The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss: a nationwide survey in Japan

Masahiro Okada; Naohito Hato; Shin Ya Nishio; Ryosuke Kitoh; Kaoru Ogawa; Sho Kanzaki; Michihiko Sone; Satoshi Fukuda; Akira Hara; Tetsuo Ikezono; Kotaro Ishikawa; Satoshi Iwasaki; Kimitaka Kaga; Seiji Kakehata; Atsushi Matsubara; Tatsuo Matsunaga; Takaaki Murata; Yasushi Naito; Takashi Nakagawa; Kazunori Nishizaki; Yoshihiro Noguchi; Hajime Sano; Hiroaki Sato; Mikio Suzuki; Hideo Shojaku; Haruo Takahashi; Hidehiko Takeda; Tetsuya Tono; Hiroshi Yamashita; Tatsuya Yamasoba; Shin Ichi Usami

doi:10.1080/00016489.2017.1296970

The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss: a nationwide survey in Japan

Masahiro Okada, Naohito Hato, Shin Ya Nishio, Ryosuke Kitoh, Kaoru Ogawa, Sho Kanzaki, Michihiko Sone, Satoshi Fukuda, Akira Hara, Tetsuo Ikezono, Kotaro Ishikawa, Satoshi Iwasaki, Kimitaka Kaga, Seiji Kakehata, Atsushi Matsubara, Tatsuo Matsunaga, Takaaki Murata, Yasushi Naito, Takashi Nakagawa, Kazunori NishizakiYoshihiro Noguchi, Hajime Sano, Hiroaki Sato, Mikio Suzuki, Hideo Shojaku, Haruo Takahashi, Hidehiko Takeda, Tetsuya Tono, Hiroshi Yamashita, Tatsuya Yamasoba, Shin Ichi Usami

Department of Otorhinolaryngology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Objective: To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. Methods: Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese multicenter database between April 2014 and March 2016. Subjects were divided into four groups according to initial therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic steroids (ITS), and (4) no steroids. Hearing outcomes were compared among the groups. Results: In total, 1305 patients were enrolled. The final hearing level and hearing gain of patients treated with steroids + PGs were significantly higher than those of patients treated with steroids alone or no steroids. The ratio of good prognosis (complete recovery or marked improvement) in patients treated with steroids + PGs was higher than that in patients treated with steroids alone or no steroids. There was no difference in the prognosis of patients treated with steroids alone or no steroids. Conclusion: A large number of patients with idiopathic SSNHL were registered in a multicenter database. PG use in combination with steroid administration was associated with a good hearing prognosis in patients with severe hearing loss.

Original language	English
Pages (from-to)	S30-S33
Journal	Acta Oto-Laryngologica
Volume	137
DOIs	https://doi.org/10.1080/00016489.2017.1296970
Publication status	Published - 2017 Mar 10

Keywords

Idiopathic sudden sensorineural hearing
intratympanic steroid injection
prostaglandin
steroid

ASJC Scopus subject areas

Otorhinolaryngology

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Okada, M., Hato, N., Nishio, S. Y., Kitoh, R., Ogawa, K., Kanzaki, S., Sone, M., Fukuda, S., Hara, A., Ikezono, T., Ishikawa, K., Iwasaki, S., Kaga, K., Kakehata, S., Matsubara, A., Matsunaga, T., Murata, T., Naito, Y., Nakagawa, T., ... Usami, S. I. (2017). The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss: a nationwide survey in Japan. Acta Oto-Laryngologica, 137, S30-S33. https://doi.org/10.1080/00016489.2017.1296970

The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss : a nationwide survey in Japan. / Okada, Masahiro; Hato, Naohito; Nishio, Shin Ya; Kitoh, Ryosuke; Ogawa, Kaoru ; Kanzaki, Sho; Sone, Michihiko; Fukuda, Satoshi; Hara, Akira; Ikezono, Tetsuo; Ishikawa, Kotaro; Iwasaki, Satoshi; Kaga, Kimitaka; Kakehata, Seiji; Matsubara, Atsushi; Matsunaga, Tatsuo; Murata, Takaaki; Naito, Yasushi; Nakagawa, Takashi; Nishizaki, Kazunori; Noguchi, Yoshihiro; Sano, Hajime; Sato, Hiroaki; Suzuki, Mikio; Shojaku, Hideo; Takahashi, Haruo; Takeda, Hidehiko; Tono, Tetsuya; Yamashita, Hiroshi; Yamasoba, Tatsuya; Usami, Shin Ichi.

In: Acta Oto-Laryngologica, Vol. 137, 10.03.2017, p. S30-S33.

Research output: Contribution to journal › Article › peer-review

Okada, M, Hato, N, Nishio, SY, Kitoh, R, Ogawa, K , Kanzaki, S, Sone, M, Fukuda, S, Hara, A, Ikezono, T, Ishikawa, K, Iwasaki, S, Kaga, K, Kakehata, S, Matsubara, A, Matsunaga, T, Murata, T, Naito, Y, Nakagawa, T, Nishizaki, K, Noguchi, Y, Sano, H, Sato, H, Suzuki, M, Shojaku, H, Takahashi, H, Takeda, H, Tono, T, Yamashita, H, Yamasoba, T & Usami, SI 2017, 'The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss: a nationwide survey in Japan', Acta Oto-Laryngologica, vol. 137, pp. S30-S33. https://doi.org/10.1080/00016489.2017.1296970

