TY - JOUR
T1 - The association between gestational use of personal care products and neonatal urological abnormality at birth
T2 - The Japan Environment and Children's Study
AU - the Japan Environment and Children's Study (JECS) Group
AU - Nishihama, Yukiko
AU - Tatsuta, Nozomi
AU - Iwai-Shimada, Miyuki
AU - Nakai, Kunihiko
AU - Arima, Takahiro
AU - Fujiwara, Ikuma
AU - Yaegashi, Nobuo
AU - Takeuchi, Ayano
AU - Nakayama, Shoji F.
N1 - Funding Information:
The Japan Environment and Children’s Study was funded by the Ministry of the Environment, Japan .
Publisher Copyright:
© 2020 The Author(s)
PY - 2020/4
Y1 - 2020/4
N2 - Congenital anomalies of the kidney and urinary tract (CAKUT) include a broad group of birth defects. Exposure to endocrine disrupting chemicals (EDCs) is suspected to be one of the risk factors for CAKUT, and the use of personal care products (PCPs) is a source of EDC exposure. Therefore, this study aimed to investigate the relationship between CAKUT and the use of PCPs in a large birth cohort study. Data from 86,899 pregnant women included in the Japan Environment and Children's Study (JECS), an ongoing nationwide project, were analyzed. The prevalence of CAKUT in newborns was 0.25 % and almost 90 % of subjects used PCPs during mid-late pregnancy. No association was found between CAKUT and PCP use in a model adjusted for the following covariates: maternal age at delivery. The result was persistent after rigorous sensitivity analyses.
AB - Congenital anomalies of the kidney and urinary tract (CAKUT) include a broad group of birth defects. Exposure to endocrine disrupting chemicals (EDCs) is suspected to be one of the risk factors for CAKUT, and the use of personal care products (PCPs) is a source of EDC exposure. Therefore, this study aimed to investigate the relationship between CAKUT and the use of PCPs in a large birth cohort study. Data from 86,899 pregnant women included in the Japan Environment and Children's Study (JECS), an ongoing nationwide project, were analyzed. The prevalence of CAKUT in newborns was 0.25 % and almost 90 % of subjects used PCPs during mid-late pregnancy. No association was found between CAKUT and PCP use in a model adjusted for the following covariates: maternal age at delivery. The result was persistent after rigorous sensitivity analyses.
KW - CAKUT
KW - Congenital anomalies of the kidney and urinary tract
KW - Endocrine disrupting chemicals
KW - Personal care products
UR - http://www.scopus.com/inward/record.url?scp=85078422015&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078422015&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2020.01.005
DO - 10.1016/j.reprotox.2020.01.005
M3 - Article
C2 - 31978451
AN - SCOPUS:85078422015
SN - 0890-6238
VL - 93
SP - 83
EP - 88
JO - Reproductigve Toxicoloy
JF - Reproductigve Toxicoloy
ER -