The association between high-density lipoprotein cholesterol level and cholesteryl ester transfer protein TaqIB gene polymorphism is influenced by alcohol drinking in a population-based sample

Yasuyuki Tsujita, Yasuyuki Nakamura, Qishan Zhang, Shinji Tamaki, Akihiko Nozaki, Kenji Amamoto, Takashi Kadowaki, Yoshikuni Kita, Tomonori Okamura, Minoru Horie, Hirotsugu Ueshima

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22 Citations (Scopus)

Abstract

Cholesteryl ester transfer protein (CETP) is a key enzyme in high-density lipoprotein (HDL) cholesterol metabolism. We studied the association between CETP TaqIB polymorphism and the HDL cholesterol levels considering environmental factors in a population-based sample consisting of 1729 participants who did not use lipid-lowering agents (659 men and 1070 women). The CETP TaqIB genotypes were determined by PCR-RFLP analysis. The serum HDL cholesterol levels of female participants with the B2B2 genotype were significantly higher than those with other genotypes (p < 0.001). Multiple regression analysis with covariates such as age, waist to hip (W/H) ratio, alcohol drinking, current smoking, non-HDL cholesterol, and logarithm of triglyceride revealed that the CETP TaqIB genotype was an independent determinant of HDL cholesterol levels in men (p = 0.049) and women (p < 0.001). Subgroup analysis revealed that an interaction was observed between the CETP TaqIB polymorphism and alcohol consumption in the regulation of HDL cholesterol levels in men (p = 0.049) and women (p = 0.022). No interactions were observed between the CETP TaqIB polymorphism and current smoking status, body mass index, or W/H ratio in the regulation of HDL cholesterol levels. The association between the CETP TaqIB polymorphism and HDL cholesterol levels was more evident in alcohol consumers than in non-drinkers.

Original languageEnglish
Pages (from-to)199-205
Number of pages7
JournalAtherosclerosis
Volume191
Issue number1
DOIs
Publication statusPublished - 2007 Mar 1
Externally publishedYes

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Keywords

  • Alcohol
  • Cholesteryl ester transfer protein
  • Gene-environmental interactions
  • High-density lipoprotein
  • Polymorphism
  • Population-based sample

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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