The DNA sequence of human chromosome 22

I. Dunham, N. Shimizu, B. A. Roe, S. Chissoe, I. Dunham, A. R. Hunt, J. E. Collins, R. Bruskiewich, D. M. Beare, M. Clamp, L. J. Smink, R. Ainscough, J. P. Almeida, A. Babbage, C. Bagguley, J. Bailey, K. Barlow, K. N. Bates, O. Beasley, C. P. BirdS. Blakey, A. M. Bridgeman, D. Buck, J. Burgess, W. D. Burrill, J. Burton, C. Carder, N. P. Carter, Y. Chen, G. Clark, S. M. Clegg, V. Cobley, C. G. Cole, R. E. Collier, R. E. Connor, D. Conroy, N. Corby, G. J. Coville, A. V. Cox, J. Davis, E. Dawson, P. D. Dhami, C. Dockree, S. J. Dodsworth, R. M. Durbin, A. Ellington, K. L. Evans, J. M. Fey, K. Fleming, L. French, A. A. Garner, J. G R Gilbert, M. E. Goward, D. Grafham, M. N. Griffiths, C. Hall, R. Hall, G. Hall-Tamlyn, R. W. Heathcott, S. Ho, S. Holmes, S. E. Hunt, M. C. Jones, J. Kershaw, A. Kimberley, A. King, G. K. Laird, C. F. Langford, M. A. Leversha, C. Lloyd, D. M. Lloyd, I. D. Martyn, M. Mashreghi-Mohammadi, L. Matthews, O. T. Mccann, J. Mcclay, S. Mclaren, A. A. Mcmurray, S. A. Milne, B. J. Mortimore, C. N. Odell, R. Pavitt, A. V. Pearce, D. Pearson, B. J. Phillimore, S. H. Phillips, R. W. Plumb, H. Ramsay, Y. Ramsey, L. Rogers, M. T. Ross, C. E. Scott, H. K. Sehra, C. D. Skuce, S. Smalley, M. L. Smith, C. Soderlund, L. Spragon, C. A. Steward, J. E. Sulston, R. M. Swann, M. Vaudin, M. Wall, J. M. Wallis, M. N. Whiteley, D. Willey, L. Williams, S. Williams, H. Williamson, T. E. Wilmer, L. Wilming, C. L. Wright, T. Hubbard, D. R. Bentley, S. Beck, J. Rogers, N. Shimizu, S. Minoshima, K. Kawasaki, Takashi Sasaki, S. Asakawa, Jun Kudo, A. Shintani, Kazunori Shibuya, Y. Yoshizaki, N. Aoki, S. Mitsuyama, B. A. Roe, F. Chen, L. Chu, J. Crabtree, S. Deschamps, A. Do, T. Do, A. Dorman, F. Fang, Y. Fu, P. Hu, A. Hua, S. Kenton, H. Lai, H. I. Lao, J. Lewis, S. Lewis, S. P. Lin, P. Loh, E. Malaj, T. Nguyen, H. Pan, S. Phan, S. Qi, Y. Qian, L. Ray, Q. Ren, S. Shaull, D. Sloan, L. Song, Q. Wang, Y. Wang, Z. Wang, J. White, D. Willingham, H. Wu, Z. Yao, M. Zhan, G. Zhang, S. Chissoe, J. Murray, N. Miller, P. Minx, R. Fulton, D. Johnson, G. Bemis, D. Bentley, H. Bradshaw, S. Bourne, M. Cordes, Z. Du, L. Fulton, D. Goela, T. Graves, J. Hawkins, K. Hinds, K. Kemp, P. Latreille, D. Layman, P. Ozersky, T. Rohlfing, P. Scheet, C. Walker, A. Wamsley, P. Wohldmann, K. Pepin, J. Nelson, I. Korf, J. A. Bedell, L. Hillier, E. Mardis, R. Waterston, R. Wilson, B. S. Emanuel, T. Shaikh, H. Kurahashi, S. Saitta, M. L. Budarf, H. E. Mcdermid, A. Johnson, A. C C Wong, B. E. Morrow, L. Edelmann, U. J. Kim, H. Shizuya, M. I. Simon, J. P. Dumanski, M. Peyrard, D. Kedra, E. Seroussi, I. Fransson, I. Tapia, C. E. Bruder, K. P. O'Brien

Research output: Contribution to journalArticle

872 Citations (Scopus)

Abstract

Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. Furthermore, the sequence is a rich and permanent source of information for the design of further biological studies of the organism and for the study of evolution through cross-species sequence comparison. The power of this approach has been amply demonstrated by the determination of the sequences of a number of microbial and model organisms. The next step is to obtain the complete sequence of the entire human genome. Here we report the sequence of the euchromatic part of human chromosome 22. The sequence obtained consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome.

