The Core Structure of Ginsenan PA, a Phagocytosis-Activating Polysaccharide from the Root of Panax ginseng

Masashi Tomoda, Keiko Hirabayashi, Noriko Shimizu, Ryoko Gonda, Naoko Ohara

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Controlled Smith degradation and limited hydrolysis of ginsenan PA, the main phagocytosis-activating polysaccharide isolated from the root of Panax ginseng C. A. meyer, were performed. The reticuloendothelial system-potentiating and anti-complementary activities of the degradation products were investigated. Methylation analysis of the primary and secondary Smith degradation products indicated that the core structural features of ginsenan PA include a backbone chain mainly composed of β-1, 3-linked D-galactose. Almost half of the galactose units in the backbone carry side-chains composed of β-1, 6-linked D-galactosyl residues at position 6. Further 3, 6-branching of D-galactose units was observed in a part of the side-chains. a-L-Arabinose units are connected mainly to the core galactose moieties via position 6. Removal of most of the arabinose units had a considerable effect on immunological activity.

Original languageEnglish
Pages (from-to)1287-1291
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume17
Issue number9
DOIs
Publication statusPublished - 1994 Jan 1

Keywords

  • Smith degradation
  • core structure
  • de-arabinosylation
  • ginseng
  • immunological activity
  • polysaccharide

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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