The cerebral hemodynamic response to phonetic changes of speech in preterm and term infants

The impact of postmenstrual age

Takeshi Arimitsu, Yasuyo Minagawa, Tatsuhiko Yagihashi, Mariko O. Uchida, Atsuko Matsuzaki, Kazushige Ikeda, Takao Takahashi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Higher brain dysfunction, such as language delay, is a major concern among preterm infants. Cerebral substrates of cognitive development in preterm infants remain elusive, partly because of limited methods. The present study focuses on hemodynamic response patterns for brain function by using near-infrared spectroscopy. Specifically, the study investigates gestational differences in the hemodynamic response pattern evoked in response to phonetic changes of speech and cerebral hemispheric specialization of the auditory area in preterm infants (n = 60) and term infants (n = 20). Eighty neonates born between 26 and 41 weeks of gestational age (GA) were tested from 33 to 41 weeks of postmenstrual age (PMA). We analyzed the hemodynamic response pattern to phonemic and prosodic contrasts for multiple channels on temporal regions and the laterality index of the auditory area. Preterm infants younger than 39 weeks of PMA showed significantly atypical hemodynamic patterns, with an inverted response shape. Partial correlation analysis of the typicality score of hemodynamic response revealed a significant positive correlation with PMA. The laterality index of preterm infants from 39 weeks of PMA demonstrated a tendency rightward dominance for prosodic changes similar to term infants. We provide new evidence that alterations in hemodynamic regulation and the functional system for phonemic and prosodic processing in preterm infants catch up by their projected due dates.

Original languageEnglish
Pages (from-to)599-606
Number of pages8
JournalNeuroImage: Clinical
Volume19
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Phonetics
Premature Infants
Hemodynamics
Auditory Cortex
Cerebral Dominance
Language Development Disorders
Near-Infrared Spectroscopy
Temporal Lobe
Gestational Age
Newborn Infant
Brain

Keywords

  • Laterality
  • Near-infrared spectroscopy
  • Preterm infants
  • Speech perception

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

The cerebral hemodynamic response to phonetic changes of speech in preterm and term infants : The impact of postmenstrual age. / Arimitsu, Takeshi; Minagawa, Yasuyo; Yagihashi, Tatsuhiko; O. Uchida, Mariko; Matsuzaki, Atsuko; Ikeda, Kazushige; Takahashi, Takao.

In: NeuroImage: Clinical, Vol. 19, 01.01.2018, p. 599-606.

Research output: Contribution to journalArticle

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