Original languageEnglish
Pages (from-to)489-495
Number of pages7
JournalNature
Volume402
Issue number6761
DOIs
Publication statusPublished - 1999 Dec 2

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Chromosomes, Human, Pair 22
Human Chromosomes
Pseudogenes
Human Genome
Genes
Sequence Analysis
Genome
Proteins

ASJC Scopus subject areas

  • General

Cite this

Dunham, I., Shimizu, N., Roe, B. A., Chissoe, S., Dunham, I., Hunt, A. R., ... O'Brien, K. P. (1999). The DNA sequence of human chromosome 22. Nature, 402(6761), 489-495. https://doi.org/10.1038/990031

The DNA sequence of human chromosome 22. / Dunham, I.; Shimizu, N.; Roe, B. A.; Chissoe, S.; Dunham, I.; Hunt, A. R.; Collins, J. E.; Bruskiewich, R.; Beare, D. M.; Clamp, M.; Smink, L. J.; Ainscough, R.; Almeida, J. P.; Babbage, A.; Bagguley, C.; Bailey, J.; Barlow, K.; Bates, K. N.; Beasley, O.; Bird, C. P.; Blakey, S.; Bridgeman, A. M.; Buck, D.; Burgess, J.; Burrill, W. D.; Burton, J.; Carder, C.; Carter, N. P.; Chen, Y.; Clark, G.; Clegg, S. M.; Cobley, V.; Cole, C. G.; Collier, R. E.; Connor, R. E.; Conroy, D.; Corby, N.; Coville, G. J.; Cox, A. V.; Davis, J.; Dawson, E.; Dhami, P. D.; Dockree, C.; Dodsworth, S. J.; Durbin, R. M.; Ellington, A.; Evans, K. L.; Fey, J. M.; Fleming, K.; French, L.; Garner, A. A.; Gilbert, J. G R; Goward, M. E.; Grafham, D.; Griffiths, M. N.; Hall, C.; Hall, R.; Hall-Tamlyn, G.; Heathcott, R. W.; Ho, S.; Holmes, S.; Hunt, S. E.; Jones, M. C.; Kershaw, J.; Kimberley, A.; King, A.; Laird, G. K.; Langford, C. F.; Leversha, M. A.; Lloyd, C.; Lloyd, D. M.; Martyn, I. D.; Mashreghi-Mohammadi, M.; Matthews, L.; Mccann, O. T.; Mcclay, J.; Mclaren, S.; Mcmurray, A. A.; Milne, S. A.; Mortimore, B. J.; Odell, C. N.; Pavitt, R.; Pearce, A. V.; Pearson, D.; Phillimore, B. J.; Phillips, S. H.; Plumb, R. W.; Ramsay, H.; Ramsey, Y.; Rogers, L.; Ross, M. T.; Scott, C. E.; Sehra, H. K.; Skuce, C. D.; Smalley, S.; Smith, M. L.; Soderlund, C.; Spragon, L.; Steward, C. A.; Sulston, J. E.; Swann, R. M.; Vaudin, M.; Wall, M.; Wallis, J. M.; Whiteley, M. N.; Willey, D.; Williams, L.; Williams, S.; Williamson, H.; Wilmer, T. E.; Wilming, L.; Wright, C. L.; Hubbard, T.; Bentley, D. R.; Beck, S.; Rogers, J.; Shimizu, N.; Minoshima, S.; Kawasaki, K.; Sasaki, Takashi; Asakawa, S.; Kudo, Jun; Shintani, A.; Shibuya, Kazunori; Yoshizaki, Y.; Aoki, N.; Mitsuyama, S.; Roe, B. A.; Chen, F.; Chu, L.; Crabtree, J.; Deschamps, S.; Do, A.; Do, T.; Dorman, A.; Fang, F.; Fu, Y.; Hu, P.; Hua, A.; Kenton, S.; Lai, H.; Lao, H. I.; Lewis, J.; Lewis, S.; Lin, S. P.; Loh, P.; Malaj, E.; Nguyen, T.; Pan, H.; Phan, S.; Qi, S.; Qian, Y.; Ray, L.; Ren, Q.; Shaull, S.; Sloan, D.; Song, L.; Wang, Q.; Wang, Y.; Wang, Z.; White, J.; Willingham, D.; Wu, H.; Yao, Z.; Zhan, M.; Zhang, G.; Chissoe, S.; Murray, J.; Miller, N.; Minx, P.; Fulton, R.; Johnson, D.; Bemis, G.; Bentley, D.; Bradshaw, H.; Bourne, S.; Cordes, M.; Du, Z.; Fulton, L.; Goela, D.; Graves, T.; Hawkins, J.; Hinds, K.; Kemp, K.; Latreille, P.; Layman, D.; Ozersky, P.; Rohlfing, T.; Scheet, P.; Walker, C.; Wamsley, A.; Wohldmann, P.; Pepin, K.; Nelson, J.; Korf, I.; Bedell, J. A.; Hillier, L.; Mardis, E.; Waterston, R.; Wilson, R.; Emanuel, B. S.; Shaikh, T.; Kurahashi, H.; Saitta, S.; Budarf, M. L.; Mcdermid, H. E.; Johnson, A.; Wong, A. C C; Morrow, B. E.; Edelmann, L.; Kim, U. J.; Shizuya, H.; Simon, M. I.; Dumanski, J. P.; Peyrard, M.; Kedra, D.; Seroussi, E.; Fransson, I.; Tapia, I.; Bruder, C. E.; O'Brien, K. P.

