The association between serum uric acid and renal damage in a community-based population: The Takahata study

Kazuko Suzuki, Tsuneo Konta, Kosuke Kudo, Hiroko Sato, Ami Ikeda, Kazunobu Ichikawa, Yoshiyuki Ueno, Takeo Kato, Takamasa Kayama, Isao Kubota

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Hyperuricemia is a risk factor for end-stage renal disease. This study examined the association between serum uric acid and renal damage in a community-based population. Methods: In this study 3126 subjects without renal insufficiency were recruited at baseline and were followed for one year. The urinary albumin-creatinine ratio (UACR) and β2-microglobulin- creatinine ratio (UBCR) in morning spot urine samples were used as indices of either glomerular (UACR) or tubular (UBCR) damage. Results: The mean value of serum uric acid (mg/dL) was 5.8 ± 1.3 (SD) in men and 4.5 ± 1.1 in women. In cross-sectional analysis the increased serum uric acid levels were accompanied by higher UACR values in both men and women (P < 0.01). In contrast, UBCR values were reduced when uric acid levels increased in both men and women (P < 0.01). Multivariate analysis revealed that albuminuria (UACR ≥ 30 mg/g) was significantly associated with increased uric acid (≥7 mg/dL for men, ≥6 mg/dL for women). High UBCR (≥300 μg/g) was negatively associated with uric acid in men, but not in women, after adjustment for possible confounders. In longitudinal analysis in 1388 subjects multiple linear regression analysis showed that uric acid at baseline was an independent factor for one-year increase of UACR [coefficient 4.80 (95 % confidence interval 0.40-9.33) (mg/g) per 1 mg/dL increase in uric acid, P = 0.033]. Conclusion: This study showed that serum uric acid concentration was positively associated with UACR, suggesting that uric acid may be related to glomerular damage in a community-based population.

Original languageEnglish
Pages (from-to)541-548
Number of pages8
JournalClinical and Experimental Nephrology
Volume17
Issue number4
DOIs
Publication statusPublished - 2013 Aug
Externally publishedYes

Fingerprint

Uric Acid
Creatinine
Kidney
Albumins
Serum
Population
Hyperuricemia
Albuminuria
Chronic Kidney Failure
Renal Insufficiency
Linear Models
Multivariate Analysis
Cross-Sectional Studies
Regression Analysis
Urine
Confidence Intervals

Keywords

  • Albuminuria
  • Tubular damage
  • Uric acid

ASJC Scopus subject areas

  • Nephrology
  • Physiology
  • Physiology (medical)

Cite this

The association between serum uric acid and renal damage in a community-based population : The Takahata study. / Suzuki, Kazuko; Konta, Tsuneo; Kudo, Kosuke; Sato, Hiroko; Ikeda, Ami; Ichikawa, Kazunobu; Ueno, Yoshiyuki; Kato, Takeo; Kayama, Takamasa; Kubota, Isao.

In: Clinical and Experimental Nephrology, Vol. 17, No. 4, 08.2013, p. 541-548.

Research output: Contribution to journalArticle

Suzuki, K, Konta, T, Kudo, K, Sato, H, Ikeda, A, Ichikawa, K, Ueno, Y, Kato, T, Kayama, T & Kubota, I 2013, 'The association between serum uric acid and renal damage in a community-based population: The Takahata study', Clinical and Experimental Nephrology, vol. 17, no. 4, pp. 541-548. https://doi.org/10.1007/s10157-012-0743-y
Suzuki, Kazuko ; Konta, Tsuneo ; Kudo, Kosuke ; Sato, Hiroko ; Ikeda, Ami ; Ichikawa, Kazunobu ; Ueno, Yoshiyuki ; Kato, Takeo ; Kayama, Takamasa ; Kubota, Isao. / The association between serum uric acid and renal damage in a community-based population : The Takahata study. In: Clinical and Experimental Nephrology. 2013 ; Vol. 17, No. 4. pp. 541-548.
@article{39b81a52139641eba8044de28388aafc,
title = "The association between serum uric acid and renal damage in a community-based population: The Takahata study",
abstract = "Background: Hyperuricemia is a risk factor for end-stage renal disease. This study examined the association between serum uric acid and renal damage in a community-based population. Methods: In this study 3126 subjects without renal insufficiency were recruited at baseline and were followed for one year. The urinary albumin-creatinine ratio (UACR) and β2-microglobulin- creatinine ratio (UBCR) in morning spot urine samples were used as indices of either glomerular (UACR) or tubular (UBCR) damage. Results: The mean value of serum uric acid (mg/dL) was 5.8 ± 1.3 (SD) in men and 4.5 ± 1.1 in women. In cross-sectional analysis the increased serum uric acid levels were accompanied by higher UACR values in both men and women (P < 0.01). In contrast, UBCR values were reduced when uric acid levels increased in both men and women (P < 0.01). Multivariate analysis revealed that albuminuria (UACR ≥ 30 mg/g) was significantly associated with increased uric acid (≥7 mg/dL for men, ≥6 mg/dL for women). High UBCR (≥300 μg/g) was negatively associated with uric acid in men, but not in women, after adjustment for possible confounders. In longitudinal analysis in 1388 subjects multiple linear regression analysis showed that uric acid at baseline was an independent factor for one-year increase of UACR [coefficient 4.80 (95 {\%} confidence interval 0.40-9.33) (mg/g) per 1 mg/dL increase in uric acid, P = 0.033]. Conclusion: This study showed that serum uric acid concentration was positively associated with UACR, suggesting that uric acid may be related to glomerular damage in a community-based population.",
keywords = "Albuminuria, Tubular damage, Uric acid",
author = "Kazuko Suzuki and Tsuneo Konta and Kosuke Kudo and Hiroko Sato and Ami Ikeda and Kazunobu Ichikawa and Yoshiyuki Ueno and Takeo Kato and Takamasa Kayama and Isao Kubota",
year = "2013",
month = "8",
doi = "10.1007/s10157-012-0743-y",
language = "English",
volume = "17",
pages = "541--548",
journal = "Clinical and Experimental Nephrology",
issn = "1342-1751",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - The association between serum uric acid and renal damage in a community-based population

