The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma: An analysis of 147 cases

Yukihiro Nakanishi, Atsushi Ochiai, Kimio Yoshimura, Hoichi Kato, Tadakazu Shimoda, Hajime Yamaguchi, Yuji Tachimori, Hiroshi Watanabe, Setsuo Hirohashi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

BACKGROUND. Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS. For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS. Ninety-two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12%) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35%) had 6-10 and 78 (53%) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas (P < 0.01). CONCLUSIONS. Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract.

Original languageEnglish
Pages (from-to)1454-1459
Number of pages6
JournalCancer
Volume82
Issue number8
DOIs
Publication statusPublished - 1998 Apr 15
Externally publishedYes

Fingerprint

Mucous Membrane
Carcinoma
Neoplasms
Incidence
Tobacco Use
Alcohol Drinking
Alcohols
Lugol's solution
Staining and Labeling
Light

Keywords

  • Alcohol
  • Dysplasia
  • Esophageal carcinoma
  • Head and neck cancer
  • Lugol's iodine-unstained area
  • Multicentricity
  • Tobacco

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma : An analysis of 147 cases. / Nakanishi, Yukihiro; Ochiai, Atsushi; Yoshimura, Kimio; Kato, Hoichi; Shimoda, Tadakazu; Yamaguchi, Hajime; Tachimori, Yuji; Watanabe, Hiroshi; Hirohashi, Setsuo.

In: Cancer, Vol. 82, No. 8, 15.04.1998, p. 1454-1459.

Research output: Contribution to journalArticle

Nakanishi, Yukihiro ; Ochiai, Atsushi ; Yoshimura, Kimio ; Kato, Hoichi ; Shimoda, Tadakazu ; Yamaguchi, Hajime ; Tachimori, Yuji ; Watanabe, Hiroshi ; Hirohashi, Setsuo. / The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma : An analysis of 147 cases. In: Cancer. 1998 ; Vol. 82, No. 8. pp. 1454-1459.
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abstract = "BACKGROUND. Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS. For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS. Ninety-two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12{\%}) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35{\%}) had 6-10 and 78 (53{\%}) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas (P < 0.01). CONCLUSIONS. Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract.",
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AU - Yoshimura, Kimio

AU - Kato, Hoichi

AU - Shimoda, Tadakazu

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N2 - BACKGROUND. Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS. For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS. Ninety-two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12%) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35%) had 6-10 and 78 (53%) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas (P < 0.01). CONCLUSIONS. Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract.

AB - BACKGROUND. Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS. For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS. Ninety-two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12%) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35%) had 6-10 and 78 (53%) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas (P < 0.01). CONCLUSIONS. Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract.

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