TY - JOUR
T1 - The common marmoset as a novel animal model system for biomedical and neuroscience research applications
AU - Okano, Hideyuki
AU - Hikishima, Keigo
AU - Iriki, Atsushi
AU - Sasaki, Erika
N1 - Funding Information:
This work was supported by grants from the “Highly creative animal model development for brain sciences” study carried out under the Strategic Research Program for Brain Sciences by grants from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and from the “Funding Program for World-leading Innovative R&D on Science and Technology” to H.O.
PY - 2012/12
Y1 - 2012/12
N2 - The common marmoset (Callithrix jacchus), a small New World primate, has been attracting much attention in the research field of biomedical science and neuroscience, based on its (i) cross-reactivity with human cytokines or hormones, (ii) comparative ease in handling due to its small size, (iii) high reproductive efficiency, (iv) establishment of basic research tools, and (v) advantages of its unique behavioral and cognitive characters. Various neurological disease models have been developed in the common marmoset, including Parkinson's disease, Huntington's disease, Alzheimer's disease, stroke, multiple sclerosis and spinal cord injury. We recently developed transgenic common marmoset with germline transmission, which is expected to provide a new animal model for the study of human diseases. In this review, we summarize the recent progress of biomedical research and neuroscience using common marmoset as an excellent model system.
AB - The common marmoset (Callithrix jacchus), a small New World primate, has been attracting much attention in the research field of biomedical science and neuroscience, based on its (i) cross-reactivity with human cytokines or hormones, (ii) comparative ease in handling due to its small size, (iii) high reproductive efficiency, (iv) establishment of basic research tools, and (v) advantages of its unique behavioral and cognitive characters. Various neurological disease models have been developed in the common marmoset, including Parkinson's disease, Huntington's disease, Alzheimer's disease, stroke, multiple sclerosis and spinal cord injury. We recently developed transgenic common marmoset with germline transmission, which is expected to provide a new animal model for the study of human diseases. In this review, we summarize the recent progress of biomedical research and neuroscience using common marmoset as an excellent model system.
KW - Common marmoset
KW - Non-human primate
KW - Spinal cord injury
KW - Transgenic technique
UR - http://www.scopus.com/inward/record.url?scp=84868301266&partnerID=8YFLogxK
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U2 - 10.1016/j.siny.2012.07.002
DO - 10.1016/j.siny.2012.07.002
M3 - Review article
C2 - 22871417
AN - SCOPUS:84868301266
SN - 1744-165X
VL - 17
SP - 336
EP - 340
JO - Seminars in Fetal and Neonatal Medicine
JF - Seminars in Fetal and Neonatal Medicine
IS - 6
ER -
