The drug burden of anticholinergics and sedatives and influence on outcomes in the community-living oldest old: The Tokyo oldest old survey on total health (TOOTH) survey

Research output: Contribution to journalArticle

Abstract

Aim: The objective of this study was to assess the burdens of anticholinergic and sedative drugs in community-living individuals of 85 years of age or older. Methods: The Tokyo Oldest Old survey on Total Health (TOOTH) is a cohort study designed to assess the physical, mental, and oral health of the community-living oldest old. We investigated the relationships between the anticholinergic/sedative burden and physical/cognitive outcomes. The drug burden was assessed by the Drug Burden Index (DBI). Relationships between the DBI score and the physical/cognitive outcomes were evaluated by multivariate regression. The age-related changes (baseline to 3-year follow-up) of these outcomes were also investigated. Results: At baseline, the data of 306 subjects were subjected to a cross-sectional analysis. The Instrumental Activities of Daily Living and Mini Mental State Examination scores were found to be significantly associated with the DBI score. After 3 years, the Activities of Daily Living score was significantly associated with the DBI score in 176 subjects. Changes in these outcome measures were small during the 3-year follow-up period and were not associated with the DBI scores at baseline. Discussion: DBI in the community-living oldest old were evaluated. Our findings suggest that anticholinergic and sedative drugs may influence the physical and cognitive function in the oldest old. Additional studies should be performed to investigate the relationships between the change of the physical/cognitive functions and the DBI score over a long-term observation period.

Original languageEnglish
Pages (from-to)403-416
Number of pages14
JournalJapanese Journal of Geriatrics
Volume54
Issue number3
DOIs
Publication statusPublished - 2017

Fingerprint

Tokyo
Cholinergic Antagonists
Health Surveys
Hypnotics and Sedatives
Pharmaceutical Preparations
Activities of Daily Living
Cognition
Surveys and Questionnaires
Oral Health
Mental Health
Cohort Studies
Cross-Sectional Studies
Observation
Outcome Assessment (Health Care)

Keywords

  • Anticholinergics
  • Drug Burden Index
  • Oldest old
  • Sedatives

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

@article{7ca4cebf62944502b6046ccd738922f6,
title = "The drug burden of anticholinergics and sedatives and influence on outcomes in the community-living oldest old: The Tokyo oldest old survey on total health (TOOTH) survey",
abstract = "Aim: The objective of this study was to assess the burdens of anticholinergic and sedative drugs in community-living individuals of 85 years of age or older. Methods: The Tokyo Oldest Old survey on Total Health (TOOTH) is a cohort study designed to assess the physical, mental, and oral health of the community-living oldest old. We investigated the relationships between the anticholinergic/sedative burden and physical/cognitive outcomes. The drug burden was assessed by the Drug Burden Index (DBI). Relationships between the DBI score and the physical/cognitive outcomes were evaluated by multivariate regression. The age-related changes (baseline to 3-year follow-up) of these outcomes were also investigated. Results: At baseline, the data of 306 subjects were subjected to a cross-sectional analysis. The Instrumental Activities of Daily Living and Mini Mental State Examination scores were found to be significantly associated with the DBI score. After 3 years, the Activities of Daily Living score was significantly associated with the DBI score in 176 subjects. Changes in these outcome measures were small during the 3-year follow-up period and were not associated with the DBI scores at baseline. Discussion: DBI in the community-living oldest old were evaluated. Our findings suggest that anticholinergic and sedative drugs may influence the physical and cognitive function in the oldest old. Additional studies should be performed to investigate the relationships between the change of the physical/cognitive functions and the DBI score over a long-term observation period.",
keywords = "Anticholinergics, Drug Burden Index, Oldest old, Sedatives",
author = "Ryohei Sato and Yasumichi Arai and Yukiko Abe and Michiyo Takayama and Hisashi Urushihara",
year = "2017",
doi = "10.3143/geriatrics.54.403",
language = "English",
volume = "54",
pages = "403--416",
journal = "Japanese Journal of Geriatrics",
issn = "0300-9173",
publisher = "Japan Geriatrics Society",
number = "3",

}

TY - JOUR

T1 - The drug burden of anticholinergics and sedatives and influence on outcomes in the community-living oldest old

T2 - The Tokyo oldest old survey on total health (TOOTH) survey

AU - Sato, Ryohei

AU - Arai, Yasumichi

AU - Abe, Yukiko

AU - Takayama, Michiyo

AU - Urushihara, Hisashi

PY - 2017

Y1 - 2017

N2 - Aim: The objective of this study was to assess the burdens of anticholinergic and sedative drugs in community-living individuals of 85 years of age or older. Methods: The Tokyo Oldest Old survey on Total Health (TOOTH) is a cohort study designed to assess the physical, mental, and oral health of the community-living oldest old. We investigated the relationships between the anticholinergic/sedative burden and physical/cognitive outcomes. The drug burden was assessed by the Drug Burden Index (DBI). Relationships between the DBI score and the physical/cognitive outcomes were evaluated by multivariate regression. The age-related changes (baseline to 3-year follow-up) of these outcomes were also investigated. Results: At baseline, the data of 306 subjects were subjected to a cross-sectional analysis. The Instrumental Activities of Daily Living and Mini Mental State Examination scores were found to be significantly associated with the DBI score. After 3 years, the Activities of Daily Living score was significantly associated with the DBI score in 176 subjects. Changes in these outcome measures were small during the 3-year follow-up period and were not associated with the DBI scores at baseline. Discussion: DBI in the community-living oldest old were evaluated. Our findings suggest that anticholinergic and sedative drugs may influence the physical and cognitive function in the oldest old. Additional studies should be performed to investigate the relationships between the change of the physical/cognitive functions and the DBI score over a long-term observation period.

AB - Aim: The objective of this study was to assess the burdens of anticholinergic and sedative drugs in community-living individuals of 85 years of age or older. Methods: The Tokyo Oldest Old survey on Total Health (TOOTH) is a cohort study designed to assess the physical, mental, and oral health of the community-living oldest old. We investigated the relationships between the anticholinergic/sedative burden and physical/cognitive outcomes. The drug burden was assessed by the Drug Burden Index (DBI). Relationships between the DBI score and the physical/cognitive outcomes were evaluated by multivariate regression. The age-related changes (baseline to 3-year follow-up) of these outcomes were also investigated. Results: At baseline, the data of 306 subjects were subjected to a cross-sectional analysis. The Instrumental Activities of Daily Living and Mini Mental State Examination scores were found to be significantly associated with the DBI score. After 3 years, the Activities of Daily Living score was significantly associated with the DBI score in 176 subjects. Changes in these outcome measures were small during the 3-year follow-up period and were not associated with the DBI scores at baseline. Discussion: DBI in the community-living oldest old were evaluated. Our findings suggest that anticholinergic and sedative drugs may influence the physical and cognitive function in the oldest old. Additional studies should be performed to investigate the relationships between the change of the physical/cognitive functions and the DBI score over a long-term observation period.

KW - Anticholinergics

KW - Drug Burden Index

KW - Oldest old

KW - Sedatives

UR - http://www.scopus.com/inward/record.url?scp=85028601868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028601868&partnerID=8YFLogxK

U2 - 10.3143/geriatrics.54.403

DO - 10.3143/geriatrics.54.403

M3 - Article

C2 - 28855465

AN - SCOPUS:85028601868

VL - 54

SP - 403

EP - 416

JO - Japanese Journal of Geriatrics

JF - Japanese Journal of Geriatrics

SN - 0300-9173

IS - 3

ER -