The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus

Hitoshi Nakashima, Hisako Inoue, Mitsuteru Akahoshi, Yosuke Tanaka, Kunihiro Yamaoka, Eiichi Ogami, Shuuji Nagano, Yojiro Arinobu, Hiroaki Niiro, Takeshi Otsuka, Yoshiyuki Niho

Research output: Contribution to journal › Article

53 Citations (Scopus)

Abstract

Genetic factors seem to play a significant role in susceptibility to systemic lupus erythematosus (SLE). We previously described the amino acid polymorphism (Val14Met) within the IFN-γ receptor 1 (IFN-γR1), and that the frequency of the Met14 allele in SLE patients was significantly higher than that of the healthy control population. We also found an amino acid polymorphism (Gln64Arg) within IFN-γ receptor 2 (IFN-γR2). Since the IFN-γ receptor is a complex consisting of IFN-γR1 and IFN-γR2, we searched for the particular combination of two kinds of amino acid polymorphisms found within the IFN-γ receptor which plays a prominent role in susceptibility to SLE. The greatest risk of the development of SLE was detected in the individuals who had the combination of IFNGR1 Met14/Val14 genotype and IFNGR2 Gln64/Gln64 genotype.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalFEBS Letters
Volume453
Issue number1-2
DOIs
Publication statusPublished - 1999 Jun 18
Externally publishedYes

Fingerprint

Interferon Receptors
Polymorphism
Systemic Lupus Erythematosus
Amino Acids
Genotype
Gene Frequency
Population

Keywords

  • Genetic polymorphism
  • Interferon-γ receptor 1 (IFN-γR1)
  • Interferon-γ receptor 2 (IFN-γR2)
  • Susceptibility
  • Systemic lupus erythematosus (SLE)

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus. / Nakashima, Hitoshi; Inoue, Hisako; Akahoshi, Mitsuteru; Tanaka, Yosuke; Yamaoka, Kunihiro; Ogami, Eiichi; Nagano, Shuuji; Arinobu, Yojiro; Niiro, Hiroaki; Otsuka, Takeshi; Niho, Yoshiyuki.

In: FEBS Letters, Vol. 453, No. 1-2, 18.06.1999, p. 187-190.

Research output: Contribution to journal › Article

Nakashima, H, Inoue, H, Akahoshi, M, Tanaka, Y, Yamaoka, K, Ogami, E, Nagano, S, Arinobu, Y, Niiro, H, Otsuka, T & Niho, Y 1999, 'The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus', FEBS Letters, vol. 453, no. 1-2, pp. 187-190. https://doi.org/10.1016/S0014-5793(99)00701-2
Nakashima H, Inoue H, Akahoshi M, Tanaka Y, Yamaoka K, Ogami E et al. The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus. FEBS Letters. 1999 Jun 18;453(1-2):187-190. https://doi.org/10.1016/S0014-5793(99)00701-2
Nakashima, Hitoshi ; Inoue, Hisako ; Akahoshi, Mitsuteru ; Tanaka, Yosuke ; Yamaoka, Kunihiro ; Ogami, Eiichi ; Nagano, Shuuji ; Arinobu, Yojiro ; Niiro, Hiroaki ; Otsuka, Takeshi ; Niho, Yoshiyuki. / The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus. In: FEBS Letters. 1999 ; Vol. 453, No. 1-2. pp. 187-190.
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