In: Nature, Vol. 402, No. 6761, 02.12.1999, p. 489-495.

Research output: Contribution to journalArticle

Dunham, I, Shimizu, N, Roe, BA, Chissoe, S, Dunham, I, Hunt, AR, Collins, JE, Bruskiewich, R, Beare, DM, Clamp, M, Smink, LJ, Ainscough, R, Almeida, JP, Babbage, A, Bagguley, C, Bailey, J, Barlow, K, Bates, KN, Beasley, O, Bird, CP, Blakey, S, Bridgeman, AM, Buck, D, Burgess, J, Burrill, WD, Burton, J, Carder, C, Carter, NP, Chen, Y, Clark, G, Clegg, SM, Cobley, V, Cole, CG, Collier, RE, Connor, RE, Conroy, D, Corby, N, Coville, GJ, Cox, AV, Davis, J, Dawson, E, Dhami, PD, Dockree, C, Dodsworth, SJ, Durbin, RM, Ellington, A, Evans, KL, Fey, JM, Fleming, K, French, L, Garner, AA, Gilbert, JGR, Goward, ME, Grafham, D, Griffiths, MN, Hall, C, Hall, R, Hall-Tamlyn, G, Heathcott, RW, Ho, S, Holmes, S, Hunt, SE, Jones, MC, Kershaw, J, Kimberley, A, King, A, Laird, GK, Langford, CF, Leversha, MA, Lloyd, C, Lloyd, DM, Martyn, ID, Mashreghi-Mohammadi, M, Matthews, L, Mccann, OT, Mcclay, J, Mclaren, S, Mcmurray, AA, Milne, SA, Mortimore, BJ, Odell, CN, Pavitt, R, Pearce, AV, Pearson, D, Phillimore, BJ, Phillips, SH, Plumb, RW, Ramsay, H, Ramsey, Y, Rogers, L, Ross, MT, Scott, CE, Sehra, HK, Skuce, CD, Smalley, S, Smith, ML, Soderlund, C, Spragon, L, Steward, CA, Sulston, JE, Swann, RM, Vaudin, M, Wall, M, Wallis, JM, Whiteley, MN, Willey, D, Williams, L, Williams, S, Williamson, H, Wilmer, TE, Wilming, L, Wright, CL, Hubbard, T, Bentley, DR, Beck, S, Rogers, J, Shimizu, N, Minoshima, S, Kawasaki, K, Sasaki, T, Asakawa, S, Kudo, J, Shintani, A, Shibuya, K, Yoshizaki, Y, Aoki, N, Mitsuyama, S, Roe, BA, Chen, F, Chu, L, Crabtree, J, Deschamps, S, Do, A, Do, T, Dorman, A, Fang, F, Fu, Y, Hu, P, Hua, A, Kenton, S, Lai, H, Lao, HI, Lewis, J, Lewis, S, Lin, SP, Loh, P, Malaj, E, Nguyen, T, Pan, H, Phan, S, Qi, S, Qian, Y, Ray, L, Ren, Q, Shaull, S, Sloan, D, Song, L, Wang, Q, Wang, Y, Wang, Z, White, J, Willingham, D, Wu, H, Yao, Z, Zhan, M, Zhang, G, Chissoe, S, Murray, J, Miller, N, Minx, P, Fulton, R, Johnson, D, Bemis, G, Bentley, D, Bradshaw, H, Bourne, S, Cordes, M, Du, Z, Fulton, L, Goela, D, Graves, T, Hawkins, J, Hinds, K, Kemp, K, Latreille, P, Layman, D, Ozersky, P, Rohlfing, T, Scheet, P, Walker, C, Wamsley, A, Wohldmann, P, Pepin, K, Nelson, J, Korf, I, Bedell, JA, Hillier, L, Mardis, E, Waterston, R, Wilson, R, Emanuel, BS, Shaikh, T, Kurahashi, H, Saitta, S, Budarf, ML, Mcdermid, HE, Johnson, A, Wong, ACC, Morrow, BE, Edelmann, L, Kim, UJ, Shizuya, H, Simon, MI, Dumanski, JP, Peyrard, M, Kedra, D, Seroussi, E, Fransson, I, Tapia, I, Bruder, CE & O'Brien, KP 1999, 'The DNA sequence of human chromosome 22', Nature, vol. 402, no. 6761, pp. 489-495. https://doi.org/10.1038/990031
