The effect of OK-432 on modifying a spontaneous lung metastasis from murine fibrosarcomas

H. Ito, S. Yamada, I. Nishiguchi, N. Shigematsu, T. Nakayama, T. Kuribayashi, S. Hashimoto

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Abstract

The authors have investigated the effect of OK-432 on the spontaneous metastasis from a murine fibrosarcoma, either an NFSA or a SANH, that had been transplanted into the right thigh of C3H mice. When the NFSA or the SANH tumors grew to 7 mm in diameter, they were irradiated with a single dose of 30 Gy and 20 Gy, respectively. A local administration of OK-432 (2.5 KE) around each of the tumors was initiated immediately after irradiation and continued twice a week. It was found that regrowth in both tumors was not modified by the OK-432, though the mean number of metastatic lung nodules per mouse from either tumor was significantly decreased. The incidence of a lung metastasis also was reduced by the OK-432 but not significantly. Further, mice that had received a SANH tumor transplant developed a lymph node metastasis in the abdominal cavity that was depressed by the OK-432.

Original languageEnglish
Pages (from-to)993-997
Number of pages5
JournalGan no rinsho. Japan journal of cancer clinics
Volume36
Issue number9
Publication statusPublished - 1990 Aug 1

ASJC Scopus subject areas

  • Medicine(all)

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    Ito, H., Yamada, S., Nishiguchi, I., Shigematsu, N., Nakayama, T., Kuribayashi, T., & Hashimoto, S. (1990). The effect of OK-432 on modifying a spontaneous lung metastasis from murine fibrosarcomas. Gan no rinsho. Japan journal of cancer clinics, 36(9), 993-997.