The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: Novel oxygenase products from ω-3 polyunsaturated fatty acids

Makoto Arita, Clary B. Clish, Charles N. Serhan

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Resolvins (Rvs) are oxygenated products derived from ω-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid that carry potent protective bioactions present in resolving inflammatory exudates. Resolvin E1 (RvE1) is biosynthesized in vivo from EPA via transcellular biosynthetic routes during cell-cell interactions, and thus RvE1 is formed in vivo during multicellular responses such as inflammation and microbial infections. RvE1 protects tissues from leukocyte-mediated injury and counterregulates proinflammatory gene expression. These newly identified Rvs may underlie the beneficial actions of ω-3 PUFAs especially in chronic disorders where unresolved inflammation is a key mechanism of pathogenesis. Here, we present an overview of the biosynthesis of RvE1, with a focus on the aspirin-triggered and microbial P450-initiated pathways. The generation of RvE1 and its actions appear to dampen acute leukocyte responses and facilitate the resolution of inflammation.

Original languageEnglish
Pages (from-to)149-157
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume338
Issue number1
DOIs
Publication statusPublished - 2005 Dec 9
Externally publishedYes

Fingerprint

Oxygenases
Biosynthesis
Unsaturated Fatty Acids
Aspirin
Anti-Inflammatory Agents
Eicosapentaenoic Acid
Inflammation
Leukocytes
Docosahexaenoic Acids
Exudates and Transudates
Gene expression
Cell Communication
5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid
Tissue
Gene Expression
Wounds and Injuries
Infection

Keywords

  • ω-3 PUFA
  • Human leukocytes
  • Inflammation
  • Resolution

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

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AU - Serhan, Charles N.

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