TY - JOUR
T1 - The characteristics of the patients with radiologically severe cervical ossification of the posterior longitudinal ligament of the spine
T2 - A CT-based multicenter cross-sectional study
AU - Mori, Kanji
AU - Yoshii, Toshitaka
AU - Hirai, Takashi
AU - Nagoshi, Narihito
AU - Takeuchi, Kazuhiro
AU - Ushio, Shuta
AU - Iwanami, Akio
AU - Yamada, Tsuyoshi
AU - Seki, Shoji
AU - Tsuji, Takashi
AU - Fujiyoshi, Kanehiro
AU - Furukawa, Mitsuru
AU - Nishimura, Soraya
AU - Wada, Kanichiro
AU - Furuya, Takeo
AU - Matsuyama, Yukihiro
AU - Hasegawa, Tomohiko
AU - Takeshita, Katsushi
AU - Kimura, Atsushi
AU - Abematsu, Masahiko
AU - Haro, Hirotaka
AU - Ohba, Tetsuro
AU - Watanabe, Masahiko
AU - Katoh, Hiroyuki
AU - Watanabe, Kei
AU - Ozawa, Hiroshi
AU - Kanno, Haruo
AU - Imagama, Shiro
AU - Ando, Kei
AU - Fujibayashi, Shunsuke
AU - Koda, Masao
AU - Yamazaki, Masashi
AU - Matsumoto, Morio
AU - Nakamura, Masaya
AU - Okawa, Atsushi
AU - Kawaguchi, Yoshiharu
N1 - Funding Information:
This work was supported by Japanese Health and Labour Science Research Grants (# 201610008B ). No other financial associations that may be relevant or seen as relevant to the submitted manuscript.
Publisher Copyright:
© 2019 The Japanese Orthopaedic Association
PY - 2020/9
Y1 - 2020/9
N2 - Background: Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by heterotopic bone formation in the posterior longitudinal ligament of the spine. We know that the size and distribution of the ossified lesions in patients with OPLL are different in each case. However, the characteristics of the patients with radiologically severe cervical OPLL remain unknown. Methods: The participants of our study were symptomatic patients with cervical OPLL who were diagnosed by standard radiographs of the cervical spine. Whole-spine CT data and demographic data such as age and sex were obtained from 20 institutions belonging to the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament. According to the number of the levels involved by OPLL, we stratified the patients into two subgroups: severe group (S-group) and non-severe group (NS-group) to delineate the characteristics of radiologically severe patients with cervical OPLL. We also evaluated the most compressed level and the degree of occupying ratio of cervical spinal canal by OPLL at the most compressed level. Results: A total of 234 patients with a mean age of 65 years were recruited. The S-group consisted of 48 patients (21%, 12 females and 36 males) and the NS-group consisted of 92 patients (79%, 22 females and 70 males). The mean age of males in the S-group (68 years old) was significantly higher than that of males in the NS-group (64 years old); however there was no significant difference in the mean age in females between the S-group (69 years old) and the NS-group (66 years old). No significant difference of body mass index, ossification of the nuchal ligament-positivity and presence of diabetes mellitus were found between the S- and the NS-group. Conclusions: It is likely that the manner of extension of cervical OPLL is different between male and female patients.
AB - Background: Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by heterotopic bone formation in the posterior longitudinal ligament of the spine. We know that the size and distribution of the ossified lesions in patients with OPLL are different in each case. However, the characteristics of the patients with radiologically severe cervical OPLL remain unknown. Methods: The participants of our study were symptomatic patients with cervical OPLL who were diagnosed by standard radiographs of the cervical spine. Whole-spine CT data and demographic data such as age and sex were obtained from 20 institutions belonging to the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament. According to the number of the levels involved by OPLL, we stratified the patients into two subgroups: severe group (S-group) and non-severe group (NS-group) to delineate the characteristics of radiologically severe patients with cervical OPLL. We also evaluated the most compressed level and the degree of occupying ratio of cervical spinal canal by OPLL at the most compressed level. Results: A total of 234 patients with a mean age of 65 years were recruited. The S-group consisted of 48 patients (21%, 12 females and 36 males) and the NS-group consisted of 92 patients (79%, 22 females and 70 males). The mean age of males in the S-group (68 years old) was significantly higher than that of males in the NS-group (64 years old); however there was no significant difference in the mean age in females between the S-group (69 years old) and the NS-group (66 years old). No significant difference of body mass index, ossification of the nuchal ligament-positivity and presence of diabetes mellitus were found between the S- and the NS-group. Conclusions: It is likely that the manner of extension of cervical OPLL is different between male and female patients.
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U2 - 10.1016/j.jos.2019.09.018
DO - 10.1016/j.jos.2019.09.018
M3 - Article
C2 - 31672380
AN - SCOPUS:85074404315
SN - 0949-2658
VL - 25
SP - 746
EP - 750
JO - Journal of Orthopaedic Science
JF - Journal of Orthopaedic Science
IS - 5
ER -