Dunham I, Shimizu N, Roe BA, Chissoe S, Dunham I, Hunt AR et al. The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-495. https://doi.org/10.1038/990031
Dunham, I. ; Shimizu, N. ; Roe, B. A. ; Chissoe, S. ; Dunham, I. ; Hunt, A. R. ; Collins, J. E. ; Bruskiewich, R. ; Beare, D. M. ; Clamp, M. ; Smink, L. J. ; Ainscough, R. ; Almeida, J. P. ; Babbage, A. ; Bagguley, C. ; Bailey, J. ; Barlow, K. ; Bates, K. N. ; Beasley, O. ; Bird, C. P. ; Blakey, S. ; Bridgeman, A. M. ; Buck, D. ; Burgess, J. ; Burrill, W. D. ; Burton, J. ; Carder, C. ; Carter, N. P. ; Chen, Y. ; Clark, G. ; Clegg, S. M. ; Cobley, V. ; Cole, C. G. ; Collier, R. E. ; Connor, R. E. ; Conroy, D. ; Corby, N. ; Coville, G. J. ; Cox, A. V. ; Davis, J. ; Dawson, E. ; Dhami, P. D. ; Dockree, C. ; Dodsworth, S. J. ; Durbin, R. M. ; Ellington, A. ; Evans, K. L. ; Fey, J. M. ; Fleming, K. ; French, L. ; Garner, A. A. ; Gilbert, J. G R ; Goward, M. E. ; Grafham, D. ; Griffiths, M. N. ; Hall, C. ; Hall, R. ; Hall-Tamlyn, G. ; Heathcott, R. W. ; Ho, S. ; Holmes, S. ; Hunt, S. E. ; Jones, M. C. ; Kershaw, J. ; Kimberley, A. ; King, A. ; Laird, G. K. ; Langford, C. F. ; Leversha, M. A. ; Lloyd, C. ; Lloyd, D. M. ; Martyn, I. D. ; Mashreghi-Mohammadi, M. ; Matthews, L. ; Mccann, O. T. ; Mcclay, J. ; Mclaren, S. ; Mcmurray, A. A. ; Milne, S. A. ; Mortimore, B. J. ; Odell, C. N. ; Pavitt, R. ; Pearce, A. V. ; Pearson, D. ; Phillimore, B. J. ; Phillips, S. H. ; Plumb, R. W. ; Ramsay, H. ; Ramsey, Y. ; Rogers, L. ; Ross, M. T. ; Scott, C. E. ; Sehra, H. K. ; Skuce, C. D. ; Smalley, S. ; Smith, M. L. ; Soderlund, C. ; Spragon, L. ; Steward, C. A. ; Sulston, J. E. ; Swann, R. M. ; Vaudin, M. ; Wall, M. ; Wallis, J. M. ; Whiteley, M. N. ; Willey, D. ; Williams, L. ; Williams, S. ; Williamson, H. ; Wilmer, T. E. ; Wilming, L. ; Wright, C. L. ; Hubbard, T. ; Bentley, D. R. ; Beck, S. ; Rogers, J. ; Shimizu, N. ; Minoshima, S. ; Kawasaki, K. ; Sasaki, Takashi ; Asakawa, S. ; Kudo, Jun ; Shintani, A. ; Shibuya, Kazunori ; Yoshizaki, Y. ; Aoki, N. ; Mitsuyama, S. ; Roe, B. A. ; Chen, F. ; Chu, L. ; Crabtree, J. ; Deschamps, S. ; Do, A. ; Do, T. ; Dorman, A. ; Fang, F. ; Fu, Y. ; Hu, P. ; Hua, A. ; Kenton, S. ; Lai, H. ; Lao, H. I. ; Lewis, J. ; Lewis, S. ; Lin, S. P. ; Loh, P. ; Malaj, E. ; Nguyen, T. ; Pan, H. ; Phan, S. ; Qi, S. ; Qian, Y. ; Ray, L. ; Ren, Q. ; Shaull, S. ; Sloan, D. ; Song, L. ; Wang, Q. ; Wang, Y. ; Wang, Z. ; White, J. ; Willingham, D. ; Wu, H. ; Yao, Z. ; Zhan, M. ; Zhang, G. ; Chissoe, S. ; Murray, J. ; Miller