The association between gestational use of personal care products and neonatal urological abnormality at birth: The Japan Environment and Children's Study

the Japan Environment and Children's Study (JECS) Group

Research output: Contribution to journalArticle

Abstract

Congenital anomalies of the kidney and urinary tract (CAKUT) include a broad group of birth defects. Exposure to endocrine disrupting chemicals (EDCs) is suspected to be one of the risk factors for CAKUT, and the use of personal care products (PCPs) is a source of EDC exposure. Therefore, this study aimed to investigate the relationship between CAKUT and the use of PCPs in a large birth cohort study. Data from 86,899 pregnant women included in the Japan Environment and Children's Study (JECS), an ongoing nationwide project, were analyzed. The prevalence of CAKUT in newborns was 0.25 % and almost 90 % of subjects used PCPs during mid-late pregnancy. No association was found between CAKUT and PCP use in a model adjusted for the following covariates: maternal age at delivery. The result was persistent after rigorous sensitivity analyses.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalReproductive Toxicology
Volume93
DOIs
Publication statusPublished - 2020 Apr

    Fingerprint

Keywords

  • CAKUT
  • Congenital anomalies of the kidney and urinary tract
  • Endocrine disrupting chemicals
  • Personal care products

ASJC Scopus subject areas

  • Toxicology

Cite this