The chemosensitivity of nodal metastases in recurrent epithelial ovarian cancer

Fumio Kataoka, H. Tsuda, Hiroyuki Nomura, Tatsuyuki Chiyoda, Eiichirou Tominaga, A. Suzuki, N. Susumu, Daisuke Aoki

Research output: Contribution to journalArticle

Abstract

Purpose: In this study, we compared second-line chemotherapy effects of nodal metastases with other metastases sites. Methods: The medical records of 44 women with recurrent ovarian cancer who received second-line chemotherapy were retrospectively reviewed. Results: Median age at the time of second-line chemotherapy was 55 years (range: 31-74). Recurrent sites were as follows: 29 patients had a solitary site (abdominal cavity: 8; lymph node: 3; pelvic cavity: 10; liver: 4; lung: 4) and 15 patients had multiple sites In total, the response rate was 30% (CR: 8, PR: 5). The response rate in sensitive cases was higher than in refractory/resistant cases (50% vs 5% p = 0.002). However, age, chemotherapy regimen, histologic type and number of diseases were not related with chemotherapy effect. In all diseases, response rate tended to be higher in lymph node disease than in the others (44% vs 27%). In both sensitive and refractory/resistant cases, response rate tended to be higher in lymph node disease. Conclusion: The response rate for lymph node diseases tended to be relatively high. Further study analyzing survival will be required to conclude the chemotherapy effect.

Original languageEnglish
Pages (from-to)160-163
Number of pages4
JournalEuropean Journal of Gynaecological Oncology
Volume32
Issue number2
Publication statusPublished - 2011

Fingerprint

Neoplasm Metastasis
Drug Therapy
Lymph Nodes
Abdominal Cavity
Ovarian Neoplasms
Medical Records
Ovarian epithelial cancer
Lung
Survival
Liver

Keywords

  • Lymph node
  • Recurrence
  • Recurrent site
  • Second-line chemotherapy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

The chemosensitivity of nodal metastases in recurrent epithelial ovarian cancer. / Kataoka, Fumio; Tsuda, H.; Nomura, Hiroyuki; Chiyoda, Tatsuyuki; Tominaga, Eiichirou; Suzuki, A.; Susumu, N.; Aoki, Daisuke.

In: European Journal of Gynaecological Oncology, Vol. 32, No. 2, 2011, p. 160-163.

Research output: Contribution to journalArticle

@article{87627b37eb1947efa4eb35a1c1eec631,
title = "The chemosensitivity of nodal metastases in recurrent epithelial ovarian cancer",
abstract = "Purpose: In this study, we compared second-line chemotherapy effects of nodal metastases with other metastases sites. Methods: The medical records of 44 women with recurrent ovarian cancer who received second-line chemotherapy were retrospectively reviewed. Results: Median age at the time of second-line chemotherapy was 55 years (range: 31-74). Recurrent sites were as follows: 29 patients had a solitary site (abdominal cavity: 8; lymph node: 3; pelvic cavity: 10; liver: 4; lung: 4) and 15 patients had multiple sites In total, the response rate was 30{\%} (CR: 8, PR: 5). The response rate in sensitive cases was higher than in refractory/resistant cases (50{\%} vs 5{\%} p = 0.002). However, age, chemotherapy regimen, histologic type and number of diseases were not related with chemotherapy effect. In all diseases, response rate tended to be higher in lymph node disease than in the others (44{\%} vs 27{\%}). In both sensitive and refractory/resistant cases, response rate tended to be higher in lymph node disease. Conclusion: The response rate for lymph node diseases tended to be relatively high. Further study analyzing survival will be required to conclude the chemotherapy effect.",
keywords = "Lymph node, Recurrence, Recurrent site, Second-line chemotherapy",
author = "Fumio Kataoka and H. Tsuda and Hiroyuki Nomura and Tatsuyuki Chiyoda and Eiichirou Tominaga and A. Suzuki and N. Susumu and Daisuke Aoki",
year = "2011",
language = "English",
volume = "32",
pages = "160--163",
journal = "European Journal of Gynaecological Oncology",
issn = "0392-2936",
publisher = "S.O.G. CANADA Inc.",
number = "2",

}

TY - JOUR

T1 - The chemosensitivity of nodal metastases in recurrent epithelial ovarian cancer

AU - Kataoka, Fumio

AU - Tsuda, H.

AU - Nomura, Hiroyuki

AU - Chiyoda, Tatsuyuki

AU - Tominaga, Eiichirou

AU - Suzuki, A.

AU - Susumu, N.

AU - Aoki, Daisuke

PY - 2011

Y1 - 2011

N2 - Purpose: In this study, we compared second-line chemotherapy effects of nodal metastases with other metastases sites. Methods: The medical records of 44 women with recurrent ovarian cancer who received second-line chemotherapy were retrospectively reviewed. Results: Median age at the time of second-line chemotherapy was 55 years (range: 31-74). Recurrent sites were as follows: 29 patients had a solitary site (abdominal cavity: 8; lymph node: 3; pelvic cavity: 10; liver: 4; lung: 4) and 15 patients had multiple sites In total, the response rate was 30% (CR: 8, PR: 5). The response rate in sensitive cases was higher than in refractory/resistant cases (50% vs 5% p = 0.002). However, age, chemotherapy regimen, histologic type and number of diseases were not related with chemotherapy effect. In all diseases, response rate tended to be higher in lymph node disease than in the others (44% vs 27%). In both sensitive and refractory/resistant cases, response rate tended to be higher in lymph node disease. Conclusion: The response rate for lymph node diseases tended to be relatively high. Further study analyzing survival will be required to conclude the chemotherapy effect.

AB - Purpose: In this study, we compared second-line chemotherapy effects of nodal metastases with other metastases sites. Methods: The medical records of 44 women with recurrent ovarian cancer who received second-line chemotherapy were retrospectively reviewed. Results: Median age at the time of second-line chemotherapy was 55 years (range: 31-74). Recurrent sites were as follows: 29 patients had a solitary site (abdominal cavity: 8; lymph node: 3; pelvic cavity: 10; liver: 4; lung: 4) and 15 patients had multiple sites In total, the response rate was 30% (CR: 8, PR: 5). The response rate in sensitive cases was higher than in refractory/resistant cases (50% vs 5% p = 0.002). However, age, chemotherapy regimen, histologic type and number of diseases were not related with chemotherapy effect. In all diseases, response rate tended to be higher in lymph node disease than in the others (44% vs 27%). In both sensitive and refractory/resistant cases, response rate tended to be higher in lymph node disease. Conclusion: The response rate for lymph node diseases tended to be relatively high. Further study analyzing survival will be required to conclude the chemotherapy effect.

KW - Lymph node

KW - Recurrence

KW - Recurrent site

KW - Second-line chemotherapy

UR - http://www.scopus.com/inward/record.url?scp=79955680556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955680556&partnerID=8YFLogxK

M3 - Article

C2 - 21614904

AN - SCOPUS:79955680556

VL - 32

SP - 160

EP - 163

JO - European Journal of Gynaecological Oncology

JF - European Journal of Gynaecological Oncology

SN - 0392-2936

IS - 2

ER -