The core structure of ukonan A, a phagocytosis-activating polysaccharide from the Rhizome of Curcuma longa, and immunological activities of degradation products

Ryoko Gonda, M. Tomoda, K. Takada, N. Ohara, N. Shimizu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The controlled Smith degradation of ukonan A, a phagocytosis-activating polysaccharide isolated from the rhizome of Curcuma longa L., was performed. The reticuloendothelial system-potentiating, anti-complementary and alkaline phosphatase-inducing activities of ukonan A and its degradation products were investigated. Methylation analyses of both the primary and the secondary Smith degradation products indicated that the core structural features of ukonan A include a backbone chain mainly composed of β-1,3-linked D-galactose, β-1,4-linked D-xylose and α-1,2-linked L-rhamnose residues. All of the galactose units in the backbone carry side chains composed of α-L-arabino-β-D-galactosyl or β-D-galactosyl residues at position 6. Ukonan A has a remarkable effect on each of the three kinds of immunological activities. Periodate oxidation caused pronounced decrease or disappearance of the activities, but the controlled Smith degradation product having the core structure of polysaccharide showed considerable restoration of these activities.

Original languageEnglish
Pages (from-to)990-993
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number4
Publication statusPublished - 1992

Fingerprint

Curcuma
Rhizome
Phagocytosis
Polysaccharides
Thermodynamic properties
Degradation
Galactose
Rhamnose
Mononuclear Phagocyte System
Methylation
Xylose
Restoration
Alkaline Phosphatase
Oxidation
ukonan A

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

The core structure of ukonan A, a phagocytosis-activating polysaccharide from the Rhizome of Curcuma longa, and immunological activities of degradation products. / Gonda, Ryoko; Tomoda, M.; Takada, K.; Ohara, N.; Shimizu, N.

In: Chemical and Pharmaceutical Bulletin, Vol. 40, No. 4, 1992, p. 990-993.

Research output: Contribution to journalArticle

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AU - Ohara, N.

AU - Shimizu, N.

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