TY - JOUR
T1 - The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss
T2 - a nationwide survey in Japan
AU - Okada, Masahiro
AU - Hato, Naohito
AU - Nishio, Shin Ya
AU - Kitoh, Ryosuke
AU - Ogawa, Kaoru
AU - Kanzaki, Sho
AU - Sone, Michihiko
AU - Fukuda, Satoshi
AU - Hara, Akira
AU - Ikezono, Tetsuo
AU - Ishikawa, Kotaro
AU - Iwasaki, Satoshi
AU - Kaga, Kimitaka
AU - Kakehata, Seiji
AU - Matsubara, Atsushi
AU - Matsunaga, Tatsuo
AU - Murata, Takaaki
AU - Naito, Yasushi
AU - Nakagawa, Takashi
AU - Nishizaki, Kazunori
AU - Noguchi, Yoshihiro
AU - Sano, Hajime
AU - Sato, Hiroaki
AU - Suzuki, Mikio
AU - Shojaku, Hideo
AU - Takahashi, Haruo
AU - Takeda, Hidehiko
AU - Tono, Tetsuya
AU - Yamashita, Hiroshi
AU - Yamasoba, Tatsuya
AU - Usami, Shin Ichi
PY - 2017/3/10
Y1 - 2017/3/10
N2 - Objective: To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. Methods: Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese multicenter database between April 2014 and March 2016. Subjects were divided into four groups according to initial therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic steroids (ITS), and (4) no steroids. Hearing outcomes were compared among the groups. Results: In total, 1305 patients were enrolled. The final hearing level and hearing gain of patients treated with steroids + PGs were significantly higher than those of patients treated with steroids alone or no steroids. The ratio of good prognosis (complete recovery or marked improvement) in patients treated with steroids + PGs was higher than that in patients treated with steroids alone or no steroids. There was no difference in the prognosis of patients treated with steroids alone or no steroids. Conclusion: A large number of patients with idiopathic SSNHL were registered in a multicenter database. PG use in combination with steroid administration was associated with a good hearing prognosis in patients with severe hearing loss.
AB - Objective: To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. Methods: Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese multicenter database between April 2014 and March 2016. Subjects were divided into four groups according to initial therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic steroids (ITS), and (4) no steroids. Hearing outcomes were compared among the groups. Results: In total, 1305 patients were enrolled. The final hearing level and hearing gain of patients treated with steroids + PGs were significantly higher than those of patients treated with steroids alone or no steroids. The ratio of good prognosis (complete recovery or marked improvement) in patients treated with steroids + PGs was higher than that in patients treated with steroids alone or no steroids. There was no difference in the prognosis of patients treated with steroids alone or no steroids. Conclusion: A large number of patients with idiopathic SSNHL were registered in a multicenter database. PG use in combination with steroid administration was associated with a good hearing prognosis in patients with severe hearing loss.
KW - Idiopathic sudden sensorineural hearing
KW - intratympanic steroid injection
KW - prostaglandin
KW - steroid
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U2 - 10.1080/00016489.2017.1296970
DO - 10.1080/00016489.2017.1296970
M3 - Article
C2 - 28359220
AN - SCOPUS:85016483619
VL - 137
SP - S30-S33
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
SN - 0001-6489
ER -