The direct and enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes

Yujiro Hayashi, Wataru Tsuboi, Itaru Ashimine, Tatsuya Urushima, Mitsuru Shoji, Ken Sakai

Research output: Contribution to journalArticle

293 Citations (Scopus)

Abstract

A double-crossed reaction: The use of proline as an organocatalyst enables a one-pot, direct, cross-Mannich reaction to be performed between two different aldehydes and 4-methoxyaniline in a highly syn-diastereo- and enantioselective manner (see scheme).

Original languageEnglish
Pages (from-to)3677-3680
Number of pages4
JournalAngewandte Chemie - International Edition
Volume42
Issue number31
DOIs
Publication statusPublished - 2003 Aug 11
Externally publishedYes

Fingerprint

Aldehydes
Proline
4-anisidine

Keywords

  • Aldehydes
  • Asymmetric synthesis
  • Enantioselectivity
  • Organocatalysts
  • Three-component reaction

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

The direct and enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes. / Hayashi, Yujiro; Tsuboi, Wataru; Ashimine, Itaru; Urushima, Tatsuya; Shoji, Mitsuru; Sakai, Ken.

In: Angewandte Chemie - International Edition, Vol. 42, No. 31, 11.08.2003, p. 3677-3680.

Research output: Contribution to journalArticle

Hayashi, Yujiro ; Tsuboi, Wataru ; Ashimine, Itaru ; Urushima, Tatsuya ; Shoji, Mitsuru ; Sakai, Ken. / The direct and enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes. In: Angewandte Chemie - International Edition. 2003 ; Vol. 42, No. 31. pp. 3677-3680.
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