, N. ; Minx, P. ; Fulton, R. ; Johnson, D. ; Bemis, G. ; Bentley, D. ; Bradshaw, H. ; Bourne, S. ; Cordes, M. ; Du, Z. ; Fulton, L. ; Goela, D. ; Graves, T. ; Hawkins, J. ; Hinds, K. ; Kemp, K. ; Latreille, P. ; Layman, D. ; Ozersky, P. ; Rohlfing, T. ; Scheet, P. ; Walker, C. ; Wamsley, A. ; Wohldmann, P. ; Pepin, K. ; Nelson, J. ; Korf, I. ; Bedell, J. A. ; Hillier, L. ; Mardis, E. ; Waterston, R. ; Wilson, R. ; Emanuel, B. S. ; Shaikh, T. ; Kurahashi, H. ; Saitta, S. ; Budarf, M. L. ; Mcdermid, H. E. ; Johnson, A. ; Wong, A. C C ; Morrow, B. E. ; Edelmann, L. ; Kim, U. J. ; Shizuya, H. ; Simon, M. I. ; Dumanski, J. P. ; Peyrard, M. ; Kedra, D. ; Seroussi, E. ; Fransson, I. ; Tapia, I. ; Bruder, C. E. ; O'Brien, K. P. / The DNA sequence of human chromosome 22. In: Nature. 1999 ; Vol. 402, No. 6761. pp. 489-495.
@article{5e2b48d69d364d17b140ea2fbfc70adc,
title = "The DNA sequence of human chromosome 22",
abstract = "Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. Furthermore, the sequence is a rich and permanent source of information for the design of further biological studies of the organism and for the study of evolution through cross-species sequence comparison. The power of this approach has been amply demonstrated by the determination of the sequences of a number of microbial and model organisms. The next step is to obtain the complete sequence of the entire human genome. Here we report the sequence of the euchromatic part of human chromosome 22. The sequence obtained consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome.",
author = "I. Dunham and N. Shimizu and Roe, {B. A.} and S. Chissoe and I. Dunham and Hunt, {A. R.} and Collins, {J. E.} and R. Bruskiewich and Beare, {D. M.} and M. Clamp and Smink, {L. J.} and R. Ainscough and Almeida, {J. P.} and A. Babbage and C. Bagguley and J. Bailey and K. Barlow and Bates, {K. N.} and O. Beasley and Bird, {C. P.} and S. Blakey and Bridgeman, {A. M.} and D. Buck and J. Burgess and Burrill, {W. D.} and J. Burton and C. Carder and Carter, {N. P.} and Y. Chen and G. Clark and Clegg, {S. M.} and V. Cobley and Cole, {C. G.} and Collier, {R. E.} and Connor, {R. E.} and D. Conroy and N. Corby and Coville, {G. J.} and Cox, {A. V.} and J. Davis and E. Dawson and Dhami, {P. D.} and C. Dockree and Dodsworth, {S. J.} and Durbin, {R. M.} and A. Ellington and Evans, {K. L.} and Fey, {J. M.} and K. Fleming and L. French and Garner, {A. A.} and Gilbert, {J. G R} and Goward, {M. E.} and D. Grafham and Griffiths, {M. N.} and C. Hall and R. Hall and G. Hall-Tamlyn and Heathcott, {R. W.} and S. Ho and S. Holmes and Hunt, {S. E.