increased, and there was a dose-response relationship (trend P = 0.024, 0.032, 0.038). Conclusions The association between environmental factors and the development of CD among Japanese was examined by case-control study. It was suggested that the passive smoking history may be associated to the development of CD.

Original languageEnglish
Article numbere0216429
JournalPloS one
Volume14
Issue number6
DOIs
Publication statusPublished - 2019 Jun 1

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kondo, K., Ohfuji, S., Watanabe, K., Yamagami, H., Fukushima, W., Ito, K., Suzuki, Y., Hirota, Y., Motoya, S., Sakuraba, H., Ishiguro, Y., Sasaki, I., Suzuki, K., Fukuda, K., Saruta, M., Shinozaki, M., Shimizu, T., You, A., Nagahori, M., ... Tenjin, T. (2019). The association between environmental factors and the development of Crohn's disease with focusing on passive smoking: A multicenter case-control study in Japan. PloS one, 14(6), [e0216429]. https://doi.org/10.1371/journal.pone.0216429