T2 - The Takahata study

AU - Suzuki, Kazuko

AU - Konta, Tsuneo

AU - Kudo, Kosuke

AU - Sato, Hiroko

AU - Ikeda, Ami

AU - Ichikawa, Kazunobu

AU - Ueno, Yoshiyuki

AU - Kato, Takeo

AU - Kayama, Takamasa

AU - Kubota, Isao

PY - 2013/8

Y1 - 2013/8

N2 - Background: Hyperuricemia is a risk factor for end-stage renal disease. This study examined the association between serum uric acid and renal damage in a community-based population. Methods: In this study 3126 subjects without renal insufficiency were recruited at baseline and were followed for one year. The urinary albumin-creatinine ratio (UACR) and β2-microglobulin- creatinine ratio (UBCR) in morning spot urine samples were used as indices of either glomerular (UACR) or tubular (UBCR) damage. Results: The mean value of serum uric acid (mg/dL) was 5.8 ± 1.3 (SD) in men and 4.5 ± 1.1 in women. In cross-sectional analysis the increased serum uric acid levels were accompanied by higher UACR values in both men and women (P < 0.01). In contrast, UBCR values were reduced when uric acid levels increased in both men and women (P < 0.01). Multivariate analysis revealed that albuminuria (UACR ≥ 30 mg/g) was significantly associated with increased uric acid (≥7 mg/dL for men, ≥6 mg/dL for women). High UBCR (≥300 μg/g) was negatively associated with uric acid in men, but not in women, after adjustment for possible confounders. In longitudinal analysis in 1388 subjects multiple linear regression analysis showed that uric acid at baseline was an independent factor for one-year increase of UACR [coefficient 4.80 (95 % confidence interval 0.40-9.33) (mg/g) per 1 mg/dL increase in uric acid, P = 0.033]. Conclusion: This study showed that serum uric acid concentration was positively associated with UACR, suggesting that uric acid may be related to glomerular damage in a community-based population.

AB - Background: Hyperuricemia is a risk factor for end-stage renal disease. This study examined the association between serum uric acid and renal damage in a community-based population. Methods: In this study 3126 subjects without renal insufficiency were recruited at baseline and were followed for one year. The urinary albumin-creatinine ratio (UACR) and β2-microglobulin- creatinine ratio (UBCR) in morning spot urine samples were used as indices of either glomerular (UACR) or tubular (UBCR) damage. Results: The mean value of serum uric acid (mg/dL) was 5.8 ± 1.3 (SD) in men and 4.5 ± 1.1 in women. In cross-sectional analysis the increased serum uric acid levels were accompanied by higher UACR values in both men and women (P < 0.01). In contrast, UBCR values were reduced when uric acid levels increased in both men and women (P < 0.01). Multivariate analysis revealed that albuminuria (UACR ≥ 30 mg/g) was significantly associated with increased uric acid (≥7 mg/dL for men, ≥6 mg/dL for women). High UBCR (≥300 μg/g) was negatively associated with uric acid in men, but not in women, after adjustment for possible confounders. In longitudinal analysis in 1388 subjects multiple linear regression analysis showed that uric acid at baseline was an independent factor for one-year increase of UACR [coefficient 4.80 (95 % confidence interval 0.40-9.33) (mg/g) per 1 mg/dL increase in uric acid, P = 0.033]. Conclusion: This study showed that serum uric acid concentration was positively associated with UACR, suggesting that uric acid may be related to glomerular damage in a community-based population.

KW - Albuminuria

KW - Tubular damage

KW - Uric acid

UR - http://www.scopus.com/inward/record.url?scp=84883309105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883309105&partnerID=8YFLogxK

U2 - 10.1007/s10157-012-0743-y

DO - 10.1007/s10157-012-0743-y

M3 - Article

C2 - 23183785

AN - SCOPUS:84883309105

VL - 17

SP - 541

EP - 548

JO - Clinical and Experimental Nephrology

JF - Clinical and Experimental Nephrology

SN - 1342-1751

IS - 4

ER -