The direct and enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes

Yujiro Hayashi, Wataru Tsuboi, Itaru Ashimine, Tatsuya Urushima, Mitsuru Shoji, Ken Sakai

Research output: Contribution to journalArticle

295 Citations (Scopus)

Abstract

A double-crossed reaction: The use of proline as an organocatalyst enables a one-pot, direct, cross-Mannich reaction to be performed between two different aldehydes and 4-methoxyaniline in a highly syn-diastereo- and enantioselective manner (see scheme).

Original languageEnglish
Pages (from-to)3677-3680
Number of pages4
JournalAngewandte Chemie - International Edition
Volume42
Issue number31
DOIs
Publication statusPublished - 2003 Aug 11

Keywords

  • Aldehydes
  • Asymmetric synthesis
  • Enantioselectivity
  • Organocatalysts
  • Three-component reaction

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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