Okada, Masahiro ; Hato, Naohito ; Nishio, Shin Ya ; Kitoh, Ryosuke ; Ogawa, Kaoru ; Kanzaki, Sho ; Sone, Michihiko ; Fukuda, Satoshi ; Hara, Akira ; Ikezono, Tetsuo ; Ishikawa, Kotaro ; Iwasaki, Satoshi ; Kaga, Kimitaka ; Kakehata, Seiji ; Matsubara, Atsushi ; Matsunaga, Tatsuo ; Murata, Takaaki ; Naito, Yasushi ; Nakagawa, Takashi ; Nishizaki, Kazunori ; Noguchi, Yoshihiro ; Sano, Hajime ; Sato, Hiroaki ; Suzuki, Mikio ; Shojaku, Hideo ; Takahashi, Haruo ; Takeda, Hidehiko ; Tono, Tetsuya ; Yamashita, Hiroshi ; Yamasoba, Tatsuya ; Usami, Shin Ichi. / The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss : a nationwide survey in Japan. In: Acta Oto-Laryngologica. 2017 ; Vol. 137. pp. S30-S33.

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title = "The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss: a nationwide survey in Japan",

abstract = "Objective: To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. Methods: Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese multicenter database between April 2014 and March 2016. Subjects were divided into four groups according to initial therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic steroids (ITS), and (4) no steroids. Hearing outcomes were compared among the groups. Results: In total, 1305 patients were enrolled. The final hearing level and hearing gain of patients treated with steroids + PGs were significantly higher than those of patients treated with steroids alone or no steroids. The ratio of good prognosis (complete recovery or marked improvement) in patients treated with steroids + PGs was higher than that in patients treated with steroids alone or no steroids. There was no difference in the prognosis of patients treated with steroids alone or no steroids. Conclusion: A large number of patients with idiopathic SSNHL were registered in a multicenter database. PG use in combination with steroid administration was associated with a good hearing prognosis in patients with severe hearing loss.",

keywords = "Idiopathic sudden sensorineural hearing, intratympanic steroid injection, prostaglandin, steroid",

author = "Masahiro Okada and Naohito Hato and Nishio, {Shin Ya} and Ryosuke Kitoh and Kaoru Ogawa and Sho Kanzaki and Michihiko Sone and Satoshi Fukuda and Akira Hara and Tetsuo Ikezono and Kotaro Ishikawa and Satoshi Iwasaki and Kimitaka Kaga and Seiji Kakehata and Atsushi Matsubara and Tatsuo Matsunaga and Takaaki Murata and Yasushi Naito and Takashi Nakagawa and Kazunori Nishizaki and Yoshihiro Noguchi and Hajime Sano and Hiroaki Sato and Mikio Suzuki and Hideo Shojaku and Haruo Takahashi and Hidehiko Takeda and Tetsuya Tono and Hiroshi Yamashita and Tatsuya Yamasoba and Usami, {Shin Ichi}",

note = "Funding Information: This study was supported by a Health and Labour Sciences Research Grant for Comprehensive Research on Disability Health and Welfare from the Ministry of Health, Labour and Welfare, Japan (http://www.mhlw.go.jp/english/) (S.U.).",

year = "2017",

month = mar,

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doi = "10.1080/00016489.2017.1296970",

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T1 - The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss

T2 - a nationwide survey in Japan

AU - Okada, Masahiro

AU - Hato, Naohito

AU - Nishio, Shin Ya

AU - Kitoh, Ryosuke

AU - Ogawa, Kaoru

AU - Kanzaki, Sho

AU - Sone, Michihiko

AU - Fukuda, Satoshi

AU - Hara, Akira

AU - Ikezono, Tetsuo

AU - Ishikawa, Kotaro

AU - Iwasaki, Satoshi

AU - Kaga, Kimitaka

AU - Kakehata, Seiji

AU - Matsubara, Atsushi

AU - Matsunaga, Tatsuo

AU - Murata, Takaaki

AU - Naito, Yasushi

AU - Nakagawa, Takashi

AU - Nishizaki, Kazunori

AU - Noguchi, Yoshihiro

AU - Sano, Hajime

AU - Sato, Hiroaki

AU - Suzuki, Mikio

AU - Shojaku, Hideo

AU - Takahashi, Haruo

AU - Takeda, Hidehiko

AU - Tono, Tetsuya

AU - Yamashita, Hiroshi

AU - Yamasoba, Tatsuya

AU - Usami, Shin Ichi

N1 - Funding Information: This study was supported by a Health and Labour Sciences Research Grant for Comprehensive Research on Disability Health and Welfare from the Ministry of Health, Labour and Welfare, Japan (http://www.mhlw.go.jp/english/) (S.U.).

PY - 2017/3/10

Y1 - 2017/3/10

N2 - Objective: To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. Methods: Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese multicenter database between April 2014 and March 2016. Subjects were divided into four groups according to initial therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic steroids (ITS), and (4) no steroids. Hearing outcomes were compared among the groups. Results: In total, 1305 patients were enrolled. The final hearing level and hearing gain of patients treated with steroids + PGs were significantly higher than those of patients treated with steroids alone or no steroids. The ratio of good prognosis (complete recovery or marked improvement) in patients treated with steroids + PGs was higher than that in patients treated with steroids alone or no steroids. There was no difference in the prognosis of patients treated with steroids alone or no steroids. Conclusion: A large number of patients with idiopathic SSNHL were registered in a multicenter database. PG use in combination with steroid administration was associated with a good hearing prognosis in patients with severe hearing loss.

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