The chemosensitivity of nodal metastases in recurrent epithelial ovarian cancer

F. Kataoka, H. Tsuda, H. Nomura, T. Chiyoda, E. Tominaga, A. Suzuki, N. Susumu, D. Aoki

Research output: Contribution to journalArticle

Abstract

Purpose: In this study, we compared second-line chemotherapy effects of nodal metastases with other metastases sites. Methods: The medical records of 44 women with recurrent ovarian cancer who received second-line chemotherapy were retrospectively reviewed. Results: Median age at the time of second-line chemotherapy was 55 years (range: 31-74). Recurrent sites were as follows: 29 patients had a solitary site (abdominal cavity: 8; lymph node: 3; pelvic cavity: 10; liver: 4; lung: 4) and 15 patients had multiple sites In total, the response rate was 30% (CR: 8, PR: 5). The response rate in sensitive cases was higher than in refractory/resistant cases (50% vs 5% p = 0.002). However, age, chemotherapy regimen, histologic type and number of diseases were not related with chemotherapy effect. In all diseases, response rate tended to be higher in lymph node disease than in the others (44% vs 27%). In both sensitive and refractory/resistant cases, response rate tended to be higher in lymph node disease. Conclusion: The response rate for lymph node diseases tended to be relatively high. Further study analyzing survival will be required to conclude the chemotherapy effect.

Original languageEnglish
Pages (from-to)160-163
Number of pages4
JournalEuropean Journal of Gynaecological Oncology
Volume32
Issue number2
Publication statusPublished - 2011 May 11

Keywords

  • Lymph node
  • Recurrence
  • Recurrent site
  • Second-line chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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