The comparison of solitary topical micafungin or fluconazole application in the treatment of Candida fungal keratitis

Yukihiro Matsumoto, Dogru Murat, Takashi Kojima, Jun Shimazaki, Kazuo Tsubota

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Aim: To compare and evaluate the efficacy of topical 0.1% micafungin (MCFG) and topical 0.2% fluconazole (FCZ) in the treatment of Candida fungal keratitis. Methods: Twenty-nine eyes of 29 patients who were diagnosed as having Candida fungal keratitis, proven by corneal culture isolates, were investigated in this prospective study. Patients were divided into a MCFG treatment group (12 eyes) and an FCZ treatment group (17 eyes). Age, gender, initial status of ulcer (ulcer size and degree of injection), initial and final best-corrected visual acuity (BCVA), healing periods, final status of cornea and recurrences in each group were studied and compared. Results: There were no significant differences in relation to age, gender, ulcer size and degree of injection before treatment between the two groups. There were also no significant differences in the healing periods until complete epithelialisation (MCFG treatment group (41.3±38.0 days); FCZ treatment group (34.4±37.7 days)), change in BCVA, corneal clarity/ opacification, perforation and recurrence status at the final examination between the two groups. Conclusion: The efficacy of 0.1% MCFG eye-drops appears to be comparable with that of 0.2% FCZ eye-drops in the treatment of Candida fungal keratitis.

Original languageEnglish
Pages (from-to)1406-1409
Number of pages4
JournalBritish Journal of Ophthalmology
Volume95
Issue number10
DOIs
Publication statusPublished - 2011 Oct

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Keratitis
Fluconazole
Candida
Ulcer
Ophthalmic Solutions
Therapeutics
Visual Acuity
Recurrence
Injections
micafungin
Cornea
Prospective Studies

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

The comparison of solitary topical micafungin or fluconazole application in the treatment of Candida fungal keratitis. / Matsumoto, Yukihiro; Murat, Dogru; Kojima, Takashi; Shimazaki, Jun; Tsubota, Kazuo.

In: British Journal of Ophthalmology, Vol. 95, No. 10, 10.2011, p. 1406-1409.

Research output: Contribution to journalArticle

Matsumoto, Yukihiro ; Murat, Dogru ; Kojima, Takashi ; Shimazaki, Jun ; Tsubota, Kazuo. / The comparison of solitary topical micafungin or fluconazole application in the treatment of Candida fungal keratitis. In: British Journal of Ophthalmology. 2011 ; Vol. 95, No. 10. pp. 1406-1409.
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