TY - JOUR
T1 - The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus
AU - Nakashima, Hitoshi
AU - Inoue, Hisako
AU - Akahoshi, Mitsuteru
AU - Tanaka, Yosuke
AU - Yamaoka, Kunihiro
AU - Ogami, Eiichi
AU - Nagano, Shuuji
AU - Arinobu, Yojiro
AU - Niiro, Hiroaki
AU - Otsuka, Takeshi
AU - Niho, Yoshiyuki
PY - 1999/6/18
Y1 - 1999/6/18
N2 - Genetic factors seem to play a significant role in susceptibility to systemic lupus erythematosus (SLE). We previously described the amino acid polymorphism (Val14Met) within the IFN-γ receptor 1 (IFN-γR1), and that the frequency of the Met14 allele in SLE patients was significantly higher than that of the healthy control population. We also found an amino acid polymorphism (Gln64Arg) within IFN-γ receptor 2 (IFN-γR2). Since the IFN-γ receptor is a complex consisting of IFN-γR1 and IFN-γR2, we searched for the particular combination of two kinds of amino acid polymorphisms found within the IFN-γ receptor which plays a prominent role in susceptibility to SLE. The greatest risk of the development of SLE was detected in the individuals who had the combination of IFNGR1 Met14/Val14 genotype and IFNGR2 Gln64/Gln64 genotype.
AB - Genetic factors seem to play a significant role in susceptibility to systemic lupus erythematosus (SLE). We previously described the amino acid polymorphism (Val14Met) within the IFN-γ receptor 1 (IFN-γR1), and that the frequency of the Met14 allele in SLE patients was significantly higher than that of the healthy control population. We also found an amino acid polymorphism (Gln64Arg) within IFN-γ receptor 2 (IFN-γR2). Since the IFN-γ receptor is a complex consisting of IFN-γR1 and IFN-γR2, we searched for the particular combination of two kinds of amino acid polymorphisms found within the IFN-γ receptor which plays a prominent role in susceptibility to SLE. The greatest risk of the development of SLE was detected in the individuals who had the combination of IFNGR1 Met14/Val14 genotype and IFNGR2 Gln64/Gln64 genotype.
KW - Genetic polymorphism
KW - Interferon-γ receptor 1 (IFN-γR1)
KW - Interferon-γ receptor 2 (IFN-γR2)
KW - Susceptibility
KW - Systemic lupus erythematosus (SLE)
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U2 - 10.1016/S0014-5793(99)00701-2
DO - 10.1016/S0014-5793(99)00701-2
M3 - Article
C2 - 10403400
AN - SCOPUS:0032784571
VL - 453
SP - 187
EP - 190
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1-2
ER -