} and Jones, {M. C.} and J. Kershaw and A. Kimberley and A. King and Laird, {G. K.} and Langford, {C. F.} and Leversha, {M. A.} and C. Lloyd and Lloyd, {D. M.} and Martyn, {I. D.} and M. Mashreghi-Mohammadi and L. Matthews and Mccann, {O. T.} and J. Mcclay and S. Mclaren and Mcmurray, {A. A.} and Milne, {S. A.} and Mortimore, {B. J.} and Odell, {C. N.} and R. Pavitt and Pearce, {A. V.} and D. Pearson and Phillimore, {B. J.} and Phillips, {S. H.} and Plumb, {R. W.} and H. Ramsay and Y. Ramsey and L. Rogers and Ross, {M. T.} and Scott, {C. E.} and Sehra, {H. K.} and Skuce, {C. D.} and S. Smalley and Smith, {M. L.} and C. Soderlund and L. Spragon and Steward, {C. A.} and Sulston, {J. E.} and Swann, {R. M.} and M. Vaudin and M. Wall and Wallis, {J. M.} and Whiteley, {M. N.} and D. Willey and L. Williams and S. Williams and H. Williamson and Wilmer, {T. E.} and L. Wilming and Wright, {C. L.} and T. Hubbard and Bentley, {D. R.} and S. Beck and J. Rogers and N. Shimizu and S. Minoshima and K. Kawasaki and Takashi Sasaki and S. Asakawa and Jun Kudo and A. Shintani and Kazunori Shibuya and Y. Yoshizaki and N. Aoki and S. Mitsuyama and Roe, {B. A.} and F. Chen and L. Chu and J. Crabtree and S. Deschamps and A. Do and T. Do and A. Dorman and F. Fang and Y. Fu and P. Hu and A. Hua and S. Kenton and H. Lai and Lao, {H. I.} and J. Lewis and S. Lewis and Lin, {S. P.} and P. Loh and E. Malaj and T. Nguyen and H. Pan and S. Phan and S. Qi and Y. Qian and L. Ray and Q. Ren and S. Shaull and D. Sloan and L. Song and Q. Wang and Y. Wang and Z. Wang and J. White and D. Willingham and H. Wu and Z. Yao and M. Zhan and G. Zhang and S. Chissoe and J. Murray and N. Miller and P. Minx and R. Fulton and D. Johnson and G. Bemis and D. Bentley and H. Bradshaw and S. Bourne and M. Cordes and Z. Du and L. Fulton and D. Goela and T. Graves and J. Hawkins and K. Hinds and K. Kemp and P. Latreille and D. Layman and P. Ozersky and T. Rohlfing and P. Scheet and C. Walker and A. Wamsley and P. Wohldmann and K. Pepin and J. Nelson and I. Korf and Bedell, {J. A.} and L. Hillier and E. Mardis and R. Waterston and R. Wilson and Emanuel, {B. S.} and T. Shaikh and H. Kurahashi and S. Saitta and Budarf, {M. L.} and Mcdermid, {H. E.} and A. Johnson and Wong, {A. C C} and Morrow, {B. E.} and L. Edelmann and Kim, {U. J.} and H. Shizuya and Simon, {M. I.} and Dumanski, {J. P.} and M. Peyrard and D. Kedra and E. Seroussi and I. Fransson and I. Tapia and Bruder, {C. E.} and O'Brien, {K. P.}",
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pages = "489--495",
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TY - JOUR

