The chiral diamine mediated asymmetric Baylis-Hillman reaction

Yujiro Hayashi, Tomohiro Tamura, Mitsuru Shoji

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49 Citations (Scopus)

Abstract

A chiral diamine, easily prepared from proline, is an effective, asymmetric organic catalyst for the Baylis-Hillman reaction of aldehydes and methyl vinyl ketone, affording adducts with enantio-selectivities up to 75%.

Original languageEnglish
Pages (from-to)1106-1110
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume346
Issue number9-10
DOIs
Publication statusPublished - 2004 Aug 1

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Keywords

  • Asymmetric synthesis
  • Baylis-Hillman reaction
  • Diamines
  • Enones
  • Lewis base catalysts
  • Organic catalysis

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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