TY - JOUR
T1 - The determinants of plasma plasminogen activator inhibitor-1 levels differ for American and Japanese men aged 40-49
AU - Takamiya, Tomoko
AU - Kadowaki, Takashi
AU - Zaky, Wahid R.
AU - Ueshima, Hirotsugu
AU - Evans, Rhobert W.
AU - Okamura, Tomonori
AU - Kashiwagi, Atsunori
AU - Nakamura, Yasuyuki
AU - Kita, Yoshiyuki
AU - Tracy, Russell P.
AU - Kuller, Lewis H.
AU - Sekikawa, Akira
N1 - Funding Information:
This research is supported by grants (beginning grant-in-aid by the American Heart Association (0160512U) and R01 by the National Institutes of Health (HL068200), grant-in-aid for scientific research by the Japanese Ministry of Education, Culture, Sports, Science and Technology ((A): 13307016) and grant-in-aid for young scientists by the Japanese Ministry of Education, Culture, Sports, Science and Technology ((B): 16790335). We thank Ms. Beth Hauth for analyzing the blood samples at the Heinz Laboratory.
PY - 2006/5
Y1 - 2006/5
N2 - Background: Elevated plasma plasminogen activator inhibitor-1 (PAI-1) levels were associated with higher incidence of type II diabetes. Elucidating the determinants of PAI-1 in various ethnicities may help to understand the susceptibility to developing diabetes. The aim of our study was to compare PAI-1 levels between Americans and the Japanese in the post-war generation and to elucidate the determinants of the PAI-1 levels. Methods: We conducted a cross-sectional study on a total of 198 men aged 40-49 in the US (Body mass index (BMI): 27.0 ± 3.3 kg/m2) and Japan (BMI: 23.3 ± 3.1 kg/m2). Examination included physique measurement (BMI and waist girth), blood analysis (lipid profiles, glucose, insulin, C-reactive protein, and PAI-1), and life-style assessment by self-administered questionnaires. Results: PAI-1 levels were significantly lower in American than in Japanese men, even after adjustment for age, waist girth, cigarette smoking, habitual alcohol drinking, and other factors. In the Americans, waist girth, insulin, and cigarette smoking were significantly associated with PAI-1 levels, while waist girth and triglycerides were significantly associated with PAI-1 levels in the Japanese. Conclusions: PAI-1 levels were significantly lower in American than in Japanese men and the determinants of PAI-1 levels differ for American and Japanese men aged 40-49.
AB - Background: Elevated plasma plasminogen activator inhibitor-1 (PAI-1) levels were associated with higher incidence of type II diabetes. Elucidating the determinants of PAI-1 in various ethnicities may help to understand the susceptibility to developing diabetes. The aim of our study was to compare PAI-1 levels between Americans and the Japanese in the post-war generation and to elucidate the determinants of the PAI-1 levels. Methods: We conducted a cross-sectional study on a total of 198 men aged 40-49 in the US (Body mass index (BMI): 27.0 ± 3.3 kg/m2) and Japan (BMI: 23.3 ± 3.1 kg/m2). Examination included physique measurement (BMI and waist girth), blood analysis (lipid profiles, glucose, insulin, C-reactive protein, and PAI-1), and life-style assessment by self-administered questionnaires. Results: PAI-1 levels were significantly lower in American than in Japanese men, even after adjustment for age, waist girth, cigarette smoking, habitual alcohol drinking, and other factors. In the Americans, waist girth, insulin, and cigarette smoking were significantly associated with PAI-1 levels, while waist girth and triglycerides were significantly associated with PAI-1 levels in the Japanese. Conclusions: PAI-1 levels were significantly lower in American than in Japanese men and the determinants of PAI-1 levels differ for American and Japanese men aged 40-49.
KW - Epidemiology
KW - Japan
KW - PAI-1
KW - Post-war generation
KW - US
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U2 - 10.1016/j.diabres.2005.10.015
DO - 10.1016/j.diabres.2005.10.015
M3 - Article
C2 - 16325297
AN - SCOPUS:33646121504
SN - 0168-8227
VL - 72
SP - 176
EP - 182
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 2
ER -