T1 - The DNA sequence of human chromosome 22

AU - Dunham, I.

AU - Shimizu, N.

AU - Roe, B. A.

AU - Chissoe, S.

AU - Dunham, I.

AU - Hunt, A. R.

AU - Collins, J. E.

AU - Bruskiewich, R.

AU - Beare, D. M.

AU - Clamp, M.

AU - Smink, L. J.

AU - Ainscough, R.

AU - Almeida, J. P.

AU - Babbage, A.

AU - Bagguley, C.

AU - Bailey, J.

AU - Barlow, K.

AU - Bates, K. N.

AU - Beasley, O.

AU - Bird, C. P.

AU - Blakey, S.

AU - Bridgeman, A. M.

AU - Buck, D.

AU - Burgess, J.

AU - Burrill, W. D.

AU - Burton, J.

AU - Carder, C.

AU - Carter, N. P.

AU - Chen, Y.

AU - Clark, G.

AU - Clegg, S. M.

AU - Cobley, V.

AU - Cole, C. G.

AU - Collier, R. E.

AU - Connor, R. E.

AU - Conroy, D.

AU - Corby, N.

AU - Coville, G. J.

AU - Cox, A. V.

AU - Davis, J.

AU - Dawson, E.

AU - Dhami, P. D.

AU - Dockree, C.

AU - Dodsworth, S. J.

AU - Durbin, R. M.

AU - Ellington, A.

AU - Evans, K. L.

AU - Fey, J. M.

AU - Fleming, K.

AU - French, L.

AU - Garner, A. A.

AU - Gilbert, J. G R

AU - Goward, M. E.

AU - Grafham, D.

AU - Griffiths, M. N.

AU - Hall, C.

AU - Hall, R.

AU - Hall-Tamlyn, G.

AU - Heathcott, R. W.

AU - Ho, S.

AU - Holmes, S.

AU - Hunt, S. E.

AU - Jones, M. C.

AU - Kershaw, J.

AU - Kimberley, A.

AU - King, A.

AU - Laird, G. K.

AU - Langford, C. F.

AU - Leversha, M. A.

AU - Lloyd, C.

AU - Lloyd, D. M.

AU - Martyn, I. D.

AU - Mashreghi-Mohammadi, M.

AU - Matthews, L.

AU - Mccann, O. T.

AU - Mcclay, J.

AU - Mclaren, S.

AU - Mcmurray, A. A.

AU - Milne, S. A.

AU - Mortimore, B. J.

AU - Odell, C. N.

AU - Pavitt, R.

AU - Pearce, A. V.

AU - Pearson, D.

AU - Phillimore, B. J.

AU - Phillips, S. H.

AU - Plumb, R. W.

AU - Ramsay, H.

AU - Ramsey, Y.

AU - Rogers, L.

AU - Ross, M. T.

AU - Scott, C. E.

AU - Sehra, H. K.

AU - Skuce, C. D.

AU - Smalley, S.

AU - Smith, M. L.

AU - Soderlund, C.

AU - Spragon, L.

AU - Steward, C. A.

AU - Sulston, J. E.

AU - Swann, R. M.

AU - Vaudin, M.

AU - Wall, M.

AU - Wallis, J. M.

AU - Whiteley, M. N.

AU - Willey, D.

AU - Williams, L.

AU - Williams, S.

AU - Williamson, H.

AU - Wilmer, T. E.

AU - Wilming, L.

AU - Wright, C. L.

AU - Hubbard, T.

AU - Bentley, D. R.

AU - Beck, S.

AU - Rogers, J.

