TY - JOUR
T1 - The effect of calcitonin gene-related peptide on pancreatic blood flow and secretion in conscious dogs
AU - Jin, Chunxiang
AU - Naruse, Satoru
AU - Kitagawa, Motoji
AU - Ishiguro, Hiroshi
AU - Nakajima, Morio
AU - Mizuno, Nobumasa
AU - Ko, Shigeru B.H.
AU - Hayakawa, Tetsuo
N1 - Funding Information:
This work was supported by grants from the Pancreas Research Foundation of Japan and Ministry of Education, Science, and Culture, Japan. We thank Dr. V. Wray for his suggestions. Chunxiang Jin is a visiting scientist from Norman Bethune University of Medical Science, Changchun, China, on a Sasagawa Medical Fellowship.
PY - 2001/5/5
Y1 - 2001/5/5
N2 - The effects of human α-calcitonin gene-related peptide (α-CGRP) and β-CGRP on pancreatic arterial (PA), superior mesenteric (SMA) and left gastric arterial (LGA) blood flows were studied by ultrasound transit-time blood flow meters in five conscious dogs. Intravenous injections of α-CGRP and β-CGRP (5-200 pmol/kg) induced a dose-related increase in PA flow and a dose-related decrease in its resistance. At lower doses, α-CGRP was more potent than β-CGRP, but their maximal responses were similar. The blood flow responses to α-CGRP (200 pmol/kg) were 153% of the basal flow in LGA, 313% in PA, and 534% in SMA, while those to VIP (100 pmol/kg) were 467% in LGA, 953% in PA and 163% in SMA. Somatostatin reduced blood flow in all arteries. α-CGRP, but not β-CGRP, at higher doses induced gastric contractions and pancreatic protein-rich secretion, which were blocked by atropine. These results suggest that CGRP in perivascular nerves in the pancreas may regulate pancreatic blood flow in dogs but its physiological function remains to be studied.
AB - The effects of human α-calcitonin gene-related peptide (α-CGRP) and β-CGRP on pancreatic arterial (PA), superior mesenteric (SMA) and left gastric arterial (LGA) blood flows were studied by ultrasound transit-time blood flow meters in five conscious dogs. Intravenous injections of α-CGRP and β-CGRP (5-200 pmol/kg) induced a dose-related increase in PA flow and a dose-related decrease in its resistance. At lower doses, α-CGRP was more potent than β-CGRP, but their maximal responses were similar. The blood flow responses to α-CGRP (200 pmol/kg) were 153% of the basal flow in LGA, 313% in PA, and 534% in SMA, while those to VIP (100 pmol/kg) were 467% in LGA, 953% in PA and 163% in SMA. Somatostatin reduced blood flow in all arteries. α-CGRP, but not β-CGRP, at higher doses induced gastric contractions and pancreatic protein-rich secretion, which were blocked by atropine. These results suggest that CGRP in perivascular nerves in the pancreas may regulate pancreatic blood flow in dogs but its physiological function remains to be studied.
KW - CGRP
KW - Gastric blood flow
KW - Intestinal blood flow
KW - Pancreatic blood flow
KW - Somatostatin
KW - Vasoactive intestinal polypeptide
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U2 - 10.1016/S0167-0115(01)00214-2
DO - 10.1016/S0167-0115(01)00214-2
M3 - Article
C2 - 11257309
AN - SCOPUS:0035810772
SN - 0167-0115
VL - 99
SP - 9
EP - 15
JO - Regulatory Peptides
JF - Regulatory Peptides
IS - 1
ER -