The chiral diamine mediated asymmetric Baylis-Hillman reaction

Yujiro Hayashi, Tomohiro Tamura, Mitsuru Shoji

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

A chiral diamine, easily prepared from proline, is an effective, asymmetric organic catalyst for the Baylis-Hillman reaction of aldehydes and methyl vinyl ketone, affording adducts with enantio-selectivities up to 75%.

Original languageEnglish
Pages (from-to)1106-1110
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume346
Issue number9-10
DOIs
Publication statusPublished - 2004 Aug
Externally publishedYes

Fingerprint

Diamines
Enantioselectivity
Aldehydes
Ketones
Proline
Catalysts
3-buten-2-one

Keywords

  • Asymmetric synthesis
  • Baylis-Hillman reaction
  • Diamines
  • Enones
  • Lewis base catalysts
  • Organic catalysis

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Organic Chemistry
  • Catalysis

Cite this

The chiral diamine mediated asymmetric Baylis-Hillman reaction. / Hayashi, Yujiro; Tamura, Tomohiro; Shoji, Mitsuru.

In: Advanced Synthesis and Catalysis, Vol. 346, No. 9-10, 08.2004, p. 1106-1110.

Research output: Contribution to journalArticle

Hayashi, Yujiro ; Tamura, Tomohiro ; Shoji, Mitsuru. / The chiral diamine mediated asymmetric Baylis-Hillman reaction. In: Advanced Synthesis and Catalysis. 2004 ; Vol. 346, No. 9-10. pp. 1106-1110.
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