AU - Shimizu, N.

AU - Minoshima, S.

AU - Kawasaki, K.

AU - Sasaki, Takashi

AU - Asakawa, S.

AU - Kudo, Jun

AU - Shintani, A.

AU - Shibuya, Kazunori

AU - Yoshizaki, Y.

AU - Aoki, N.

AU - Mitsuyama, S.

AU - Roe, B. A.

AU - Chen, F.

AU - Chu, L.

AU - Crabtree, J.

AU - Deschamps, S.

AU - Do, A.

AU - Do, T.

AU - Dorman, A.

AU - Fang, F.

AU - Fu, Y.

AU - Hu, P.

AU - Hua, A.

AU - Kenton, S.

AU - Lai, H.

AU - Lao, H. I.

AU - Lewis, J.

AU - Lewis, S.

AU - Lin, S. P.

AU - Loh, P.

AU - Malaj, E.

AU - Nguyen, T.

AU - Pan, H.

AU - Phan, S.

AU - Qi, S.

AU - Qian, Y.

AU - Ray, L.

AU - Ren, Q.

AU - Shaull, S.

AU - Sloan, D.

AU - Song, L.

AU - Wang, Q.

AU - Wang, Y.

AU - Wang, Z.

AU - White, J.

AU - Willingham, D.

AU - Wu, H.

AU - Yao, Z.

AU - Zhan, M.

AU - Zhang, G.

AU - Chissoe, S.

AU - Murray, J.

AU - Miller, N.

AU - Minx, P.

AU - Fulton, R.

AU - Johnson, D.

AU - Bemis, G.

AU - Bentley, D.

AU - Bradshaw, H.

AU - Bourne, S.

AU - Cordes, M.

AU - Du, Z.

AU - Fulton, L.

AU - Goela, D.

AU - Graves, T.

AU - Hawkins, J.

AU - Hinds, K.

AU - Kemp, K.

AU - Latreille, P.

AU - Layman, D.

AU - Ozersky, P.

AU - Rohlfing, T.

AU - Scheet, P.

AU - Walker, C.

AU - Wamsley, A.

AU - Wohldmann, P.

AU - Pepin, K.

AU - Nelson, J.

AU - Korf, I.

AU - Bedell, J. A.

AU - Hillier, L.

AU - Mardis, E.

AU - Waterston, R.

AU - Wilson, R.

AU - Emanuel, B. S.

AU - Shaikh, T.

AU - Kurahashi, H.

AU - Saitta, S.

AU - Budarf, M. L.

AU - Mcdermid, H. E.

AU - Johnson, A.

AU - Wong, A. C C

AU - Morrow, B. E.

AU - Edelmann, L.

AU - Kim, U. J.

AU - Shizuya, H.

AU - Simon, M. I.

AU - Dumanski, J. P.

AU - Peyrard, M.

AU - Kedra, D.

AU - Seroussi, E.

AU - Fransson, I.

AU - Tapia, I.

AU - Bruder, C. E.

AU - O'Brien, K. P.

PY - 1999/12/2

Y1 - 1999/12/2

N2 - Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. Furthermore, the sequence is a rich and permanent source of information for the design of further biological studies of the organism and for the study of evolution through cross-species sequence comparison. The power of this approach has been amply demonstrated by the determination of the sequences of a number of microbial and model organisms. The next step is to obtain the complete sequence of the entire human genome. Here we report the sequence of the euchromatic part of human chromosome 22. The sequence obtained consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome.

AB - Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. Furthermore, the sequence is a rich and permanent source of information for the design of further biological studies of the organism and for the study of evolution through cross-species sequence comparison. The power of this approach has been amply demonstrated by the determination of the sequences of a number of microbial and model organisms. The next step is to obtain the complete sequence of the entire human genome. Here we report the sequence of the euchromatic part of human chromosome 22. The sequence obtained consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome.

UR - http://www.scopus.com/inward/record.url?scp=79960655760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960655760&partnerID=8YFLogxK

U2 - 10.1038/990031

DO - 10.1038/990031

M3 - Article

C2 - 10591208

AN - SCOPUS:79960655760

VL - 402

SP - 489

EP - 495

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 6761

ER -