The complete remission of acquired immunodeficiency syndrome-associated isolated central nervous system lymphomatoid granulomatosis: A case report and review of the literature

Yasuhiro Kano; Minori Kodaira; Atsuhito Ushiki; Makoto Kosaka; Mitsunori Yamada; Kunihiko Shingu; Hiroshi Nishihara; Masayuki Hanaoka; Yoshiki Sekijima

doi:10.2169/internalmedicine.8776-16

The complete remission of acquired immunodeficiency syndrome-associated isolated central nervous system lymphomatoid granulomatosis: A case report and review of the literature

Yasuhiro Kano, Minori Kodaira, Atsuhito Ushiki, Makoto Kosaka, Mitsunori Yamada, Kunihiko Shingu, Hiroshi Nishihara, Masayuki Hanaoka, Yoshiki Sekijima

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

A 49-year-old man presented with gradually progressive aphasia one month after being diagnosed with acquired immunodeficiency syndrome (AIDS). Brain magnetic resonance imaging showed multiple brain lesions with punctate and linear enhancement. A polymerase chain reaction detected Epstein-Barr virus (EBV) in the patient’s cerebrospinal fluid. A diagnosis of isolated central nervous system lymphomatoid granulomatosis (CNS-LYG) was made based on the brain biopsy findings. The complete remission of CNS-LYG was achieved by anti-retroviral therapy (ART) alone. In the present case, the development of AIDS-associated CNS-LYG was considered to have been initiated by the reactivation of EBV in the CNS under immunosuppressive conditions. The patient’s condition improved with the reconstitution of the patient’s immune system.

Original language	English
Pages (from-to)	2497-2501
Number of pages	5
Journal	Internal Medicine
Volume	56
Issue number	18
DOIs	https://doi.org/10.2169/internalmedicine.8776-16
Publication status	Published - 2017
Externally published	Yes

Keywords

Acquired immunodeficiency syndrome
Anti-retroviral therapy
Central nervous system
Epstein-Barr virus
Lymphomatoid granulomatosis

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.8776-16

Cite this

Kano, Y., Kodaira, M., Ushiki, A., Kosaka, M., Yamada, M., Shingu, K., Nishihara, H., Hanaoka, M., & Sekijima, Y. (2017). The complete remission of acquired immunodeficiency syndrome-associated isolated central nervous system lymphomatoid granulomatosis: A case report and review of the literature. Internal Medicine, 56(18), 2497-2501. https://doi.org/10.2169/internalmedicine.8776-16

The complete remission of acquired immunodeficiency syndrome-associated isolated central nervous system lymphomatoid granulomatosis: A case report and review of the literature. / Kano, Yasuhiro; Kodaira, Minori; Ushiki, Atsuhito et al.
In: Internal Medicine, Vol. 56, No. 18, 2017, p. 2497-2501.

Research output: Contribution to journal › Review article › peer-review

Kano, Y, Kodaira, M, Ushiki, A, Kosaka, M, Yamada, M, Shingu, K, Nishihara, H, Hanaoka, M & Sekijima, Y 2017, 'The complete remission of acquired immunodeficiency syndrome-associated isolated central nervous system lymphomatoid granulomatosis: A case report and review of the literature', Internal Medicine, vol. 56, no. 18, pp. 2497-2501. https://doi.org/10.2169/internalmedicine.8776-16

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abstract = "A 49-year-old man presented with gradually progressive aphasia one month after being diagnosed with acquired immunodeficiency syndrome (AIDS). Brain magnetic resonance imaging showed multiple brain lesions with punctate and linear enhancement. A polymerase chain reaction detected Epstein-Barr virus (EBV) in the patient{\textquoteright}s cerebrospinal fluid. A diagnosis of isolated central nervous system lymphomatoid granulomatosis (CNS-LYG) was made based on the brain biopsy findings. The complete remission of CNS-LYG was achieved by anti-retroviral therapy (ART) alone. In the present case, the development of AIDS-associated CNS-LYG was considered to have been initiated by the reactivation of EBV in the CNS under immunosuppressive conditions. The patient{\textquoteright}s condition improved with the reconstitution of the patient{\textquoteright}s immune system.",

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author = "Yasuhiro Kano and Minori Kodaira and Atsuhito Ushiki and Makoto Kosaka and Mitsunori Yamada and Kunihiko Shingu and Hiroshi Nishihara and Masayuki Hanaoka and Yoshiki Sekijima",

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AU - Ushiki, Atsuhito

AU - Kosaka, Makoto

AU - Yamada, Mitsunori

AU - Shingu, Kunihiko

AU - Nishihara, Hiroshi

AU - Hanaoka, Masayuki

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AB - A 49-year-old man presented with gradually progressive aphasia one month after being diagnosed with acquired immunodeficiency syndrome (AIDS). Brain magnetic resonance imaging showed multiple brain lesions with punctate and linear enhancement. A polymerase chain reaction detected Epstein-Barr virus (EBV) in the patient’s cerebrospinal fluid. A diagnosis of isolated central nervous system lymphomatoid granulomatosis (CNS-LYG) was made based on the brain biopsy findings. The complete remission of CNS-LYG was achieved by anti-retroviral therapy (ART) alone. In the present case, the development of AIDS-associated CNS-LYG was considered to have been initiated by the reactivation of EBV in the CNS under immunosuppressive conditions. The patient’s condition improved with the reconstitution of the patient’s immune system.

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KW - Anti-retroviral therapy

KW - Central nervous system

KW - Epstein-Barr virus

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The complete remission of acquired immunodeficiency syndrome-associated isolated central nervous system lymphomatoid granulomatosis: A case report and review of the literature

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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