Abstract
BACKGROUND. Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS. For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS. Ninety-two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12%) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35%) had 6-10 and 78 (53%) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas (P < 0.01). CONCLUSIONS. Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract.
| Original language | English |
|---|---|
| Pages (from-to) | 1454-1459 |
| Number of pages | 6 |
| Journal | Cancer |
| Volume | 82 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1998 Apr 15 |
| Externally published | Yes |
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Keywords
- Alcohol
- Dysplasia
- Esophageal carcinoma
- Head and neck cancer
- Lugol's iodine-unstained area
- Multicentricity
- Tobacco
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma : An analysis of 147 cases. / Nakanishi, Yukihiro; Ochiai, Atsushi; Yoshimura, Kimio; Kato, Hoichi; Shimoda, Tadakazu; Yamaguchi, Hajime; Tachimori, Yuji; Watanabe, Hiroshi; Hirohashi, Setsuo.
In: Cancer, Vol. 82, No. 8, 15.04.1998, p. 1454-1459.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma
T2 - An analysis of 147 cases
AU - Nakanishi, Yukihiro
AU - Ochiai, Atsushi
AU - Yoshimura, Kimio
AU - Kato, Hoichi
AU - Shimoda, Tadakazu
AU - Yamaguchi, Hajime
AU - Tachimori, Yuji
AU - Watanabe, Hiroshi
AU - Hirohashi, Setsuo
PY - 1998/4/15
Y1 - 1998/4/15
N2 - BACKGROUND. Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS. For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS. Ninety-two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12%) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35%) had 6-10 and 78 (53%) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas (P < 0.01). CONCLUSIONS. Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract.
AB - BACKGROUND. Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS. For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS. Ninety-two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12%) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35%) had 6-10 and 78 (53%) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas (P < 0.01). CONCLUSIONS. Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract.
KW - Alcohol
KW - Dysplasia
KW - Esophageal carcinoma
KW - Head and neck cancer
KW - Lugol's iodine-unstained area
KW - Multicentricity
KW - Tobacco
UR - http://www.scopus.com/inward/record.url?scp=0032523179&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032523179&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0142(19980415)82:8<1454::AID-CNCR4>3.0.CO;2-9
DO - 10.1002/(SICI)1097-0142(19980415)82:8<1454::AID-CNCR4>3.0.CO;2-9
M3 - Article
C2 - 9554520
AN - SCOPUS:0032523179
VL - 82
SP - 1454
EP - 1459
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 8
ER -