The core structure of ginsenan PA, a phagocytosis-activating polysaccharide from the root of Panax ginseng

M. Tomoda, K. Hirabayashi, N. Shimizu, Ryoko Gonda, N. Ohara

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Controlled Smith degradation and limited hydrolysis of ginsenan PA, the main phagocytosis-activating polysaccharide isolated from the root of Panax ginseng C. A. Meyer, were performed. The reticuloendothelial system-potentiating and anti-complementary activities of the degradation products were investigated. Methylation analysis of the primary and secondary Smith degradation products indicated that the core structural features of ginsenan PA include a backbone chain mainly composed of β-1,3-linked D-galactose. Almost half of the galactose units in the backbone carry side-chains composed of β-1,6-linked D-galactosyl residues at position 6. Further 3,6-branching of D-galactose units was observed in a part of the side-chains. α-L-Arabinose units are connected mainly to the core galactose moieties via position 6. Removal of most of the arabinose units had a considerable effect on immunological activity.

Original languageEnglish
Pages (from-to)1287-1291
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume17
Issue number9
Publication statusPublished - 1994

Fingerprint

Panax
Galactose
Phagocytosis
Polysaccharides
Arabinose
Mononuclear Phagocyte System
Methylation
Hydrolysis
ginsenan PA

Keywords

  • core structure
  • de-arabinosylation
  • ginseng
  • immunological activity
  • polysaccharide
  • Smith degradation

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The core structure of ginsenan PA, a phagocytosis-activating polysaccharide from the root of Panax ginseng. / Tomoda, M.; Hirabayashi, K.; Shimizu, N.; Gonda, Ryoko; Ohara, N.

In: Biological and Pharmaceutical Bulletin, Vol. 17, No. 9, 1994, p. 1287-1291.

Research output: Contribution to journalArticle

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