The complete remission of acquired immunodeficiency syndrome-associated isolated central nervous system lymphomatoid granulomatosis

A case report and review of the literature

Yasuhiro Kano, Minori Kodaira, Atsuhito Ushiki, Makoto Kosaka, Mitsunori Yamada, Kunihiko Shingu, Hiroshi Nishihara, Masayuki Hanaoka, Yoshiki Sekijima

Research output: Contribution to journalReview article

Abstract

A 49-year-old man presented with gradually progressive aphasia one month after being diagnosed with acquired immunodeficiency syndrome (AIDS). Brain magnetic resonance imaging showed multiple brain lesions with punctate and linear enhancement. A polymerase chain reaction detected Epstein-Barr virus (EBV) in the patient’s cerebrospinal fluid. A diagnosis of isolated central nervous system lymphomatoid granulomatosis (CNS-LYG) was made based on the brain biopsy findings. The complete remission of CNS-LYG was achieved by anti-retroviral therapy (ART) alone. In the present case, the development of AIDS-associated CNS-LYG was considered to have been initiated by the reactivation of EBV in the CNS under immunosuppressive conditions. The patient’s condition improved with the reconstitution of the patient’s immune system.

Original languageEnglish
Pages (from-to)2497-2501
Number of pages5
JournalInternal Medicine
Volume56
Issue number18
DOIs
Publication statusPublished - 2017 Jan 1
Externally publishedYes

Fingerprint

Lymphomatoid Granulomatosis
Acquired Immunodeficiency Syndrome
Central Nervous System
Human Herpesvirus 4
Brain
Aphasia
Immunosuppressive Agents
Cerebrospinal Fluid
Immune System
Magnetic Resonance Imaging
Biopsy
Polymerase Chain Reaction
Therapeutics

Keywords

  • Acquired immunodeficiency syndrome
  • Anti-retroviral therapy
  • Central nervous system
  • Epstein-Barr virus
  • Lymphomatoid granulomatosis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The complete remission of acquired immunodeficiency syndrome-associated isolated central nervous system lymphomatoid granulomatosis : A case report and review of the literature. / Kano, Yasuhiro; Kodaira, Minori; Ushiki, Atsuhito; Kosaka, Makoto; Yamada, Mitsunori; Shingu, Kunihiko; Nishihara, Hiroshi; Hanaoka, Masayuki; Sekijima, Yoshiki.

In: Internal Medicine, Vol. 56, No. 18, 01.01.2017, p. 2497-2501.

Research output: Contribution to journalReview article

Kano, Yasuhiro ; Kodaira, Minori ; Ushiki, Atsuhito ; Kosaka, Makoto ; Yamada, Mitsunori ; Shingu, Kunihiko ; Nishihara, Hiroshi ; Hanaoka, Masayuki ; Sekijima, Yoshiki. / The complete remission of acquired immunodeficiency syndrome-associated isolated central nervous system lymphomatoid granulomatosis : A case report and review of the literature. In: Internal Medicine. 2017 ; Vol. 56, No. 18. pp. 2497-2501.
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